TY - JOUR
T1 - Association and diagnostic value of a novel uric acid index to cardiovascular risk
AU - Rojas-Humpire, Ricardo
AU - Jáuregui-Rodríguez, Keila
AU - Albornoz, Silvana
AU - Ruiz Mamani, Percy G.
AU - Gutierrez-Ajalcriña, Rosmery
AU - Huancahuire-Vega, Salomón
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2021/8
Y1 - 2021/8
N2 - Objectives: Cardiovascular diseases (CVD) are the leading cause of death and disability worldwide. The aim of this study was to assess the association and diagnostic value of a novel uric acid index (UA index) to cardiovascular risk (CVR). Design: and Methods: An analytical cross-sectional study was performed. We analyzed data from the Plan for Prevention and Surveillance of Communicable and Non-Communicable Diseases at the Hospital de Huaycan, Peru. The QRISK model was used to measure the CVR. Stepwise regression models were performed to determine significant factors to predict CVR and formulate the UA index, then the association of UA index and high CVR was evaluated by Poisson regression models, and the diagnostic accuracy was verified through ROC curves. Results: In total 291 participants (206 women and 85 men) were analyzed. The correlation between UA index to CVR was stronger (R2:0.31, p < 0.001) than uric acid (UA) alone (R2:0.19, p < 0.001), and the contribution of UA was stronger than triglycerides or glucose in the stepwise regression model. In the Poisson models, the UA index adjusted model (PRa: 1.58, CI95% 1.11–2.24) presented significant independent association to CVR. The diagnostic accuracy was similar in men (cut-off: 10.8, AUC:0.81; 0.75–0.87) and women (cut-off: 10.0; AUC: 0.77, 0.71–0.84). Conclusion: UA index presented a good diagnostic accuracy and independent significant association to high CVR in adults from Peru. This marker can be used to assess CVR and follow therapeutic progress in primary health care.
AB - Objectives: Cardiovascular diseases (CVD) are the leading cause of death and disability worldwide. The aim of this study was to assess the association and diagnostic value of a novel uric acid index (UA index) to cardiovascular risk (CVR). Design: and Methods: An analytical cross-sectional study was performed. We analyzed data from the Plan for Prevention and Surveillance of Communicable and Non-Communicable Diseases at the Hospital de Huaycan, Peru. The QRISK model was used to measure the CVR. Stepwise regression models were performed to determine significant factors to predict CVR and formulate the UA index, then the association of UA index and high CVR was evaluated by Poisson regression models, and the diagnostic accuracy was verified through ROC curves. Results: In total 291 participants (206 women and 85 men) were analyzed. The correlation between UA index to CVR was stronger (R2:0.31, p < 0.001) than uric acid (UA) alone (R2:0.19, p < 0.001), and the contribution of UA was stronger than triglycerides or glucose in the stepwise regression model. In the Poisson models, the UA index adjusted model (PRa: 1.58, CI95% 1.11–2.24) presented significant independent association to CVR. The diagnostic accuracy was similar in men (cut-off: 10.8, AUC:0.81; 0.75–0.87) and women (cut-off: 10.0; AUC: 0.77, 0.71–0.84). Conclusion: UA index presented a good diagnostic accuracy and independent significant association to high CVR in adults from Peru. This marker can be used to assess CVR and follow therapeutic progress in primary health care.
KW - Biomarker
KW - Cardiometabolic risk factors
KW - Cardiovascular disease
KW - Primary health care
KW - Uric acid
UR - http://www.scopus.com/inward/record.url?scp=85110532091&partnerID=8YFLogxK
U2 - 10.1016/j.plabm.2021.e00247
DO - 10.1016/j.plabm.2021.e00247
M3 - Article
AN - SCOPUS:85110532091
SN - 2352-5517
VL - 26
JO - Practical Laboratory Medicine
JF - Practical Laboratory Medicine
M1 - e00247
ER -