Functional analysis using whole-genome sequencing of a drug-sensitive Mycobacterium tuberculosis strain from Peru

D. Tarazona; V. Borda; M. Galarza; J. C. Agapito; H. Guio

doi:10.1128/genomeA.e00087-14

Functional analysis using whole-genome sequencing of a drug-sensitive Mycobacterium tuberculosis strain from Peru

D. Tarazona, V. Borda, M. Galarza, J. C. Agapito, H. Guio

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2 Scopus citations

Abstract

We report the whole-genome sequence of a Latin American-Mediterranean (LAM) lineage drug-sensitive Mycobacterium tuberculosis strain from Peru, INS-SEN. The functional analysis revealed more mutations in secondary metabolite biosynthesis, transport, and catabolism (clusters of orthologous groups [COG] category Q) than for other LAM-sensitive strains. This study contributes to the understanding of the genomic diversity of drug-sensitive M. tuberculosis.

Original language	English
Article number	e00087-14
Journal	Genome Announcements
Volume	2
Issue number	1
DOIs	https://doi.org/10.1128/genomeA.e00087-14
State	Published - 2014
Externally published	Yes

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abstract = "We report the whole-genome sequence of a Latin American-Mediterranean (LAM) lineage drug-sensitive Mycobacterium tuberculosis strain from Peru, INS-SEN. The functional analysis revealed more mutations in secondary metabolite biosynthesis, transport, and catabolism (clusters of orthologous groups [COG] category Q) than for other LAM-sensitive strains. This study contributes to the understanding of the genomic diversity of drug-sensitive M. tuberculosis.",

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AU - Agapito, J. C.

AU - Guio, H.

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AB - We report the whole-genome sequence of a Latin American-Mediterranean (LAM) lineage drug-sensitive Mycobacterium tuberculosis strain from Peru, INS-SEN. The functional analysis revealed more mutations in secondary metabolite biosynthesis, transport, and catabolism (clusters of orthologous groups [COG] category Q) than for other LAM-sensitive strains. This study contributes to the understanding of the genomic diversity of drug-sensitive M. tuberculosis.

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Functional analysis using whole-genome sequencing of a drug-sensitive Mycobacterium tuberculosis strain from Peru

Abstract

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