GENES RESISTENTES A CARBAPENÉMICOS Y COLISTINA AISLADOS EN Musca domestica PROVENIENTE DE UN BASUR AL CERCANO A UN HOSPITAL DE LIMA

Miguel A. Alarcón-Calle, Víctor L. Osorio-Guevara, Ramsés Salas-Asencios, José Yareta, Pool Marcos-Carbajal, María E. Rodrigo-Rojas

Research output: Contribution to journalArticlepeer-review

Abstract

The objective was to determine the presence of carbapenem resistance genes and plasmid resistance to colistin (mcr-1) in bacteria isolated from Musca domestica in a garbage dump near a hospital in Lima, Peru. Bacteria with phenotypic resistance to carbapenemics were isolated on CHROMagar mSuperCARBATM medium and colistin resistance profiling was performed using the colistin disk elution method. Detection of blaKPC, blaNDM, blaIMP, blaOXA-48, blaVIM and mcr-1 genes was performed by conventional PCR. The antimicro-bial susceptibility profile was determined using the automated MicroScan system. We found that 31/38 strains had phenotypic resistance to carbapenemics and 26/38 strains had phenotypic resistance to colistin with a minimum inhibitory concentration ≥ 4 µg/ml. Finally, we identified seven bacterial strains with carbapenem resistance genes (OXA-48 and KPC) and one bacterial strain with plasmid resistance to colistin (mcr-1). One Escherichia coli strain had three resistance genes: KPC, OXA-48 and mcr-1.

Translated title of the contributionGenes resistentes a carbapenémicos y colistina aislados en Musca domestica proveniente de un basural cercano a un hospital de Lima
Original languageSpanish
Pages (from-to)164-170
Number of pages7
JournalRevista Peruana de Medicina Experimental y Salud Publica
Volume41
Issue number2
DOIs
StatePublished - Jun 2024

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