TY - JOUR
T1 - Genome analysis of 17 extensively drug-resistant strains reveals new potential mutations for resistance
AU - Guio, H.
AU - Tarazona, D.
AU - Galarza, M.
AU - Borda, V.
AU - Curitomay, R.
N1 - Publisher Copyright:
© 2014 Guio et al.
PY - 2014
Y1 - 2014
N2 - We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American-Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.
AB - We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American-Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.
UR - http://www.scopus.com/inward/record.url?scp=85003727748&partnerID=8YFLogxK
U2 - 10.1128/genomeA.00759-14
DO - 10.1128/genomeA.00759-14
M3 - Article
AN - SCOPUS:85003727748
SN - 2169-8287
VL - 2
JO - Genome Announcements
JF - Genome Announcements
IS - 4
M1 - e00759-14
ER -