Point prevalence survey of antibiotic use in hospitals in Latin American countries

Gabriel Levy Hara, Robin Rojas-Cortes, Helvert Felipe Molina León, Anahí Dreser Mansilla, Ismary Alfonso Orta, Jose Noe Rizo-Amezquita, Rene Guillermo Santos Herrera, Silvia Mendoza De Ayala, Marlen Arce Villalobos, Hilda Mantilla Ponte, Ever Davila, Gloria Aguilar, Analiá Porrás, Pilar Ramón-Pardo, Jose Luis Castro, Daniela Guzmán, Mariá Luisa Rioseco, Jaime Labarca, Jose Pablo Diáz Madriz, Josue Murillo CuberoAllan Robles Calderón, Mónica Alfaro, Luisa Arias Soto, Alejandro Aayon, Tania Jimenez Oreamuno, Zulema Jimenez, Adriana Sequeira, Jorge Mederos Hernández, Jorge Luis Campistrous Lavaut, Damarys Castillo Meriño, Elsa Fleitas Ruisanchez, Damaris Portuondo Sánchez, Humberto Guanche Garcell, Juan Jose Pisonero Socias, Evelyn Perera Diáz, Norma America Cardoso Lunar, Irene Fiterre Lancis, Jose Antonio Álvarez Ramírez, Midsay Lòpez Leyte, Ariadna Mendez Rosabal, Ebel Aldana Estrada, Mariela Cano, Leonel Mendez, Anay Cordero Eiriz, Liana Padrón Menendez, Gladys Fuentes Fernández, Raunel Reyes Ayala, Salomón Monroy, Ramón Menjívar, Carmen Elena Albanez Martínez, Diana Cabrera, Sofiá Mercedes Menjivar Delgado, Gustavo Antonio Molina Guzmán, Rafael Mejiá, Carolina Rodríguez, Sara Alvarenga, Mirian Alvarado, Ruth Del Carmen Alvarado De Zelaya, Germán Arevalo, Guillermo Parada, Luis Cuellar, Alexis Holguín Ruiz, Yuan Almora Pinedo, Eduardo Sánchez Vergaray, Luis Enrique Vasquez Gil, Bertha Gizel Injante Ibazeta, Esther Dina Guadalupe Ricra, Rony Estrada Segura, Coralith Garciá Apac, Jennifer Cuadros Inga, Roger Hernández Diáz, Marie Vallejo Vigo, Cesar Mujica Cuba, Pierina Vilcapoma, Eddie Angles-Yanqui, De Rocío Mananita Terrones, Rosa Terán Robles, Cristhian Resurrección, Alfredo Chiappe Gonzalez, Martha Antezana, Socorro Torres Zegarra, Miguel Villegas-Chiroque, Roberto Diáz-Sipión, Jorge Benítez-Peche, Jorge Luis Alave Rosas, Jhoselyn Laura Goytizolo Ruiz, Angelica Mariá Hernández Fernández, Jose Antonio Flores Vargas, Javier Araujo, Francisco Javier Arriaga Garciá, Zoila Cruz Rivera, Víctor Monroy Colín, Katia Bustamante Ríos, Jorge Israel Hernández Blanquel, Eduardo Arias De La Garza, Hector Hernández Gutierrez, Karla León, Hortencia Esther Peralta Lara, Carlos Baltodano Arias, Eduardo Alemán Garay, Gladys Estigarribia Sanabria, Livio Mereles Menchaca, Natalia Luraschi Vire, Dasy Acuña, Edgar Gimenez Caballero

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Background: Point prevalence surveys (PPSs) on antibiotic use are useful for understanding different aspects related to prescription patterns in hospitals. Methods: An adaptation of the WHO methodology for a PPS on antibiotic use was applied. Hospital wards were divided into medical (MED), surgical (SUR), ICUs, gynaecology and obstetrics (GO), high-risk (HR) and mixed wards (MIX). A web application (RedCapVC ) through a mobile device was used for data collection. Results: Between December 2018 and August 2019, 5444 patients in 33 hospitals in five countries were included (10 hospitals in Cuba, 7 in Paraguay, 6 in El Salvador, 5 in Mexico and 5 in Peru). Of these patients, 54.6%received at least one antibiotic, with variations between and within hospitals and countries. Antibiotics were more frequently used in ICUs (67.2%), SUR (64.5%) and MED wards (54.2%), with 51.2% of antibiotics prescribed for community-acquired infections (CAIs), 22.9% for healthcare-associated infections (HAIs), 11.1% for surgical prophylaxis and 6.1% for unknown reasons. Adherence to guidelines was observed in 68.6% of cases (72.8% for CAIs, 72.4% for HAIs and 44.3% for prophylaxis). Third-generation cephalosporins were the class of antibiotics most frequently used (26.8%), followed by carbapenems (10.3%) and fluoroquinolones (8%). Targeted treatments were achieved in 17.3%of cases. Conclusions: Antibiotic use was generally higher than that published in other studies. There is an urgent need to promote and strengthen the antimicrobial stewardship programmes in Latin America.

Original languageEnglish
Pages (from-to)807-815
Number of pages9
JournalJournal of Antimicrobial Chemotherapy
Volume77
Issue number3
DOIs
StatePublished - 1 Mar 2022

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