TY - JOUR
T1 - Prevalence and antimicrobial resistance of non-ESKAPE-Ec Enterobacteriales in a IV-level hospital in Lima, Peru
AU - Flores-Paredes, Wilfredo
AU - Luque, Nestor
AU - Albornoz, Roger
AU - Rojas, Nayade
AU - Espinoza, Manuel
AU - Ruiz, Joaquim
AU - Pons, Maria J.
N1 - Publisher Copyright:
© 2021 Greek Society of Microbiology Ascent Ltd. All rights reserved.
PY - 2021/4/1
Y1 - 2021/4/1
N2 - The aim of this work was to evaluate the levels and the evolution of antimicrobial resistance of non-ESKAPE-Ec Enterobacteriales (NEEcE, non Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. and Escherichia coli) from a IV-level Peruvian hospital. NEEcE accounting for >0.5% of total isolates in 2009-2010 (Period 1) and/or 2012-2014 (Period 2) were included in the study. Bacterial identification and antimicrobial resistance was performed by automated methods. Additionally, the presence of extended spectrum beta-lactamases (ESBLs) was investigated in Klebsiella oxytoca. According to our results, Citrobacter freundii, Klebsiella oxytoca, Morganella morganii, Proteus mirabilis, Providencia spp. and Serratia marcescens fulfilled inclusion criteria, accounting for 695/9918 isolates (7.0%); 238/3777 (6.30%) in Period 1 and 447/6141 (7.28%) in Period 2 (p=0.0038). P. mirabiliswas the most frequent with 192 isolates (1.94%), while only 54 Providencia spp. (0.54%) were recovered. Carbapenems were the most active antibacterial agents. In general, the microorganisms showed lower or moderate levels of resistance to amikacin and piperacillin/tazobactam, while resistance levels to the remaining antibacterial agents were >40%. Multidrug resistance (MDR) levels varied from 36.1% in S. marcescens to 73.9% in P. mirabilis. Temporal analysis showed that the levels of antibiotic resistance tended to decrease or not to vary. This finding led to a MDR decrease, except for P. mirabilis and Providencia spp. The presence of ESBL was associated with significantly higher levels of resistance to noncephalosporin antibiotics, except imipenem. In conclusion, present results demonstrate the relevance of NEEcE, highlighting the need to include these Enterobacteriales in routine followup and also warn about the worrisome panorama of antibiotic resistance in the area.
AB - The aim of this work was to evaluate the levels and the evolution of antimicrobial resistance of non-ESKAPE-Ec Enterobacteriales (NEEcE, non Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. and Escherichia coli) from a IV-level Peruvian hospital. NEEcE accounting for >0.5% of total isolates in 2009-2010 (Period 1) and/or 2012-2014 (Period 2) were included in the study. Bacterial identification and antimicrobial resistance was performed by automated methods. Additionally, the presence of extended spectrum beta-lactamases (ESBLs) was investigated in Klebsiella oxytoca. According to our results, Citrobacter freundii, Klebsiella oxytoca, Morganella morganii, Proteus mirabilis, Providencia spp. and Serratia marcescens fulfilled inclusion criteria, accounting for 695/9918 isolates (7.0%); 238/3777 (6.30%) in Period 1 and 447/6141 (7.28%) in Period 2 (p=0.0038). P. mirabiliswas the most frequent with 192 isolates (1.94%), while only 54 Providencia spp. (0.54%) were recovered. Carbapenems were the most active antibacterial agents. In general, the microorganisms showed lower or moderate levels of resistance to amikacin and piperacillin/tazobactam, while resistance levels to the remaining antibacterial agents were >40%. Multidrug resistance (MDR) levels varied from 36.1% in S. marcescens to 73.9% in P. mirabilis. Temporal analysis showed that the levels of antibiotic resistance tended to decrease or not to vary. This finding led to a MDR decrease, except for P. mirabilis and Providencia spp. The presence of ESBL was associated with significantly higher levels of resistance to noncephalosporin antibiotics, except imipenem. In conclusion, present results demonstrate the relevance of NEEcE, highlighting the need to include these Enterobacteriales in routine followup and also warn about the worrisome panorama of antibiotic resistance in the area.
KW - Klebsiella oxytoca
KW - Morganella morganii, Providencia
KW - Proteus mirabilis
KW - Serratia marcescens
KW - antimicrobial resistance Citrobacter freundii
UR - http://www.scopus.com/inward/record.url?scp=85129665297&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85129665297
SN - 0438-9573
VL - 66
SP - 155
EP - 165
JO - Acta Microbiologica Hellenica
JF - Acta Microbiologica Hellenica
IS - 2
ER -