Evidence of clonal expansion in the genome of a multidrug-resistant Mycobacterium tuberculosis clinical isolate from Peru

M. Galarza; D. Tarazona; V. Borda; J. C. Agapito; H. Guio

doi:10.1128/genomeA.e00089-14

Evidence of clonal expansion in the genome of a multidrug-resistant Mycobacterium tuberculosis clinical isolate from Peru

M. Galarza, D. Tarazona, V. Borda, J. C. Agapito, H. Guio

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Resumen

We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDRTB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R) genes. Our evidence suggests that INS-MDR may be a clonal expansion related to the African strain KZN 1435.

Idioma original	Inglés
Número de artículo	e00089-14
Publicación	Genome Announcements
Volumen	2
N.º	1
DOI	https://doi.org/10.1128/genomeA.e00089-14
Estado	Publicada - 2014
Publicado de forma externa	Sí

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title = "Evidence of clonal expansion in the genome of a multidrug-resistant Mycobacterium tuberculosis clinical isolate from Peru",

abstract = "We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDRTB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R) genes. Our evidence suggests that INS-MDR may be a clonal expansion related to the African strain KZN 1435.",

author = "M. Galarza and D. Tarazona and V. Borda and Agapito, {J. C.} and H. Guio",

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AU - Tarazona, D.

AU - Borda, V.

AU - Agapito, J. C.

AU - Guio, H.

PY - 2014

Y1 - 2014

N2 - We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDRTB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R) genes. Our evidence suggests that INS-MDR may be a clonal expansion related to the African strain KZN 1435.

AB - We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDRTB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R) genes. Our evidence suggests that INS-MDR may be a clonal expansion related to the African strain KZN 1435.

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U2 - 10.1128/genomeA.e00089-14

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Evidence of clonal expansion in the genome of a multidrug-resistant Mycobacterium tuberculosis clinical isolate from Peru

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