Producción Científica UPeU

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    Sexual Behavior and Sexually Transmitted Infection Outcomes Among Men Who Have Sex With Men and Transgender Women Participating in a Study of the Timing of Antiretroviral Therapy in Lima, Peru
    (2020-11-11)
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    Ricardo Alfaro
    ;
    Tara Ness
    ;
    Carmela Ganoza
    ;
    Pedro Gonzáles
    BACKGROUND: We assessed sexual behavior and incidence of sexually transmitted infections (STIs) among men who have sex with men and transgender women participating in Sabes, a study of an expanded treatment as prevention strategy focused on early diagnosis and treatment of HIV infection in Lima, Peru (2013-2017). METHODS: Sabes participants were tested monthly for HIV to identify acute or early infections, and HIV-positive participants were randomized to receive antiretroviral therapy immediately (immediate arm) or after 24 weeks (deferred arm) during a 48-week follow-up period. Sexual behavior was assessed at randomization (baseline) and every 12 weeks thereafter. Participants were tested for urethral and rectal chlamydia and gonorrhea and for syphilis at baseline, 12, 24, and 48 weeks. We describe patterns of sexual behavior during the 48-week follow-up period and compare sexual behavior and STI incidence between study arms. RESULTS: After randomization, 207 HIV-positive participants completed questionnaires and STI testing at 2 or more visits. After HIV diagnosis, participants in both arms reported increases in condom use with main and casual partners and decreased drug and alcohol use before or during anal sex. We observed no between-arm differences in sexual behavior. Deferred arm participants had higher incidence of chlamydia (incidence rate ratio, 2.33; 95% confidence interval, 1.14-4.77) but not gonorrhea or syphilis. CONCLUSIONS: Despite reported increases in condom use, the overall high incidence of STIs reflects some ongoing condomless sex among HIV-positive men who have sex with men and transgender women, highlighting the importance of regular STI screening and counseling to support consistent condom use among HIV-positive individuals at risk for STIs.
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    Long-term effects of early antiretroviral initiation on HIV reservoir markers: a longitudinal analysis of the MERLIN clinical study
    (2021-03-23)
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    Rachel Bender Ignacio
    ;
    Javier R. Lama
    ;
    Amélie Pagliuzza
    ;
    Sayan Dasgupta
    BACKGROUND: Early antiretroviral therapy (ART) initiation (ie, within 3 months of infection) limits establishment of the HIV reservoir. However, the effect of early ART initiation on the long-term dynamics of the pool of infected cells remains unclear. METHODS: In this longitudinal analysis, we included cisgender men who have sex with men (MSM) and transgender women (aged 18-54 years) at high risk for HIV infection, enrolled in the ongoing longitudinal MERLIN study in Peru between Oct 28, 2014, and Nov 8, 2018. Participants were eligible if they had been infected with HIV less than 90 days before enrolment, and if they had cryopreserved peripheral blood mononuclear cell (PBMC) samples. Participants were stratified into three groups on the basis of whether they initiated ART at 30 days or less (acute group), at 31-90 days (early group), or more than 24 weeks (deferred group) after the estimated date of detectable infection. PBMC samples were collected before ART initiation and longitudinally for up to 4 years on ART. The main outcomes were to establish the size of the HIV reservoir before ART initiation and to assess the effect of the timing of ART initiation on the decay of the HIV reservoir over 4 years follow-up. We quantified viral load, and isolated CD4 cells to quantify total HIV DNA, integrated HIV DNA and 2-long terminal repeat circles. Longitudinal analysis of active and inducible HIV reservoirs were measured by quantifying the frequency of CD4 cells producing multiply-spliced HIV RNA ex vivo and after in-vitro stimulation with a tat/rev induced limiting dilution assay (TILDA). A mixed-effects model from the time of ART initiation was used to measure longitudinal decays in viral loads and each HIV reservoir measure in each of the three groups. FINDINGS: We included 56 participants in this analysis, all of whom were MSM: 15 were in the acute group, 19 were in the early group, and 22 were in the deferred group. Participants in all three groups had similar levels of all HIV reservoir markers before ART initiation. All participants, including those in the acute group, had a pool of transcriptionally silent HIV-infected cells before ART initiation, as indicated by a substantial increase in TILDA measures upon stimulation. Longitudinal analysis over 4 years of ART revealed a biphasic decay of all HIV persistence markers, with a rapid initial decline followed by a slower decay in all participants. During the first-phase decay, the half-lives of both total and integrated HIV DNA and TILDA measures were significantly shorter in the acute group than in the early and deferred groups. During the second-phase decay, HIV reservoir markers continued to decline only in participants in the acute group. INTERPRETATION: Participants who initiated ART within 30 days or less of HIV infection showed a steeper and more sustained decay in HIV reservoir measures, suggesting long-term benefit of acute ART initiation on reservoir clearance. FUNDING: The US National Institutes of Health and the Canadian Institutes for Health Research.
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    Traducción, adaptación cultural, validez de contenido y constructo del cuestionario Feedback in medical education (FEEDME-Proveedor) en estudiantes de medicina humana
    (2021-01-01)
    ;
    Larissa Schunemman
    ;
    V. Andre Choroco
    ;
    Renzo Felipe Carranza Esteban
    ;
    Manuel Landa-Barzola
    "Introducción: el cuestionario Feedback in Medical Education (FEEDME-Provider) es un instrumento que mide la interacción entre el estudiante o residente de medicina con el médico que le brinda el feedback.Objetivos: el objetivo de este trabajo es traducir, adaptar culturalmente el cuestionario FEEDME-Provider al español latinoamericano, evaluar su consistencia interna y la validez de contenido y del constructo estructural.Métodos: se realizó un estudio analítico observacional de tipo instrumental en 139 estudiantes de medicina. La validez de la escala se determinó mediante el coeficiente V de Aiken y sus intervalos de confianza del 95 %. Además, se realizaron pruebas de análisis factorial y confiabilidad.Resultados: todos los valores del coeficiente V de Aiken fueron estadísticamente significativos (V > 0,70) con valores del límite inferior del IC 95 % apropiados. La asimetría y curtosis de los ítems fueron inferiores a ± 1,5. En el análisis factorial exploratorio se evidenció la existencia de 3 factores, los cuales corresponden con la estructura teórica de la escala original. Todos estos presentaron valores de saturación > 0,30. Sin embargo, el 1 el 3 se eliminaron por no corresponder teóricamente con su factor. Respecto a la confiabilidad de la escala total y sus factores, el coeficiente α de Cronbach es superior a 0,80, que indica que una escala presenta consistencia interna. Conclusiones: la adecuada traducción y adaptación cultural del contenido de los ítems produjo consistentes propiedades psicométricas (confiabilidad, validez de contenido y de constructo estructural) de las puntuaciones de la Escala de FEEDME-Proveedor en una muestra de estudiantes peruanos de medicina humana."
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    Strength of Religious Faith in Peruvian Adolescents and Adults: Psychometric Evidence from the Long and Short Version of the Santa Clara Strength of Religious Faith Questionnaire in Spanish
    (2021-03-18)
    Tomás Caycho‐Rodríguez
    ;
    Lindsey W. Vilca
    ;
    Thomas G. Plante
    ;
    Andrea Vivanco-Vidal
    ;
    Daniela Saroli-Araníbar
    The aim of this study was to evaluate the psychometric evidence of the original and brief version of the Santa Clara Strength of Religious Faith Questionnaire (SCSRFQ) in Spanish in a sample of 245 Peruvian adolescents and adults (mean age = 21.04 years, SD = 3.07, 47.8% male and 52.2% female), selected by non-probabilistic convenience sampling. Additionally, the Coronavirus Anxiety Scale and the Satisfaction with Life Scale were applied. Confirmatory Factor Analysis, internal consistency reliability methods, hierarchical sequence of variance models and Graded Response Model were used. Results indicate that both versions of the SCSRFQ showed robust psychometric properties: adequate unidimensional structure, adequate difficulty and discrimination parameters, and significant relationships with the measures of fear of COVID-19 and satisfaction with life. The original version of the SCSRFQ showed evidence of strict measurement invariance by gender and age; whereas the short version showed strict invariance by gender and configural invariance by age. Both versions showed acceptable reliability indices. In conclusion, the original and brief versions of the SCSRFQ show evidence of psychometric indicators that support their use to assess the strength of religious faith
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      13
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    MEASURING BOREDOM DURING THE COVID-19 PANDEMIC
    (2023-04-30)
    José Ventura‐León
    ;
    Tomás Caycho‐Rodríguez
    ;
    Brian Norman Peña-Calero
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    The aim of this study was to translate into Spanish and validate the Boredom Proneness Scale-Short (SBPS) in a sample of young people and adults in Peru during the COVID-19 pandemic. A total of 588 people between 17 and 53 years of age (M = 21.70; SD = 5.22) was selected as a sample. The methodology used combined Confirmatory Factor Analysis (CFA) and Item Response Theory (IRT) to determine the internal structure, factor weights and reliability, which was estimated by means of the omega coefficient test information functioning and empirical or marginal reliability. Evidence of convergent validity of the SBPS was explored based on its relationship with the Generalized Anxiety Disorder Scale (GAD-2) and Patient Health Questionnaire (PHQ-2). Results reveal that the SBPS is a measure that should be interpreted uni-dimensionally. Reliability was excellent and convergence with the GAD-2 and PHQ-2 presented the expected relationship in both magnitude and direction.
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    Academic co-creation: development and validation of a short scale
    (2023-09-21)
    José Ventura‐León
    ;
    Andy Rick Sánchez‐Villena
    ;
    Tomás Caycho‐Rodríguez
    ;
    Introduction Given the profound changes caused in higher education by the COVID-19 pandemic, affecting 1.6 billion students and 63 million educators globally, there arises the necessity for quantifiable measures that capture the essence of academic co-creation. This study aimed to develop and validate a short scale that measures academic co-creation (AC-S) in a sample of higher education students. Methods A total of 3,169 students from three Peruvian cities participated in the study (Mean Age = 25.77 years old; SD = 8.92 years); 1889 were female (59.60%) and 1,280 (40.40%) males. Qualitative and quantitative procedures were used for test construction. Item response theory (IRT) under the two-parameter graded response model (GRM-2PL) and test information function were used to examine reliability; additionally, a brief measure of academic satisfaction was used to provide evidence of relationship with another variable. Results The AC-S displayed strong fit and reliability, assessed through the test information function and standard error. It also showed a moderate correlation with academic satisfaction, bolstering its validity by linking with a pertinent variable. Its brevity enhances its practicality for education and research, efficiently fitting explanatory models and educational contexts. Despite substantial sample size and advanced psychometric methods, the study acknowledges limitations in sample representativeness and cross-sectional design. In conclusion, IRT and SEM techniques compellingly support the AC-S’s reliability and validity. Conclusion The scale’s one-dimensionality, local independence, reliability, and academic satisfaction relationship form a foundation for future exploration of co-creation-based educational models. Further studies should evaluate its performance across diverse cultural contexts.
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    VALIDATION STUDY OF THE SPANISH VERSION OF THE PANDEMIC (COVID-19) ANXIETY TRAVEL SCALE IN PERU
    (2023-10-31)
    Tomás Caycho‐Rodríguez
    ;
    José M. Tomás
    ;
    José Ventura‐León
    ;
    Pablo D. Valencia
    ;
    The COVID-19 pandemic has changed tourists' thoughts, feelings and ways of travelling. In this regard, the aim of the present study was to evaluate the psychometric properties of the Pandemic Anxiety Travel Scale (PATS) using CTT and IRT. A total of 454 participants, with a mean age of 31.4 years (SD = 15.7), completed the PATS, a sociodemographic questionnaire, a measure of perceived health risk, and the Preventive COVID-19 Infection Behaviors Scale. CFA models, Cronbach's alpha and the Composite Reliability Index coefficients were used to estimate reliability. In addition, Item Response Theory (IRT) methods were employed, specifically, the Graded Response Model. The results of the CFA indicated the presence of a single factor for the PATS and high reliability. The IRT results suggest that the PATS items may significantly differentiate responses based on trait level and that a person with low frequency of travel anxiety symptoms during the pandemic will tend to choose the lower response alternatives. Likewise, age, gender, health risk perception, and COVID-19 preventive behaviors significantly predict travel anxiety. In conclusion, the PATS is a brief and reliable measure that appears to be a valid measure of travel anxiety symptoms in the general Peruvian population during the pandemic.
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    Sample size in quantitative instrument-based studies published in Scopus up to 2022: An artificial intelligence aided systematic review
    (2023-11-01)
    Despite their popularity, quantitative instruments like Likert scales struggle with a practical issue for research projects - how many participants have to fill out the instrument? This study started with the data for 31,271 articles downloaded from Scopus and, after exclusions, reviewed the sample size used in 21,506 studies. Scimago highest quartile data was brought in for 1999-2021 and linked to the exported articles. Anthropic's Claude and Claude-Instant AI tools were used to analyze the journal article abstracts and extract the sample size information. Frequency distribution of sample size used are presented. Descriptive statistics such as maximum, average and trimmed averaged sample size values are presented by quartile of the journal where the article was published, range of years when the article was published, 3 common analyses which tend to increase sample size, and two population groups which have been shown to impact sample size. The study concludes with ranges for commonly used sample sizes based on a number of criteria. This is one of the first studies to use AI tools to assist in the analysis for a systematic review study.
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    Urea Cycle Enzymatic Abnormalities in Patients in Endogenous Hepatic Coma
    (1963-08-01)
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    María Eugenia Pino
    ;
    Jorge E. Valenzuela
    ;
    F Lorca
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