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Utility of Individual Neurocognitive Domains of the Rowland Universal Dementia Assessment Scale to Detect Cognitive Impairment in an Urban Illiterate Population
Author(s)
Universidad Privada San Juan Bautista
Marco Málaga
Instituto Peruano de Neurociencias
Diego Chambergo‐Michilot
Universidad Científica del Sur
Rosa Montesinos
Universidad de San Martín de Porres
Diego Bustamante‐Paytan
Instituto Peruano de Neurociencias
Fiorella Baca
Instituto Peruano de Neurociencias
Juan C. Carbajal-Silva
Instituto Peruano de Neurociencias
José Carlos Huilca
Instituto Peruano de Neurociencias
David Lira
Instituto Peruano de Neurociencias
Junior Senador
Instituto Peruano de Neurociencias
Eder Herrera‐Pérez
Universidad San Ignacio de Loyola
Monica M. Diaz
University of North Carolina at Chapel Hill
Serggio Lanata
University of California, San Francisco
Jorge Alarcón
National University of San Marcos
Date Issued
2 de julio de 2025
Type
Article
Volume
54
Issue
6
Series/Report No.
Dementia and Geriatric Cognitive Disorders
Start Page
1
End Page
9
ISSN
1420-8008
1421-9824
Abstract
INTRODUCTION: Brief cognitive tests like the RUDAS are useful for early detection of neurodegenerative diseases, especially in low-literacy populations in low- and middle-income countries. This study assesses the diagnostic performance of the RUDAS by subdomains to detect MCI and dementia in illiterate individuals in Lima, Peru. METHODS: We performed a secondary analysis of a cohort of randomly selected illiterate individuals, recruited for validation of RUDAS in Lima, Peru. We compared the RUDAS domain and total scores to a battery of neuropsychological tests (FDS, BDS, ROCF, MINT and Craft 21) using a Spearman correlation coefficient. For diagnostic performance, we calculated the area under the curve (AUC) for each RUDAS domain. RESULTS: We included 187 patients (64 controls, 60 MCI, and 63 dementia patients). Average RUDAS score was 23.87 ± 0.93, 20.43 ± 1.39, and 14.97 ± 2.21, respectively. Differences were statistically significant between groups for all domains, except for ideomotor praxis and visuo-spatial praxis. For convergent validity, most significant correlations from the bivariate analysis remained in the age-adjusted regression, particularly for praxis, memory, and judgment. The total RUDAS score had an AUC of 98% (95% CI: 96-100%) for both MCI and dementia, by domains, judgment, verbal fluency, and memory AUC ranging from 0.7 to 0.8. CONCLUSIONS: Our study showed the RUDAS domains of visuo-spatial orientation and memory had an excellent diagnostic performance for the detection of dementia. However, further research is needed to validate the use of individual RUDAS items for assessing specific cognitive domains.
Keywords