Body Mass Index and Bronchodilator Responsiveness in Adults: Analysis of 2 Population-Based Studies in 4 South American Countries
Author(s)
Andrés G. Lescano
Robert H. Gilman
J. Jaime Miranda
Antonio Bernabé‐Ortiz
Adolfo Rubinstein
Laura Gutiérrez
Vilma Irazola
Robert A. Wise
William Checkley
Date Issued
1 de enero de 2025
Type
Article
Volume
12
Issue
6
Start Page
477
End Page
489
Abstract
Introduction:In South America, the rise in chronic respiratory diseases and weight-related issues due to the ongoing epidemiological transition has prompted research into their interrelationship. Methods:We sought to assess the association between body mass index (BMI) and bronchodilator responsiveness (BDR) among adults in Peru, Chile, Uruguay, and Argentina, using population-based data from two cohort studies.We defined BDR as a 12% and 200 mL increase in either forced expiratory volume in one second (FEV1) or forced vital capacity (FVC) after administration of a short-acting bronchodilator.The analysis also distinguished between FEV-and FVC-specific BDR.We used logistic regression adjusted for confounders to evaluate associations with BMI.Results: Among 7,160 participants (55.2% men, mean age 57.3 years), 23.7% had a BMI <25 kg/m and 35.5% had a BMI 30 kg/m.Overall, 9.5% met the criteria for BDR; with 7.8% showing FEV1specific and 4.9% FVC-specific responses.Compared to a BMI of 20-24.9kg/m, a BMI 30 kg/m was associated with higher odds of FVC-specific BDR (adjusted OR = 1.47, 95% CI 1.08-2.03),whereas a BMI <20 kg/m was associated with FEV-specific BDR among participants with asthma (6.34, 1.16-35.1)and chronic bronchitis (4.71, 1.28-15.9),and with higher odds of any BDR in those with chronic bronchitis (3.90, 1.19-11.93). Conclusion:There was a differential relationship between BMI and types of BDR: higher BMI was associated with FVC-specific responsiveness, whereas lower BMI was linked to FEV-specific BDR in individuals with asthma and chronic bronchitis and to overall BDR in those with chronic bronchitis.
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