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Geographic Disparities in Domestic Pig Population Exposure to Ebola Viruses, Guinea, 2017–2019
Author(s)
Solène Grayo
Alimou Camara
Bakary Doukouré
Isabelle Ellis
Cécile Troupin
Kerstin Fischer
Jessica Vanhomwegen
Michaël White
Martin H. Groschup
Sandra Diederich
Noël Tordo
Date Issued
22 de marzo de 2024
Type
Article
Volume
30
Issue
4
Start Page
681
End Page
690
Abstract
Although pigs are naturally susceptible to Reston virus and experimentally to Ebola virus (EBOV), their role in Orthoebolavirus ecology remains unknown. We tested 888 serum samples collected from pigs in Guinea during 2017-2019 (between the 2013-16 epidemic and its resurgence in 2021) by indirect ELISA against the EBOV nucleoprotein. We identified 2 hotspots of possible pig exposure by IgG titer levels: the northern coast had 48.7% of positive serum samples (37/76), and Forest Guinea, bordering Sierra Leone and Liberia, where the virus emerged and reemerged, had 50% of positive serum samples (98/196). The multitarget Luminex approach confirms ELISA results against Ebola nucleoprotein and highlights cross-reactivities to glycoprotein of EBOV, Reston virus, and Bundibugyo virus. Those results are consistent with previous observations of the circulation of Orthoebolavirus species in pig farming regions in Sierra Leone and Ghana, suggesting potential risk for Ebola virus disease in humans, especially in Forest Guinea.
Keywords