Case-fatality of acute ischemic stroke in stroke units of Latin American hospitals
Author(s)
Miguel A. Barboza
Leonardo Augusto Carbonera
Virgilio E. Failoc‐Rojas
Julieta Rosales
Pablo Amaya
Pablo M. Lavados
María Álvarez
Fernando Góngora‐Rivera
Verónica V. Olavarría
Pablo A. González
Celina Ciardi
Pedro Lylyk
Juan Cirio
Natalia Llanos‐Leyton
Julián Alejandro Rivillas
Donoband Melgarejo
Analia Cardozo
Lorena Gallardo-Peralta
Andrés Silva-Pozo
Liliana Rodríguez-Kadota
Diego Canales
Sara Lorena Salvador-Mateo
Sebastián León-Vallejo
Mariángel Gabriela Vásquez Zevallos
Angelica Ruiz Franco
Natalia Balián
Marianela Soledad Lopez Armaretti
María Victoria Acosta
Ronald Alexis Soto Arancibia
Felipe Romero
Luis José Cotes Mendoza
Andrés Eduardo Diaz Guzmán
Luis Roa
Laura Boada Robayo
Loren Marcela Gallo
F Carvajal
Esteban Montoya Vera
William Bayona Pancorbo
Carla Gabriela Román Ojeda
Jorge Emilio Alfonso
Violeta Celis
Rodrigo Décima Bonaglia
María I. Rodríguez
Ramiro Rocha Rodríguez
Gonzalo Pérez
Nelson Novarro
Diana Manrique-Otero
Ana María García Callejas
Jaime Eduardo Rodriguez Orozco
Carlos Fernando Martinez Rubio
Laura Andrea Serna Corredor
Fabiola Serrano
Claudia Vanessa Cano Nigenda
Alessandra Pompa
Gisele Sampaio Silva
Eva Rocha
J M Cruz
Date Issued
15 de julio de 2025
Type
Article
Volume
34
Issue
9
Start Page
108396
End Page
108396
Abstract
BACKGROUND AND PURPOSE: The Case-fatality of acute ischemic stroke in stroke units of Latin American hospitals is a multicenter registry from various stroke centers in Latin America, exploring demographic, clinical, imaging, and functional outcomes in acute ischemic stroke (AIS) patients, with the intention of determining case-fatality rates (in-hospital, 30 and 90 days follow up) and analyzing associated risk factors. METHODS: We conducted a retrospective cohort study using data from hospitalized AIS patients over 18 years of age, collected from 27 centers in 11 Latin American countries between January 1 and December 31, 2022. The effect size was estimated using the hazard ratio (HR) and 95 % confidence intervals (95 % CI) through Cox regression models to assess the association between time to 30-day fatality event and covariates. RESULTS: A total of 2,997 patients were included. The mean age was 68.7 years and 48.1 % were women. In-hospital case-fatality was 9.42 %, 277 patients (10.2 %) died within 30 days, and 90-day case-fatality was relatively close at 353 patients (13.3 %). Complications were reported in 31.3 % of cases, most frequently infections (18.5 %). Age over 75 years (HRa=2.28), hyperglycemia (HRa=1.28), baseline status (HRa=1.61), stroke severity according to NIHSS >26 (HRa=6.11) and the presence of neurological complications (HRa=3.2) were risk factors for 30-day follow up case-fatality in these patients. CONCLUSION: AIS patients in Latin America stroke centers had an in-hospital case-fatality of 9.42 % and the 30-day case-fatality was 10.2 %. Older age, hyperglycemia, baseline status, stroke severity and neurological complications were the strongest predictors of early case-fatality. The findings underscore the need to optimize stroke management protocols in the region.
Subjects