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Viral Load Dynamics in Plasma and Semen When Antiretroviral Therapy Is Initiated During Early HIV-1 Infection
Author(s)
Angela K. Ulrich
University of Minnesota
Yixin Wang
Fred Hutch Cancer Center
Javier R. Lama
Asociación Civil Impacta Salud y Educación
Ricardo Alfaro
Socorro Harb
University of Washington
Glenda Daza
University of Washington
Sarah Holte
University of Washington
Siavash Pasalar
Fred Hutch Cancer Center
Jessica Ríos
Carmela Ganoza
Sayan Dasgupta
Fred Hutch Cancer Center
Robert W. Coombs
University of Washington
Ann Duerr
University of Washington
Date Issued
24 de noviembre de 2023
Type
Article
Volume
229
Issue
4
Series/Report No.
The Journal of Infectious Diseases
Start Page
1141
End Page
1146
ISSN
0022-1899
1537-6613
Abstract
We assessed human immunodeficiency virus (HIV) load in plasma and semen during primary HIV infection using serial samples of semen and plasma during the first 24 weeks after diagnosis in untreated participants and those who started antiretroviral therapy (ART) immediately at diagnosis. In the absence of treatment, semen viral load was >1000 copies/mL in almost all specimens (83%) collected 2-10 weeks after the estimated date of HIV acquisition and remained >1000 copies/mL in 35% of untreated participants at the last observed time point. Thus, in the absence of ART, semen viral load remained at a level consistent with transmissibility throughout primary infection.
Keywords