Effect of (+)-Cyanidanol-3 on the Changes in Liver Glutathione Content and Lipoperoxidation Induced by Acute Ethanol Administration in the Rat
Author(s)
Luis A. Videla
V. Fern aacute ndez
A. Valenzuela
Date Issued
30 de mayo de 2008
Type
Article
Volume
22
Issue
6
Start Page
343
End Page
348
Abstract
Acute ethanol administration to rats fasted overnight resulted in a significant decrease in the content of glutathione (GSH) of the liver concomitantly with a partial increase in oxidized glutathione levels, representing a net 38% decrease in total GSH equivalents. In these conditions, liver lipoperoxidation is significantly enhanced. Treatment with (+)-cyanidanol-3 prior to ethanol ingestion was able to reduce by 80% the ethanol-induced depletion in total GSH equivalents and to completely abolish lipoperoxidation. These results indicate that (+)-cyanidanol-3 has a protective effect on the changes in liver GSH levels and lipoperoxidation induced by ethanol, probably related to its scavenging action exerted on free radicals.
Subjects