EVOLUTION OF THE PREVALENCE AND ANTIMICROBIAL RESISTANCE AMONG Escherichia coli ISOLATED AS A CAUSE OF INFECTION IN PATIENTS ADMITTED TO A IV-LEVEL HOSPITAL IN LIMA, PERU

Flores-Paredes, Wilfredo; Luque Chipana, Nestor Alejandro; Albornoz Toyohama, Roger Hiroshi; Rojas, Nayade; Espinoza, Manuel; Ruiz, Joaquim; Pons, María Jesus

doi:10.5216/rpt.v51i3.74360

EVOLUTION OF THE PREVALENCE AND ANTIMICROBIAL RESISTANCE AMONG Escherichia coli ISOLATED AS A CAUSE OF INFECTION IN PATIENTS ADMITTED TO A IV-LEVEL HOSPITAL IN LIMA, PERU

Author(s)

Flores-Paredes, Wilfredo

Hospital Base Guillermo Almenara Irigoyen

Luque Chipana, Nestor Alejandro

Universidad Peruana Unión

Albornoz Toyohama, Roger Hiroshi

Universidad Peruana Unión

Rojas, Nayade

Ministry of Health

Espinoza, Manuel

Instituto Nacional de Salud

Ruiz, Joaquim

Universidad Científica del Sur

Pons, María Jesus

Universidad Científica del Sur

Date Issued

19 de octubre de 2022

Type

Article

Publisher

Brazilian Society of Parasitology

Volume

51

Issue

3

Series/Report No.

Revista de Patologia Tropical / Journal of Tropical Pathology

Contained in

Journal of Tropical Pathology

DOI

10.5216/rpt.v51i3.74360

ISSN

0301-0406

Abstract

The levels and evolution of antimicrobial resistance of Escherichia coli during 01/2009-06/2010 (Period 1), 01/2012-06-2013 (Period 2) and 07/2013-12/2014 (Period 3) were analyzed. Identification, susceptibility levels to 13 antibiotics and the presence of extendedspectrum β-lactamases (ESBLs) were determined. Overall, 9,918 microorganisms were isolated as a cause of infection. Of these 3,016 (30.4%) were E. coli, with 1,770 (59%), 992 (33%) and 254 (8%), from the Medicine and the Surgery Departments and the Intensive Care Unit (ICU), respectively. There was a significant increase (p=0.0002) of E. coli throughout considered periods. The isolates presented high levels of resistance (>60%) to cephalosporins, ciprofloxacin and cotrimoxazole, being only susceptible to imipenem (0.3% of resistance) and tigecycline. Overall the analysis of evolution of antimicrobial resistance showed that resistance to cephalosporins and amikacin significantly increased, while, the ones of piperacillintazobactam, cotrimoxazole and gentamicin had significantly decreased. Nevertheless, the ICU isolates showed an inverse scenario for cephalosporins. These findings agree with an increase of ESBLs on the Medicine (56% to 66%; p<0.0001) and on the Surgery (54% to 62%; p=0.0197) departments, with a parallel decrease in the ICU (76% to 68%). In summary, high levels of antimicrobial resistance have been reported among E. coli, with worrisome levels of ESBL. A continuous surveillance of antimicrobial resistance levels in the area is needed. KEY WORDS: Escherichia coli; antimicrobial resistance; cephalosporins

Financiamiento(s)

08-2019-FONDECYT

Sponsor(s)

We thank Donna Pringle for the language correction. Funding: JR was supported by Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica (FONDECYT - Perú) and Universidad Científica del Sur within the “Proyecto de Mejoramiento y Ampliación de los Servicios del Sistema Nacional de Ciencia, Tecnología e Innovación Tecnológica” [contract: 08-2019-FONDECYT-BM-INC-INV”].