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blaOXA−51-Negative Acinetobacter calcoaceticus–baumannii Complex as a Cause of Human Infection in Peru
Author(s)
Oporto-Llerena, Rosario
Universidad Científica del Sur
Huerto-Huanuco, Rosario
Universidad Científica del Sur
Quispe-Hualpa, Yaneth
Universidad Científica del Sur
Palomino-Kobayashi, Luciano A.
Universidad Científica del Sur
Soza, Gabriela
Rojas-Jaimes, Jesús Eduardo
Universidad Científica del Sur
Gonzales, Patricia
Pollack, Luis
Gomez, Andrea C.
Salvador-Luján, Gina
National University of San Marcos
Cuaresma, Edwin
Casapia, Martin
Universidad Nacional de la Amazonía Peruana
Arteaga-Livias, Kovy
Universidad de Huánuco
Sáenz, Yolanda
Center for Biomedical Research of La Rioja
Pons, María Jesus
Universidad Científica del Sur
Ruiz, Joaquim
Universidad Científica del Sur
Date Issued
1 de enero de 2025
Type
Article
Publisher
John Wiley and Sons Ltd
Volume
2025
Issue
1
Series/Report No.
Journal of Tropical Medicine
Contained in
Journal of Tropical Medicine
ISSN
1687-9686
Abstract
Background Common identification techniques do not differentiate among members of the Acinetobacter calcoaceticus–baumannii (ACB) complex, and the presence of non‐ baumannii Acinetobacter is often misinterpreted. The l a OXA−51 gene is located within the chromosome of Acinetobacter baumannii . Despite its plasmid dissemination to other members of the genus, it may be considered in initial species screening. Thus, this study aimed to determine the presence of l a OXA−51 ‐negative Acinetobacter spp. as a cause of infection in Peru. Methods Two hundred ninety‐eight ACB complex isolates from different regions of Peru were isolated between January 2018 and March 2024. Of these, 272 and 25 were confirmed as hospital‐acquired and community infections, respectively. The presence of l a OXA−51 was determined by polymerase chain reaction, and the susceptibility levels to 12 antimicrobial agents were determined. Results The results showed that 38 (12.7%) isolates were l a OXA−51 ‐negative. These isolates were frequent among community infections (13/25, p < 0.0001), often causing urine infections. They showed significantly lower levels of resistance to almost all antimicrobial agents tested, and most of them were recovered from regions outside metropolitan Lima. Conclusion A relevant number of infections by non‐ baumannii Acinetobacter species in Peru is suggested, highlighting the need for systematic identification of these species in the country.
Financiamiento(s)
PE501082454-2023
Sponsor(s)
Funding text 1: This study was supported by the Programa Nacional de Investigaci\u00F3n Cient\u00EDfica y Estudios Avanzados (PROCIENCIA, Peru) under the financial scheme \u201CE041-2023-001-Proyectos de Investigaci\u00F3n B\u00E1sica\u201D (contract: PE501082454-2023-PROCIENCIA) and Universidad Cient\u00EDfica del Sur (project 059-2023-PRO99), and developed within the frame of the net 221RT0113 from the Programa Iberoamericano\u200B de Ciencia y Tecnolog\u00EDa para el Desarrollo (CYTED). The authors would like to thank the Members of the Research Group on Peruvian Acinetobacter spp. (RPGA): Zulema Surichaqui-Cerr\u00F3n (Research Group on Dynamics and Epidemiology of Antimicrobial Resistance\u2014\u201COne Health,\u201D Universidad Cientifica del Sur, Lima, Per\u00FA; Microbiology Service, Instituto Nacional Materno Perinatal, Lima, Peru); Maria R. Chirinos (Microbiology Service, Instituto Nacional Materno Perinatal, Lima, Peru); Luis Casta\u00F1eda (Faculty of Health Sciences, Universidad Privada del Norte, Lima, Peru); Delza Tarraga Gonzales and Elsa Nu\u00F1ez Infanz\u00F3n (Microbiology Service, Hospital Nacional Guillermo Almenara Irigoyen, ESSALUD, Lima, Peru); Carmen Valera-Krumdieck (Clinical Pathology Service, Microbiology Area, Hospital Maria Auxiliadora, Lima, Peru); Katherine Alcedo and William Villegas Quispe (Laboratory of Microbiology, Hospital Nacional PNP Luis N. S\u00E1enz, Lima, Peru); Alejandra Vizcarra and Joseph Pinto (Center for Basic and Translationa