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Exploring the Link Between Hepatitis A and B Vaccination and Social Support in the US Population: Insights from the NHANES 2005-2006 Cohort
Author(s)
Bancovsky, Daniel
Sheba Medical Center
Shastry, Manjushree
IQVIA (India)
Caccamo, Martina
Ospedale A. Perrino
Vásquez-Pérez, Omar E.
Avellanet, Merce
Chapagain, Kumud
B.P. Koirala Institute of Health Sciences
Soares, Rebecca
Harvard University
Coyoy-Say, Magali
Universidad de San Carlos de Guatemala
Nguyen, Hoang
Calit, Juliana
Universidade de São Paulo
Qudayr, Asma
Taif University
Sharma, Rintu
Princess Margaret Cancer Centre
Borborema, Cynthia L. P.
Fleury S.A. (Brazil)
Grupo Fleury, São Paulo, Brazil
Irrua Specialist Teaching Hospital
Oiwoh, Sebastine
Dal Bianco, Beatrice
Real Hospital Português
Lopes, Maria Antonieta
Real Hospital Português
Nunez-Rocha, Ricardo E.
Faculdade São Leopoldo Mandic
Magalhaes, Maria
Faculdade São Leopoldo Mandic
São Leopoldo Mandic, Campinas, Brazil
Hospital Alemão Oswaldo Cruz
Alsatou, Faiez
University of Cuenca
Duarte, Felipe
McLean Hospital
Rodriguez, Jessica
University of Cuenca
Universidad de Cuenca, Ecuador
Universidade de Caxias do Sul
Genc, Ilgin
McLean Hospital
Ramos, Walter
Peace Corps
Kleber, Fabricio
Pontificia Universidad Católica Madre y Maestra
Rioja, Patricia
Instituto Nacional de Enfermedades Neoplásicas
Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru
Faculdade São Leopoldo Mandic
Montealegre, Ignacio
Peace Corps
Cabral, Isabel
Pontificia Universidad Católica Madre y Maestra
Republic, Pontificia Universidad Catolica Madre y Maestra Campus Santiago. Dominican
Beth Israel Deaconess Medical Center
Viola, Luiz
Universidade Federal de São Paulo
Grohmann, Barbara
Sarah Network of Rehabilitation Hospitals
Faculdade São Leopoldo Mandic, Campinas, Brazil
Huynh, Yoldyz
Kazan State Medical University
Vidoto, Lucas
Hapvida, Brazil
Ramirez, Arantxa
Beth Israel Deaconess Medical Center
Chin, Anny Christina
Syneos Health, functional serviceprovider dedicated to AbbVie, São Paulo, Brazil
Carvalho, Alessandra
Sarah Network of Rehabilitation Hospitals
Date Issued
26 de septiembre de 2025
Type
Article
Volume
11
Series/Report No.
Principles and Practice of Clinical Research Journal
ISSN
2378-1890
Abstract
Background: High social support is easily assessed and associated with a healthier lifestyle, including vaccination adherence. Similarly, immunization is a widely available public health statistic associated with healthier behaviors. However, the link between the hepatitis immunization status and social support needs to be explored. Methods: We assessed the association between levels of social support and hepatitis immunization status using the National Health and Nutrition Examination Survey (NHANES), a cross-sectional multidisciplinary database publicly available for researchers. With 2005–2006 data, 2997 participants were included. Statistical analyses were conducted using STATA18.5v software, including the odds ratio of both univariable logistic regression and multivariable logistic regression. After adjusting for clinically relevant confounders, two distinct models were designed: 1) full immunization, and 2) incomplete immunization. Results: Multivariable analysis revealed significantly greater odds of high social support for participants fully or partially immunized against both hepatitis A and B: 3.15 (95% CI 1.03–9.66,p=0.04) and 3.35 (95% CI 1.15–9.75,p=0.03), respectively. Conclusion: Our findings show an association between vaccination and social support in both adjusted models. Individuals not vaccinated at all may behave differently from those willing to be, at least partially, immunized. It seems that a similar behavior that may lead to vaccination may also lead to increased social support. Therefore, our study suggests that hepatitis vaccination could perhaps be a surrogate marker for public-health-related outcomes.