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Emergence of carbapenem-resistant Pseudomonas aeruginosa ST179 producing both IMP-16 and KPC-2: a case study of introduction from Peru to Spain
Author(s)
Universitat Autònoma de Barcelona
Carlos Lopera
Hospital Clínic de Barcelona
Andrea Vergara
Centro de Investigación Biomédica en Red
Ignasi Roca
Centro de Investigación Biomédica en Red
Jordi Vilà
Centro de Investigación Biomédica en Red
Climent Casals‐Pascual
Centro de Investigación Biomédica en Red
José Antonio Martínez
Centro de Investigación Biomédica en Red
Carolina García‐Vidal
Centro de Investigación Biomédica en Red
Àlex Soriano
Centro de Investigación Biomédica en Red
Cristina Pitart
Hospital Clínic de Barcelona
Date Issued
10 de mayo de 2024
Type
Article
Volume
12
Issue
6
Series/Report No.
Microbiology Spectrum
Start Page
e0061424
End Page
e0061424
ISSN
2165-0497
Abstract
ABSTRACT We describe four cases of a novel carbapenem-resistant Pseudomonas aeruginosa ST179 clone carrying the bla KPC-2 or bla KPC-35 gene together with bla IMP-16 , imported from Peru to Spain and isolated from leukemia patients. All isolates were multidrug-resistant but remained susceptible to fosfomycin, cefiderocol, and colistin. Whole-genome sequencing revealed that bla KPC-2 and bla KPC-35 were located in an IncP6 plasmid, whereas bla IMP-16 was in a chromosomal type 1 integron. This study highlights the global threat of multidrug-resistant P. aeruginosa clones and underscores the importance of monitoring and early detection of emerging resistance mechanisms to guide appropriate treatment strategies. The importation and spread of such clones emphasize the urgent need to implement strict infection control measures to prevent the dissemination of carbapenem-resistant bacteria. IMPORTANCE This is the first documented case of a Pseudomonas aeruginosa ST179 strain carrying the blaKPC-35 gene, and it represents the first report of a P. aeruginosa co-harboring blaIMP-16 and either blaKPC-2 or blaKPC-35, which wre imported from Peru to Spain, highlighting a threat due to the capacity of spreading carbapenem-resistance via plasmid conjugation.
Keywords