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Sensitivity to fosfomycin in extended-spectrum beta-lactamase-producing Escherichia coli
Author(s)
Lifonzo-Mucha, Sheyber J.
Federico Villarreal National University
Tamariz-Zamudio, Paula E.
Federico Villarreal National University
Date Issued
23 de marzo de 2018
Type
Article
Publisher
Instituto Nacional de Salud biomedica@ins.gov.co
Volume
35
Issue
1
Series/Report No.
Revista Peruana de Medicina Experimental y Salud Pública
Contained in
Revista Peruana de Medicina Experimental y Salud Publica
Start Page
68
End Page
71
ISSN
1726-4634
Abstract
Urinary infections are caused mainly by Escherichia coli (E. coli); indiscriminate use of antibiotics has caused an increase in infections due to extended-spectrum beta-lactamase (ESBL)-producing strains. Aiming to determine the sensitivity to fosfomycin, a study was conducted in ESBL-producing E. coli strains isolated from urine cultures at a hospital in Peru. Two hundred and sixty-six (266) strains of E. coli were collected, which were determined by conventional methods to be ESBL- producing. Sensitivity to fosfomycin was determined through minimum inhibitory concentration with the agar dilution method and the diffusion disc method. One hundred and ninety-two (192) (72.2%) strains of ESBL-producing E. coli strains sensitive to Fosfomycin were found. It, therefore, follows that fosfomycin exhibits antimicrobial activity against ESBL-producing E. coli strains and that it could be considered a good treatment option for resistant strains.