Soriano Moreno, Anderson Nelver Elías

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Soriano Moreno, Anderson Nelver Elías
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andersonsoriano@upeu.edu.pe
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  • Publicacion
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    Home-Based Respiratory Physiotherapy and Telephone-Based Psychological Support for COVID-19 Survivors in Peru: Protocol for a Randomized Controlled Trial
    (2022-08-02)
    Anderson N. Soriano-Moreno  
    ;
    Elaine C. Flores
    ;
    Stella M. Hartinger
    ;
    Claudia Y Mallma
    ;
    Arnold A Diaz
    BACKGROUND: Both pulmonary and mental health are affected following hospitalization for COVID-19 pneumonia. Pulmonary rehabilitation therapy has demonstrated benefits in improving mental health, but no validated combined programs that include mental health have been proposed. OBJECTIVE: This article presents the design of a trial that aimed to assess whether the participation in a combined rehabilitation program that includes home-based respiratory physiotherapy and telephone-based psychological support is associated with a greater improvement of pulmonary and mental health outcomes 7-12 weeks after COVID-19 hospitalization discharge compared with posthospital usual care provided by a public Peruvian hospital. METHODS: WAYRA (the word for air in the Quechua language) was an open-label, unblinded, two-arm randomized controlled trial. We recruited 108 participants aged 18-75 years who were discharged from the hospital after COVID-19 pneumonia that required >6 liters/minute of supplemental oxygen during treatment. Participants were randomly assigned at a 1:1 ratio to receive the combined rehabilitation program or usual posthospital care provided by a public Peruvian hospital. The intervention consisted of 12 at-home respiratory rehabilitation sessions and 6 telephone-based psychological sessions. The primary outcome was the 6-minute walk distance. Secondary outcomes included lung function, mental health status (depression, anxiety, and trauma), and quality of life. Outcomes were assessed at baseline (before randomization) and at 7 and 12 weeks after hospital discharge to assess the difference between arms. RESULTS: This study was funded by the Peruvian National Council of Science Technology and Technology Innovation in July 2020. Ethics approval was obtained on September 2, 2020. Recruitment and data collection occurred between October 2020 and June 2021. Results are expected to be published by the end of 2022. CONCLUSIONS: WAYRA was the first randomized controlled trial evaluating combined pulmonary-mental health rehabilitation for hospitalized COVID-19 survivors in resource-limited settings, potentially providing a foundation for the cost-effective scale-up of similar multidisciplinary rehabilitation programs. TRIAL REGISTRATION: ClinicalTrials.gov NCT04649736; https://clinicaltrials.gov/ct2/show/NCT04649736. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR1-10.2196/36001.
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    Percepciones e intención de los padres de vacunar a sus hijos bajo 12 años de edad contra la COVID-19: estudio transversal en Perú
    (2022-06-01)
    Jose Armando Gonzales Zamora
    ;
    David R. Soriano‐Moreno
    ;
    Anderson N. Soriano-Moreno  
    ;
    Linda Ponce-Rosas
    ;
    Abraham De-Los-Ríos-Pinto
    BACKGROUND: Despite the proven efficacy and safety of COVID-19 vaccines, pediatric vaccination coverage remains low in many countries. There are still doubts and fears in parents about vaccination in their children under 12 years of age. AIM: To evaluate the perceptions and intention of parents to vaccinate their children under 12 years of age. METHODS: Analytical cross-sectional study based on an online survey that evaluated the parents' perceptions regarding the risk of COVID-19 infection, the need for a vaccine, and the vaccine adverse events in their children under 12 years. We assessed the factors associated with the intention to vaccinate through crude (cPR) and adjusted prevalence rates (aPR), with confidence interval of 95% (CI 95%). RESULTS: 83.5% of respondents had the intention to vaccinate their children under 12 years of age. In the multivariate analysis, the factors associated with a decrease in the intention to vaccinate were to believe that the vaccine was not necessary (aPR 0.65; 95% CI 0.44 - 0.94), that it would not protect (aPR: 0.14; 95% CI 0.03 - 0.63), it would not be safe (aPR: 0.80; 95% CI 0.70 - 0.92) and it would cause long-term side effects (aPR: 0.92; 95% CI 0.85 - 1.00). On the other hand, living on the highlands or jungle was associated with an increase in the intention. CONCLUSION: In Peru, 16.5% of parents would not vaccinate their children under 12 years of age, because they perceived that the vaccine was not necessary and would not protect against COVID-19. In addition, they expressed concerns about the development of possible adverse events.
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    Percepciones e intención de los padres de vacunar a sus hijos menores de 12 años contra la COVID-19: Estudio transversal en Perú
    (2022-01-11)
    Jose Armando Gonzales Zamora
    ;
    David Soriano Moreno
    ;
    Anderson N. Soriano-Moreno  
    ;
    Linda Ponce-Rosas
    ;
    Abraham De-Los-Ríos-Pinto
    Objetivos: Evaluar las percepciones e intención de los padres de vacunar a sus hijos menores de 12 años en Perú.
 Metodología: Estudio transversal analítico a partir de una encuesta en línea (25 de noviembre al 6 de diciembre del 2021) para padres de niños menores de 12 años que recopiló la percepción sobre el riesgo de contagio por COVID-19 en sus hijos, sobre la necesidad de vacunación y sobre los eventos adversos relacionados con la vacuna. Evaluamos los factores asociados a la intención de vacunación mediante razones de prevalencia crudas (RPc) y ajustadas (RPa) con intervalos de confianza al 95% (IC 95%).
 Resultados: El 83.5% de los padres tenían la intención de vacunar a sus hijos menores de 12 años. En el análisis multivariado, los factores asociados a una disminución de la intención de vacunación fueron pensar que la vacuna no es necesaria (RPa: 0.65; IC 95% 0.44 – 0,94), que no protegería (RPa: 0.14; IC 95% 0.03 – 0.63), que no sería segura (RPa: 0.80; IC 95% 0.70 – 0.92) y que ocasionaría efectos negativos a largo plazo (RPa: 0.92; IC 95% 0.85 – 1.00). Por otro lado, residir en la Selva (RPa: 1.09; IC 95%: 1.03 – 1.15) o en la Sierra (RPa: 1.06; IC 95%: 1.00 – 1.11) se asoció a una mayor prevalencia de intención.
 Conclusiones: En Perú, un 16.5% de padres no vacunaría a sus hijos menores de 12 años, ya que perciben que la vacuna no es necesaria y no protegería contra la COVID-19, además de tener la preocupación de posibles eventos adversos.
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    Knowledge and Perceptions about Diagnosis, Clinical Management, and Prevention of Dengue Fever among Physicians during the 2023 Outbreak: A Cross-Sectional Study in Peru
    (2024-08-27)
    Julieta M. Araoz-Salinas
    ;
    Brando Ortiz-Saavedra
    ;
    Anderson N. Soriano-Moreno  
    ;
    Martín E. Reategui-Garcia
    ;
    Carlos Quispe‐Vicuña
    The objective of this study was to evaluate the knowledge level and perception of dengue fever management among Peruvian physicians and to determine the factors associated with higher knowledge. We conducted an analytical cross-sectional study based on an online survey. To evaluate the factors associated with a high level of knowledge (≥70% of correct answers), we used crude (cPR) and adjusted (aPR) prevalence ratios by the Poisson regression model. Of 359 respondents (median age: 33 years; male: 56.5%), 78.8% achieved a high level of knowledge. Multivariable analysis showed an independent association with having read the Peruvian clinical practice guidelines for dengue management (aPR: 1.29; 95% CI: 1.12-1.49), having experience in treating patients (aPR: 1.32; 95% CI: 1.03-1.68), and having treated cases frequently (aPR: 1.22; 95% CI: 1.02-1.46). Residing in the eastern macroregion (aPR: 0.83; 95% CI: 0.71-0.97) was associated with a low level of knowledge. In conclusion, Peruvian physicians had a high level of knowledge about dengue fever. This was associated with having clinical experience in dengue management. However, given the low level of knowledge in the eastern macroregion, educational campaigns are necessary in this area.
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    Metabolic syndrome as a risk factor for peripheral arterial disease: a systematic review and meta-analysis
    (2022-03-01)
    Jared Fernandez-Morales
    ;
    Sebastian A. Medina-Ramírez
    ;
    David R. Soriano‐Moreno
    ;
    Abdiel H. Coico-Lama
    ;
    Anderson N. Soriano-Moreno  
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    COVID-19 among Amazonian indigenous in Peru
    (2022-01-01)
    Anderson N. Soriano-Moreno  
    Data of the paper "COVID-19 among Amazonian indigenous in Peru: mortality, incidence, and clinical characteristics"
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    Emergence of carbapenem-resistant <i>Pseudomonas aeruginosa</i> ST179 producing both IMP-16 and KPC-2: a case study of introduction from Peru to Spain
    (2024-05-10)
    Joaquim Viñes  
    ;
    Carlos Lopera
    ;
    Andrea Vergara
    ;
    Ignasi Roca
    ;
    Jordi Vilà
    ABSTRACT We describe four cases of a novel carbapenem-resistant Pseudomonas aeruginosa ST179 clone carrying the bla KPC-2 or bla KPC-35 gene together with bla IMP-16 , imported from Peru to Spain and isolated from leukemia patients. All isolates were multidrug-resistant but remained susceptible to fosfomycin, cefiderocol, and colistin. Whole-genome sequencing revealed that bla KPC-2 and bla KPC-35 were located in an IncP6 plasmid, whereas bla IMP-16 was in a chromosomal type 1 integron. This study highlights the global threat of multidrug-resistant P. aeruginosa clones and underscores the importance of monitoring and early detection of emerging resistance mechanisms to guide appropriate treatment strategies. The importation and spread of such clones emphasize the urgent need to implement strict infection control measures to prevent the dissemination of carbapenem-resistant bacteria. IMPORTANCE This is the first documented case of a Pseudomonas aeruginosa ST179 strain carrying the blaKPC-35 gene, and it represents the first report of a P. aeruginosa co-harboring blaIMP-16 and either blaKPC-2 or blaKPC-35, which wre imported from Peru to Spain, highlighting a threat due to the capacity of spreading carbapenem-resistance via plasmid conjugation.
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    Asociación entre trastorno depresivo y deterioro cognitivo en ancianos de tres ciudades del Perú
    (2018-02-05)
    Jennifer Vilchez‐Cornejo
    ;
    Anderson N. Soriano-Moreno  
    Objetivos: Determinar la asociación entre la presencia de trastorno depresivo y trastornos neurocognitivos en adultos mayores de tres ciudades del Perú. Materiales y métodos: Estudio transversal analítico, se realizó un muestreo no aleatorizado. Se consideró a aquellos adultos mayores de 60 años, provenientes de las ciudades de Ucayali, Ica y Lima. Durante los meses de marzo a mayo del 2016 se evaluó la presencia de trastorno depresivo y deterioro cognitivo mediante el uso de las escalas de Yesevage (GDS) y de Pfeiffer, respectivamente. Resultados: Se encuestaron a 267 adultos mayores, el 58,4% fueron varones; la edad media fue de 75,4 ± 7,6 años. El 36,3% presentó deterioro cognitivo y el 64% tenía depresión moderada o severa. Además, se encontró una relación entre la edad y depresión (p&lt;0,05), y una asociación entre el deterioro cognitivo y tener depresión severa (RP [razón de prevalencias]: 2,1; intervalo de confianza al 95% [IC95%]: 1,4-3,2), tener entre 80 a 89 años (RP: 1,9; IC95%: 1,2-3,1) y proceder de Ucayali (RP=1,67; IC=1,21-2,31). Conclusión: En los pacientes evaluados, los índices de depresión aumentaron conforme aumentaba la edad y hubo una mayor probabilidad de tener trastorno neurocognitivo en aquellos con depresión severa.
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    Association between teenage mothers and acute infections in children under five in Peru from 2015-2019
    (2024-01-01)
    Jerry K. Benites‐Meza
    ;
    Percy Herrera‐Añazco
    ;
    Nilton Yhuri Carreazo
    ;
    Guido Bendezú-Quispe
    ;
    Anderson N. Soriano-Moreno  
    Abstract Objectives: to assess the association between mothers age and the presence of acute respiratory infections (ARIs) and acute diarrhea (AD) in Peruvian children under five years old. Methods: secondary analysis of the database of the “Demographic and Family Health Survey” of 2015 and 2019. We analyzed data from children under five and their reproductive-age mothers who live in the same household. Poisson regression models were used to generate adjusted prevalence ratios (aPR) with 95% confidence intervals (95%CI) to assess the association between mothers’ age group and the presence of ARIs and AD in their children. Results: 84,671 mother/child data were analyzed. In the adjusted regression model, being a young mother (aPR= 1.18; 95%CI= 1.11-1.25; p&lt;0.001) or an teenage (aPR= 1.11; 95%CI= 1.01-1.22; p=0.045) were associated with a higher prevalence of ARIs in their children. In addition, being a young mother a teenage (aPR= 1.18; 95%CI= 1.11-1.25; p&lt;0.001) or a teenage (aPR= 1.22; 95%CI= 1.10-1.35; p&lt;0.001) were also associated with a higher prevalence of AD cases in their children. Conclusions: mothers’ age was found to be associated with the prevalence of ARIs and AD in Peruvian children under five, with teenagers and young mothers having the greatest probability of ARIs and AD.
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    A Systematic Review of the Frequency of Persistent Constitutional and Respiratory Symptoms Related to COVID-19: A New Long COVID Syndrome?
    (2021-05-01)
    A.N. Soriano-Moreno  
    ;
    David R. Soriano‐Moreno
    ;
    Niels Pacheco‐Barrios
    ;
    Aimé Lescano
    ;
    William Checkley
    Rationale: The long-term consequences of COVID-19 infection on hospitalized patients remains unknown. We sought to conduct a systematic review to summarize what is known about long term sequelae among patients who were hospitalized for severe COVID-19 pneumonia. Methods: We conducted a search in MEDLINE and MedRxiv through December 15, 2020, using the search terms: “COVID-19”, “Constitutional symptoms”, “COVID- 19 Sequelae”, “Long-term COVID-19” and “Respiratory symptoms.” Articles were evaluated independently by two authors. We then extracted to perform a quantitative synthesis of available evidence and scored studies for quality using the NIH quality assessment Tool for Observational Cohort and Cross-Sectional Studies. Results: We identified 12 studies: nine published articles and three preprints. We obtained data for 4693 patients: 11 studies included hospitalized patients, 8 included ICU patients and 5 included outpatients. Follow-up time ranged from 16 days to 122 days post-hospitalization. The pooled prevalence of persistent constitutional and respiratory symptoms was: (45.6%), dyspnea (35.5%), cough (26.4%), joint pain (26.8%), myalgia (23.3%), headache (22.2%), and chest pain (20.5%). Heterogeneity across studies was high (I2>90%). Chinese studies reported a lower frequency of persistent symptoms compared with studies carried out in Western countries (e.g., France, Italy, USA, UK). There were no significant differences in long-term sequelae between ICU and non-ICU patients. Conclusion: The prevalence of persistent constitutional and respiratory symptoms in patients infected with COVID-19 is high. Addressing the burden of symptoms that reduce the quality of life is critical in COVID-19 patients.
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