Producción Científica UPeU

URI permanente para esta comunidadhttps://cris.upeu.edu.pe/handle/123456789/1

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Fecha de finalización: 1997search.filters.applied.f.perucrisaccess: search.filters.perucrisaccess.open access

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    Alcohol and Amino Acid Transport in the Human Small Intestine
    (1969-06-01)
    Yedy Israel
    ;
    Jorge E. Valenzuela
    ;
    Inés Salazar
    ;
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    Effects of Ethanol on Hepatic Blood Flow in the Rat
    (1981-03-01)
    H Iturriaga
    ;
    Daniel Bunout
    ;
    Margarita Petermanri
    ;
    ;
    Yedi Israel
    Hepatic blood flow measured by indocyanine green clearance was studied in rats after an acute intoxicating dose of ethanol (2 g/kg) or after chronic ethanol administration by feeding with alcohol liquid diets. Acute intoxication to normal animals did not modify hepatic blood flow. In chronically alcohol-fed rats, hepatic blood flow was significantly decreased when measured after 15 hr of abstinence. If ethanol was not withdrawn and an acute dose of ethanol was given before the indocyanine green clearance, a decreased hepatic blood flow was not observed. It is suggested that the reduction of hepatic blood flow in recently abstinent chronically alcohol-treated animals is related to the withdrawal syndrome.
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    Nutritional status of alcoholic patients: it's possible relationship to alcoholic liver damage
    (1983-09-01)
    Daniel Bunout
    ;
    V Gattás
    ;
    H Iturriaga
    ;
    Carla Perez
    ;
    T Pereda
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    Content of Hepatic Reduced Glutathione in Chronic Alcoholic Patients: Influence of the Length of Abstinence and Liver Necrosis
    (1984-03-01)
    Luis A. Videla
    ;
    H Iturriaga
    ;
    María Eugenia Pino
    ;
    Daniel Bunout
    ;
    Alfonso Valenzuela
    1. The relationship between the content of hepatic reduced glutathione (GSH) and the length of abstinence was investigated in 45 chronic alcoholic patients. 2. Hepatic GSH levels were significantly correlated (r = 0.58; P<0.001) with the length of alcohol withdrawal in the whole group. According to liver histology patients were divided into two groups, with and without hepatic necrosis. Subjects without necrosis showed a significant positive correlation (r = 0.71; P<0.001) between GSH values and the length of abstinence; no correlation (r = −0.22; P<0.40) was observed in the group with necrosis. 3. According to the period of abstinence patients were separated into two groups, with a short (≪ 5 days) and a prolonged (> 5 days) alcohol withdrawal. Patients with and without necrosis exhibited comparable mean levels of liver GSH (2.04 ± sem 0.21 and 1.74 ± 0.23 μmol/g respectively; P<0.30) when studied after short periods of abstinence. Alcoholics without liver necrosis showed significantly higher hepatic GSH levels than those with necrosis (3.23 ± 0.30 and 1.60 ± 0.33 respectively; P < 0.01) after prolonged periods of alcohol withdrawal. Similar results were obtained when liver GSH levels were expressed as a function of the mean surface area of hepatocytes, which was not significantly different between patients with and without hepatic necrosis. 4. Parameters assessing the nutritional status of patients with and without necrosis were not significantly different. Steatosis, histologically scored and irrespective of the period of abstinence, was higher in patients with liver necrosis and it did not correlate with hepatic GSH (r = −0.17; not significant). Fibrosis was observed in 20 cases and it did not modify the positive correlation between liver GSH content and the period of abstinence (with fibrosis: r = 0.57; P < 0.01; without fibrosis: r = 0.58;P < 0.01). 5. The changes observed in liver GSH content might be of pathogenic importance in alcoholic liver disease through alterations in lipoperoxidative processes in the hepatocyte.
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    Glucose Turnover Rate and Peripheral Insulin Sensitivity in Alcoholic Patients without Liver Damage
    (1989-01-01)
    Daniel Bunout
    ;
    Marcus Petermann
    ;
    M. Bravo
    ;
    Mary M. Kelly
    ;
    S Hirsch
    Glucose intolerance is frequently found in alcoholic patients and an impaired insulin response has been documented in them. To look for alternative mechanisms that could explain this intolerance, a glucose turnover using tritiated glucose and an euglycemic glucose clamp were performed to measure the glucose production rate and peripheral insulin sensitivity, respectively. Two groups of recently abstinent chronic male alcoholic patients without evidence of liver damage were studied. The glucose turnover technique showed a higher basal glucose production rate in alcoholics, compared with normal volunteers (2.83 +/- 0.29 vs. 1.84 +/- 0.22 mg/kg/min); an intravenous ethanol load significantly increased this rate. The euglycemic glucose clamp did not show peripheral insulin resistance in alcoholics, compared with controls.