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Effects of Ethanol on Hepatic Blood Flow in the Rat
Author(s)
H Iturriaga
University of Toronto
Daniel Bunout
University of Toronto
Margarita Petermanri
University of Toronto
University of Toronto
Yedi Israel
University of Toronto
Date Issued
1 de marzo de 1981
Type
Article
Volume
5
Issue
2
Series/Report No.
Alcoholism Clinical and Experimental Research
Start Page
221
End Page
224
ISSN
0145-6008
1530-0277
Abstract
Hepatic blood flow measured by indocyanine green clearance was studied in rats after an acute intoxicating dose of ethanol (2 g/kg) or after chronic ethanol administration by feeding with alcohol liquid diets. Acute intoxication to normal animals did not modify hepatic blood flow. In chronically alcohol-fed rats, hepatic blood flow was significantly decreased when measured after 15 hr of abstinence. If ethanol was not withdrawn and an acute dose of ethanol was given before the indocyanine green clearance, a decreased hepatic blood flow was not observed. It is suggested that the reduction of hepatic blood flow in recently abstinent chronically alcohol-treated animals is related to the withdrawal syndrome.
Keywords