Alave Rosas, Jorge Luis

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Alave Rosas, Jorge Luis
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2013 - 2019142020 - 202647

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    Atypical presentation of Lyme disease in a returning traveler: a case report
    (2025-11-11)
    Salcedo, Andrea S.
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    Carreras, Xosse
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    Saavedra, Joe
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    Saldaña, Sandy
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    Diaz Reyes, Nelson Fidel  
    Lyme disease, caused by Borrelia burgdorferi and transmitted by Ixodes ticks, is rare in South America and is often misdiagnosed in returning travelers. We report the case of a 19-year-old Peruvian male who presented with pruritic erythematous maculopapular lesions and abdominal pain after travel to Maryland, United State of America. His atypical cutaneous findings, including a crusted lesion with ill-defined borders and a maculopapular rash, were initially misinterpreted as bacterial cellulitis, resulting in multiple unsuccessful courses of antibiotics. Further evaluation, guided by his travel history, led to the diagnosis of Lyme disease through serological testing and histopathology. Treatment with doxycycline achieved complete resolution. This case illustrates the diagnostic challenges posed by atypical presentations of Lyme disease in nonendemic regions. Greater awareness among clinicians in South America is essential to recognize imported cases, facilitate early diagnosis, and prevent complications associated with delayed treatment.
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    Assessing the perceptions and factors associated with uptake of monovalent XBB.1.5 BNT162b2 COVID-19 vaccine among healthcare workers: A cross-sectional study in Peru
    (2025-12-19)
    Gonzales-Zamora, Jose A.
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    Araoz-Salinas, Julieta M.
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    Quispe-Vicuña, Carlos
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    Reategui-Garcia, Martín E.
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    Ortiz-Saavedra, Brando
    Objectives: The implementation of the updated monovalent vaccine for the high-risk population in Peru, such as healthcare workers (HW’s), has occurred without an adequate communication campaign by the central government, which has raised many doubts about its efficacy and safety. This study aimed to investigate the perceptions and factors associated with uptake of monovalent XBB.1.5 BNT162b2 COVID-19 vaccine among HW’s in Peru. Methods: We conducted a cross-sectional study based on an online survey from March 22 to May 1, 2024. HW’s (physicians, nurses, etc.) living and practicing in Peru were included. We calculated crude and adjusted prevalence ratios with 95% confidence intervals to determine the associated factors and perceptions using Poisson regression with robust variance. Results: We included 393 HW’s, predominantly women (55.2%) and physicians (63.9%), almost half at 30-49 years of age (50.9%). The majority (72.8%) reported not having been vaccinated with the updated vaccine, but 65% of them intended to do it. Regarding perceptions, more than 70% of respondents thought the updated vaccine was necessary and protective against severe COVID-19 and mortality, but only 16.5% believed it caused severe adverse events. Only 24.7% felt the Peruvian Ministry of Health was adequately informing about the vaccines. In the adjusted multivariate analysis, the uptake of this vaccine was significantly higher among those who lived in the northern macroregion (aPR: 1.96; 95% CI: 1.15 - 3.34), had received six or more vaccine doses (aPR: 2.18; 95% CI: 1.06 - 4.51), were previously hospitalized due to COVID-19 (aPR: 2.18; 95% CI: 1.37 - 3.49), in those who received the bivalent vaccine (aPR: 1.88; 95% CI: 1.17 – 3.04), and in participants who believed that the monovalent updated vaccine should be mandatory for healthcare workers (aPR: 1.76; 95% CI: 1.08 - 2.86). The uptake was lower in those who believed that the monovalent vaccine should not be mandatory (aPR: 0.39; 95% CI: 0.17 - 0.92) and in participants who felt that the Ministry of Health was not adequately informing about the vaccines (aPR: 0.63; 95% CI: 0.40 - 0.97). Conclusions: The present study showed that uptake of the XBB.1.5 vaccine was low among HW’s in Peru. Living in the northern macroregion, previous hospitalization due to COVID-19, and having received six or more vaccine doses were identified as the main factors associated with higher uptake. Our findings underscore the importance of targeted interventions and effective communication strategies to improve vaccination against COVID-19 among HW’s.
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    Cardiac hydatidosis mimicking ischemic heart disease: A case report
    (2026-01-01)
    Chaponan-Lavalle, Andres
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    Quiroz Cortegana, Cherie
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    Gordillo Velasquez, Luis Ivan
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    Caceres Pizarro, Jaime
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    Diaz Reyes, Nelson Fidel  
    , is a zoonotic disease with cardiac involvement reported in less than 2 % of cases but associated with significant clinical challenges. We describe a 44-year-old woman from Peru who presented with exertional chest pain and T-wave inversions on electrocardiography. Imaging revealed a large multiloculated cystic mass with peripheral calcifications in the left ventricular wall, and Western Blot serology confirmed CE. The patient underwent surgical excision under cardiopulmonary bypass, followed by albendazole therapy. Histopathology confirmed a non-viable hydatid cyst. Postoperative recovery was uneventful, and she remained asymptomatic at 16-month follow-up. This case underscores the importance of considering cardiac hydatidosis in endemic regions when evaluating patients with angina-like symptoms in the presence of a cystic cardiac mass on imaging. Public awareness, improved medical education, and ongoing research are crucial to better managing this condition.
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    Level of Knowledge regarding Monkeypox among Peruvian Physicians during the 2022 Outbreak: A Cross-Sectional Study
    (2022-10-12)
    Gonzales-Zamora, Jose
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    Soriano‐Moreno, David R.
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    Soriano Moreno, Anderson Nelver Elías  
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    Ponce-Rosas, Linda
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    Sangster-Carrasco, Lucero
    Introduction: Monkeypox has become a public health emergency given the rapid spread of the disease worldwide. Due to the high incidence of this disease in Peru and the poor knowledge about monkeypox among healthcare workers in non-endemic countries, it is crucial to determine the knowledge status of Peruvian physicians. Methodology: We conducted an analytical cross-sectional study based on an online survey from August to September 2022. Physicians who had a medical license and lived and practiced Medicine in Peru were included. To evaluate the factors associated with a higher level of knowledge, we used crude (cPR) and adjusted (aPR) prevalence ratios with 95% confidence intervals (95% CI) using Poisson regression. Results We included 463 physicians. The mean age was 36.6 (SD: 10.3) years, and most were male (58.1%). Regarding knowledge, the median knowledge score was 14 [IQR: 13 to 15] out of 17 points. In terms of knowledge gaps, only 60.7% of the participants knew that there was an FDA-approved vaccine for monkeypox, 49.0% of participants knew about monkeypox proctitis and 33.3% acknowledged that it could be transmitted by the bite of an infected rodent. We found that taking care of patients with monkeypox (aPR: 1.39; 95% CI: 1.13 to 1.72) was associated with a higher knowledge (> p50) while living in the jungle (aPR: 0.61; 95% CI: 0.41 to 0.91) was associated with lower knowledge (< p50). Conclusions Our study showed a high level of knowledge about monkeypox among Peruvian physicians. However, educational campaigns may be necessary, especially for physicians from the jungle and those who do not have clinical experience in monkeypox.
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    Percepciones e intención de los padres de vacunar a sus hijos bajo 12 años de edad contra la COVID-19: estudio transversal en Perú
    (2022-06-01)
    Gonzales-Zamora, José A.
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    Soriano‐Moreno, David R.
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    Soriano Moreno, Anderson Nelver Elías  
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    Ponce-Rosas, Linda
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    De-Los-Rios-Pinto, Abraham
    BACKGROUND: Despite the proven efficacy and safety of COVID-19 vaccines, pediatric vaccination coverage remains low in many countries. There are still doubts and fears in parents about vaccination in their children under 12 years of age. AIM: To evaluate the perceptions and intention of parents to vaccinate their children under 12 years of age. METHODS: Analytical cross-sectional study based on an online survey that evaluated the parents' perceptions regarding the risk of COVID-19 infection, the need for a vaccine, and the vaccine adverse events in their children under 12 years. We assessed the factors associated with the intention to vaccinate through crude (cPR) and adjusted prevalence rates (aPR), with confidence interval of 95% (CI 95%). RESULTS: 83.5% of respondents had the intention to vaccinate their children under 12 years of age. In the multivariate analysis, the factors associated with a decrease in the intention to vaccinate were to believe that the vaccine was not necessary (aPR 0.65; 95% CI 0.44 - 0.94), that it would not protect (aPR: 0.14; 95% CI 0.03 - 0.63), it would not be safe (aPR: 0.80; 95% CI 0.70 - 0.92) and it would cause long-term side effects (aPR: 0.92; 95% CI 0.85 - 1.00). On the other hand, living on the highlands or jungle was associated with an increase in the intention. CONCLUSION: In Peru, 16.5% of parents would not vaccinate their children under 12 years of age, because they perceived that the vaccine was not necessary and would not protect against COVID-19. In addition, they expressed concerns about the development of possible adverse events.
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    8th IAS Conference on HIV Pathogenesis, Treatment & Prevention 19-22 July 2015, Vancouver, Canada
    (2015-07-01)
    Pate, KM  
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    Pohlmeyer, C
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    Walker-Sperling, V
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    Foote, J
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    Najarro, K
    Author(s): Pate, Kelly Metcalf; Pohlmeyer, Chris; Walker‐Sperling, Victoria; Foote, Jeremy; Najarro, Kevin; Cryer, Catherine; Salgado, Maria; Gama, Lucio; Engle, Elizabeth; Shirk, Erin; Queen, Suzanne; Chioma, Stanley; Vermillion, Meghan; Bullock, Brandon; Li, Ming; Lyons, Claire; Adams, Robert; Zink, Chris; Clements, Janice; Mankowski, Joseph; Blankson, Joel; Micci, Luca; Ryan, Emily; Fromentin, Rémi; Benne, Clarisse; Chomont, Nicolas; Lifson, Jeffrey; Paiardini, Mirko; Lee, Sulggi; Chomont, Nicolas; Fromentin, Remi; Silicano, Robert; Silicano, Janet; Richman, Douglas; O'Doherty, Una; Palmer, Sarah; Burbelo, Peter; Deeks, Steven; Ghneim, Khader; Ahlers, Jeff; Fourati, Slim; Shive, Carey; Cameron, Mark; Mukerjee, Pranab; Ghannoum, Mahmoud; Rodriguez, Benigno; Deeks, Steven; Lederman, Michael; Sekaly, Rafick; Frange, Pierre; Faye, Albert; Avettand‐Fenoel, Veronique; Bellaton, Erainna; Deschamps, Diane; Angin, Mathieu; Caillat‐Zucman, Sophie; Peytavin, Gilles; Le Chenadec, Jerome; Warszawski, Josiane; Rouzioux, Christine; Saez‐Cirion, Asier; Cohort, ANRS Epf‐Co10 Pediatric; Chang, Christina; Cameron, Paul; Elliott, Julian; Perelson, Alan; Roche, Michael; Dantanarayana, Ashanti; Solomon, Ajantha; Naranbhai, Vivek; Tenakoon, Surekha; Hoh, Rebecca; McMahon, James; Sikaris, Ken; Hartogensis, Wendy; Bacchetti, Peter; Hecht, Frederick; Lifson, Jeffrey; Deeks, Steve; Lewin, Sharon; Byrareddy, Siddappa; Arthos, James; Cicala, Claudia; Reimann, Keith; Parslow, Tristram
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    HIV & Hepatitis in the Americas 28–30 April 2016, Mexico City, Mexico
    (2016-04-28)
    Alave Rosas, Jorge Luis  
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    Mayer, Kenneth
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    Sued, Omar
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    Sosa, Néstor
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    Diaz, Ricardo Sobhie
    and creative negotiations. Eradication is possible. It is up to us to make it so.
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    Percepciones e intención de los padres de vacunar a sus hijos menores de 12 años contra la COVID-19: Estudio transversal en Perú
    (2022-01-11)
    Gonzales Zamora, Jose
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    Soriano Moreno, David  
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    Soriano Moreno, Anderson Nelver Elías  
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    Ponce-Rosas, Linda
    ;
    De-Los-Ríos-Pinto, Abraham
    Objetivos: Evaluar las percepciones e intención de los padres de vacunar a sus hijos menores de 12 años en Perú. Metodología: Estudio transversal analítico a partir de una encuesta en línea (25 de noviembre al 6 de diciembre del 2021) para padres de niños menores de 12 años que recopiló la percepción sobre el riesgo de contagio por COVID-19 en sus hijos, sobre la necesidad de vacunación y sobre los eventos adversos relacionados con la vacuna. Evaluamos los factores asociados a la intención de vacunación mediante razones de prevalencia crudas (RPc) y ajustadas (RPa) con intervalos de confianza al 95% (IC 95%). Resultados: El 83.5% de los padres tenían la intención de vacunar a sus hijos menores de 12 años. En el análisis multivariado, los factores asociados a una disminución de la intención de vacunación fueron pensar que la vacuna no es necesaria (RPa: 0.65; IC 95% 0.44 – 0,94), que no protegería (RPa: 0.14; IC 95% 0.03 – 0.63), que no sería segura (RPa: 0.80; IC 95% 0.70 – 0.92) y que ocasionaría efectos negativos a largo plazo (RPa: 0.92; IC 95% 0.85 – 1.00). Por otro lado, residir en la Selva (RPa: 1.09; IC 95%: 1.03 – 1.15) o en la Sierra (RPa: 1.06; IC 95%: 1.00 – 1.11) se asoció a una mayor prevalencia de intención. Conclusiones: En Perú, un 16.5% de padres no vacunaría a sus hijos menores de 12 años, ya que perciben que la vacuna no es necesaria y no protegería contra la COVID-19, además de tener la preocupación de posibles eventos adversos.
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    Perceptions and Intention to Get Vaccinated against Mpox among the LGBTIQ+ Community during the 2022 Outbreak: A Cross-Sectional Study in Peru
    (2023-05-21)
    Araoz-Salinas, Julieta M.
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    Ortiz-Saavedra, Brando
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    Ponce-Rosas, Linda
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    Soriano‐Moreno, David R.
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    Soriano Moreno, Anderson Nelver Elías  
    Vaccination against mpox can control the outbreak by targeting high-risk groups such as the LGBTIQ+ community. The aim of the study was to evaluate the perceptions and intentions to get vaccinated against mpox among the LGBTIQ+ community in Peru. We conducted a cross-sectional study from 1 November 2022 to 17 January 2023 in Peru. We included individuals over 18 years old, belonging to the LGBTIQ+ community, and residing in the departments of Lima and Callao. To evaluate the factors associated with the intention to be vaccinated, we used Poisson regression with robust variance to create a multivariate model. The study comprised 373 individuals who self-identified as members of the LGBTIQ+ community. The participants had a mean age of 31 years (SD ± 9), with 85.0% males and 75.3% reporting to be homosexual men. The majority (88.5%) expressed their intention to receive the vaccine against mpox. Believing that the vaccine is safe was associated with a higher intention to be vaccinated (aPR: 1.24; 95% CI: 1.02 to 1.50; p = 0.028). Our study population showed a high level of mpox vaccination intent. Educational campaigns reinforcing the concept of vaccine safety should be conducted to increase the intention and possibly the vaccination rate in the LGBTIQ+ community.
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