Alave Rosas, Jorge Luis

Cargando...
Miniatura
Nombre preferido
Alave Rosas, Jorge Luis
Afiliación principal
ORCID
ID de autor de Scopus

Filtros

2013 - 2019142020 - 202647

Ajustes

Mostrando 1 - 10 de 61
  • Publicacion
    Algunas métricas están bloqueadas por su 
    configuración de consentimiento
    Item type:Publicación,
    P-997. Successful Implementation of an Infectious Disease-Led Non-Restrictive Antimicrobial Stewardship Program in a Peruvian Hospital
    (2026-01-01)
    Carreras, Xosse
    ;
    Sofia Salcedo, Andrea
    ;
    Muñoz, Sara
    ;
    Diaz Reyes, Nelson Fidel  
    ;
    Salinas, Jorge
    Abstract Background Peru reports high carbapenem and vancomycin usage with concerning resistance rates, including 60.6% third-generation cephalosporin resistance in E.coli bloodstream infections. National legislation requires antimicrobial stewardship programs (ASPs) in secondary and tertiary facilities. Methods We implemented an infectious disease physician-led ASP at a 107-bed Peruvian hospital and report 12-month outcomes. Implementation phases included education and guideline development, prospective audit and feedback without restrictions, and data collection. The ASP targeted meropenem, vancomycin, and linezolid in medicine and ICU wards. Medical students conducted chart reviews with recommendations communicated to physicians. Results We audited 191 records of predominantly elderly patients (median 78 years), with meropenem most prescribed (89.4%). Guideline adherence was 84.7%. Common recommendations included limiting duration (39.2%), adjusting based on cultures (31.7%), and de-escalation (18.5%)(Table1). Implementation rate was 78.8%. In medicine, consumption decreased during intervention: meropenem by 57.1% (10.5 to 4.5 DDD/100 patient-days), vancomycin by 76.7% (1.8 to 0.42), and linezolid by 50% (1.0 to 0.5)(Figure1). In ICU, reductions were 48.6% for meropenem, 50% for vancomycin, with continued post-intervention decreases(Figure2). Challenges included physician resistance, risk-averse prescribing, and suboptimal diagnostics. Conclusion ASPs can be effectively implemented in resource-limited settings through leadership, education, and non-restrictive approaches. Success factors included collaborative methods, multimodal communication, continuous education, and transparent reporting. The post-prescription audit and feedback model maintained physician autonomy while reducing broad-spectrum antibiotic use. Disclosures All Authors: No reported disclosures
    Citas (OpenAlex): 0metric-badges.view 1
  • Publicacion
    Algunas métricas están bloqueadas por su 
    configuración de consentimiento
    Item type:Publicación,
    Citas (OpenAlex): 0metric-badges.view 5
  • Publicacion
    Algunas métricas están bloqueadas por su 
    configuración de consentimiento
    Item type:Publicación,
    Percepciones e intención de los padres de vacunar a sus hijos menores de 12 años contra la COVID-19: Estudio transversal en Perú
    (2022-01-11)
    Gonzales Zamora, Jose
    ;
    Soriano Moreno, David  
    ;
    Soriano Moreno, Anderson Nelver Elías  
    ;
    Ponce-Rosas, Linda
    ;
    De-Los-Ríos-Pinto, Abraham
    Objetivos: Evaluar las percepciones e intención de los padres de vacunar a sus hijos menores de 12 años en Perú. Metodología: Estudio transversal analítico a partir de una encuesta en línea (25 de noviembre al 6 de diciembre del 2021) para padres de niños menores de 12 años que recopiló la percepción sobre el riesgo de contagio por COVID-19 en sus hijos, sobre la necesidad de vacunación y sobre los eventos adversos relacionados con la vacuna. Evaluamos los factores asociados a la intención de vacunación mediante razones de prevalencia crudas (RPc) y ajustadas (RPa) con intervalos de confianza al 95% (IC 95%). Resultados: El 83.5% de los padres tenían la intención de vacunar a sus hijos menores de 12 años. En el análisis multivariado, los factores asociados a una disminución de la intención de vacunación fueron pensar que la vacuna no es necesaria (RPa: 0.65; IC 95% 0.44 – 0,94), que no protegería (RPa: 0.14; IC 95% 0.03 – 0.63), que no sería segura (RPa: 0.80; IC 95% 0.70 – 0.92) y que ocasionaría efectos negativos a largo plazo (RPa: 0.92; IC 95% 0.85 – 1.00). Por otro lado, residir en la Selva (RPa: 1.09; IC 95%: 1.03 – 1.15) o en la Sierra (RPa: 1.06; IC 95%: 1.00 – 1.11) se asoció a una mayor prevalencia de intención. Conclusiones: En Perú, un 16.5% de padres no vacunaría a sus hijos menores de 12 años, ya que perciben que la vacuna no es necesaria y no protegería contra la COVID-19, además de tener la preocupación de posibles eventos adversos.
    Citas (OpenAlex): 0metric-badges.view 5
  • Publicacion
    Algunas métricas están bloqueadas por su 
    configuración de consentimiento
    Item type:Publicación,
    Caracterización epidemiológica, clínica y de laboratorio de esporotricosis en pacientes de un hospital de tercer nivel en Lima-Perú, entre los años 1991 y 2014
    (2016-06-01)
    James A Oyarce
    ;
    Coralith García
    ;
    Jorge Alave  
    ;
    Beatriz Bustamante
    BACKGROUND: Sporothricosis is endemic in numerous Latin American countries and the rest of the world. In Peru is concentrated in regions with warm and humid climate being little known in the rest of the country. AIM: To describe the epidemiological, clinical and laboratory characteristics of patients diagnosed of sporotrichosis in a tertiary-care level hospital in Lima, Peru from 1991 to 2014. METHODS: This was a retrospective, case series. RESULTS: Ninety four patients were involved; most of them were male adults. This condition was acquired more frequently in Cajamarca, Apurímac, and Amazonas. Fixed and lymphocutaneous form were the most frequent forms of presentation in adults and were mostly distributed in upper limbs. Lesions located in head and neck were most frequent in children. Comorbidities were present in 15% of patients and were more frequent in those who presented disseminated cutaneous form. Seventy eight percent of cultures from skin lesions were positive within 7 days. The time to positivity of cultures was longer if the sample came from skin biopsies than skin scraping or skin aspiration. CONCLUSIONS: Most cases of sporotrichosis were acquired in areas of extreme poverty in Peru. The clinical, epidemiological and laboratory findings were similar to those reported elsewhere. The time to positivity of cultures varies based on the type of skin sample. This finding needs to be further evaluated in studies with an increased number of cases.
    Citas (OpenAlex): 16
  • Publicacion
    Algunas métricas están bloqueadas por su 
    configuración de consentimiento
    Item type:Publicación,
    Effects of antituberculosis treatment on pregnancy outcomes in infertile women with genital tuberculosis: a systematic review
    (2023-09-01)
    Flores-Lovon, Kevin
    ;
    Soriano‐Moreno, David R.
    ;
    Medina Ramirez, Sebastian Andre  
    ;
    Fernandez‐Guzman, Daniel
    ;
    Caira‐Chuquineyra, Brenda
    OBJECTIVES: To evaluate the efficacy of antituberculosis therapy on pregnancy outcomes in infertile women with genital tuberculosis. DESIGN: Systematic review. DATA SOURCES: We searched in PubMed/MEDLINE, CENTRAL and EMBASE up to 15 January 2023. Additionally, we manually search the reference lists of included studies. ELIGIBILITY CRITERIA: We included randomised controlled trials (RCT), non-RCTs (non-RCT) and cohort studies that evaluated the effects of antituberculosis treatment on pregnancy outcomes in infertile women with genital tuberculosis compared with not receiving antituberculosis treatment or receiving the treatment for a shorter period. DATA EXTRACTION AND SYNTHESIS: Two independent reviewers extracted data. We used Cochrane Risk of Bias 1.0 and Risk Of Bias In Non-randomised Studies tools for risk of bias assessment and meta-analysis was not performed. We used Grading of Recommendations, Assessment, Development and Evaluations approach to assess the certainty of the evidence. RESULTS: Two RCTs and one non-RCT were included. The antituberculosis regimens were based on isoniazid, rifampicin, pyrazinamide and ethambutol for 6-12 months. In women without structural damage, very low certainty of evidence from one RCT showed that the antituberculosis treatment may have little to no effect on pregnancy, full-term pregnancy, abortion or intrauterine death and ectopic pregnancy, but the evidence is very uncertain. In women with structural damage, very low certainty of evidence from one non-RCT showed that the antituberculosis treatment may reduce the pregnancy rate (297 fewer per 1000, 95% CI -416 to -101), but the evidence is very uncertain. In addition, very low certainty of evidence from one RCT compared a 9-month vs 6-month antituberculosis treatment regimen showed similar effects between the schemes, but the evidence is very uncertain. Two RCTs reported that no adverse events of antituberculosis treatment were noted or were similar in both groups. CONCLUSION: The effect of antituberculosis treatment on pregnancy outcomes in infertile women with genital tuberculosis is very uncertain. PROSPERO REGISTRATION NUMBER: CRD42022273145.
    Citas (OpenAlex): 8metric-badges.view 2
  • Publicacion
    Algunas métricas están bloqueadas por su 
    configuración de consentimiento
    Item type:Publicación,
    metric-badges.view 10
  • Publicacion
    Algunas métricas están bloqueadas por su 
    configuración de consentimiento
    Item type:Publicación,
    The Impact of Digital Technologies on HPV Vaccination Uptake and Intention Among Adolescents, Young Adults and their Parents: a Systematic Review
    (2025-04-20)
    Bancovsky, Daniel
    ;
    Shastry, Manjushree
    ;
    Caccamo, Martina
    ;
    Soares, Rebecca
    ;
    Avellanet, Merce
    Background: Human papillomavirus (HPV) is a preventable sexually transmitted infection and the major risk factor for cervical cancer. The global prevalence of HPV infection is high, especially in low- and mid- income countries (LMIC). HPV immunization has been shown to reduce high-grade cervical cancer lesions and cancer incidence. Despite global HPV vaccination programs initiated in 2006, uptake remains insufficient. Digital media offers a promising avenue to address vaccine hesitancy and improve vaccination rates among adolescents and their parents. Objective: To evaluate the effectiveness of digital media interventions on HPV vaccination rates and intentions. Methods: We undertook a comprehensive search for PubMed, Scopus, Web of Science, Cochrane databases, from inception until May 2024. The review included Randomized Controlled Trials (RCTs) and observational studies focusing on adolescents and young adults (9-26 years) and their parents, and it investigated the impact of digital interventions on vaccination rates and vaccination intention. The quality assessments were assessed using the Cochrane Risk of Bias 2 tool and an adapted Newcastle-Ottawa Scale for RCTs and observational studies respectively, while data extraction focused on study design, demographics, intervention types, and outcomes. Results: From 2350 records, 23 studies (19 RCTs and 4 observational studies) met the inclusion criteria. Digital interventions, including text messages, mobile apps, video content, and web-based platforms, improved HPV vaccination intentions. Narrative-based videos were particularly effective in promoting parents and adolescents’ immunization, especially when the vaccine was offered immediately after the intervention. Nevertheless, barriers such as challenges with access, misconceptions, and socioeconomic factors often hinder translating of intentions into actual uptake. Conclusion: Digital interventions showed great potential in increasing short-term HPV vaccination intentions. Future research should focus on long-term engagements to enhance the effectiveness of digital interventions in promoting HPV immunization uptake. KEYWORDS: Human papillomavirus viruses; Vaccination, Digital Technology, Young adults, Adolescents, Parents;
    Citas (OpenAlex): 0metric-badges.view 1
  • Publicacion
    Algunas métricas están bloqueadas por su 
    configuración de consentimiento
    Item type:Publicación,
    Assessing the perceptions and factors associated with uptake of monovalent XBB.1.5 BNT162b2 COVID-19 vaccine among healthcare workers: A cross-sectional study in Peru
    (2025-12-19)
    Gonzales-Zamora, Jose A.
    ;
    Araoz-Salinas, Julieta M.
    ;
    Quispe-Vicuña, Carlos
    ;
    Reategui-Garcia, Martín E.
    ;
    Ortiz-Saavedra, Brando
    Objectives: The implementation of the updated monovalent vaccine for the high-risk population in Peru, such as healthcare workers (HW’s), has occurred without an adequate communication campaign by the central government, which has raised many doubts about its efficacy and safety. This study aimed to investigate the perceptions and factors associated with uptake of monovalent XBB.1.5 BNT162b2 COVID-19 vaccine among HW’s in Peru. Methods: We conducted a cross-sectional study based on an online survey from March 22 to May 1, 2024. HW’s (physicians, nurses, etc.) living and practicing in Peru were included. We calculated crude and adjusted prevalence ratios with 95% confidence intervals to determine the associated factors and perceptions using Poisson regression with robust variance. Results: We included 393 HW’s, predominantly women (55.2%) and physicians (63.9%), almost half at 30-49 years of age (50.9%). The majority (72.8%) reported not having been vaccinated with the updated vaccine, but 65% of them intended to do it. Regarding perceptions, more than 70% of respondents thought the updated vaccine was necessary and protective against severe COVID-19 and mortality, but only 16.5% believed it caused severe adverse events. Only 24.7% felt the Peruvian Ministry of Health was adequately informing about the vaccines. In the adjusted multivariate analysis, the uptake of this vaccine was significantly higher among those who lived in the northern macroregion (aPR: 1.96; 95% CI: 1.15 - 3.34), had received six or more vaccine doses (aPR: 2.18; 95% CI: 1.06 - 4.51), were previously hospitalized due to COVID-19 (aPR: 2.18; 95% CI: 1.37 - 3.49), in those who received the bivalent vaccine (aPR: 1.88; 95% CI: 1.17 – 3.04), and in participants who believed that the monovalent updated vaccine should be mandatory for healthcare workers (aPR: 1.76; 95% CI: 1.08 - 2.86). The uptake was lower in those who believed that the monovalent vaccine should not be mandatory (aPR: 0.39; 95% CI: 0.17 - 0.92) and in participants who felt that the Ministry of Health was not adequately informing about the vaccines (aPR: 0.63; 95% CI: 0.40 - 0.97). Conclusions: The present study showed that uptake of the XBB.1.5 vaccine was low among HW’s in Peru. Living in the northern macroregion, previous hospitalization due to COVID-19, and having received six or more vaccine doses were identified as the main factors associated with higher uptake. Our findings underscore the importance of targeted interventions and effective communication strategies to improve vaccination against COVID-19 among HW’s.
    Citas (OpenAlex): 0metric-badges.view 3
  • Publicacion
    Algunas métricas están bloqueadas por su 
    configuración de consentimiento
    Item type:Publicación,
    Subcapsular Liver Hematoma: One of the Many Faces of Acute Fascioliasis
    (2024-09-23)
    Jorge Alave  
    ;
    Mey León
    ;
    Angélica Terashima
    ;
    Fátima Concha-Velasco
    ;
    Eduardo Gotuzzo
    Subcapsular liver hematoma is an uncommon and underdiagnosed manifestation of fascioliasis. We report 6 cases and review 21 previous reports. The mean age was 51 years; 12 cases were from Peru; and 18 were women. Only 6 patients required surgical drainage. Medical management is the mainstay treatment.
    Citas (OpenAlex): 6metric-badges.view 3
  • Publicacion
    Algunas métricas están bloqueadas por su 
    configuración de consentimiento
    Item type:Publicación,
    HIV & Hepatitis in the Americas 28–30 April 2016, Mexico City, Mexico
    (2016-04-28)
    Alave Rosas, Jorge Luis  
    ;
    Mayer, Kenneth
    ;
    Sued, Omar
    ;
    Sosa, Néstor
    ;
    Diaz, Ricardo Sobhie
    and creative negotiations. Eradication is possible. It is up to us to make it so.
    Citas (OpenAlex): 0metric-badges.view 6