Vizcarra Ugarte, German Alex

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Vizcarra Ugarte, German Alex
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    Glucose tolerance and the insulin response in recently drinking alcoholic patients: Possible effects of withdrawal
    (1986-03-01)
    H Iturriaga
    ;
    Melani R. Kelly
    ;
    Daniel Bunout
    ;
    María Eugenia Pino
    ;
    T Pereda
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    [SURGICAL ASPECTS OF PANCREATITIS].
    (1963-10-01)
    Dos Santos, Miguel Nuno Lages Coelho
    ;
    Hermosilla, F
    ;
    Fernández‐Gutiérrez, Mar
    ;
    Vh, Oñate
    ;
    Vizcarra Ugarte, German Alex  
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    [Prediction of histological liver damage in asymptomatic alcoholic patients by means of clinical and laboratory data].
    (1993-04-01)
    Iturriaga, H
    ;
    Hirsch, Steffen
    ;
    Bunout, Daniel
    ;
    Díaz, Miguel Ángel
    ;
    Kelly, Matt
    Looking for a noninvasive method to predict liver histologic alterations in alcoholic patients without clinical signs of liver failure, we studied 187 chronic alcoholics recently abstinent, divided in 2 series. In the model series (n = 94) several clinical variables and results of common laboratory tests were confronted to the findings of liver biopsies. These were classified in 3 groups: 1. Normal liver; 2. Moderate alterations; 3. Marked alterations, including alcoholic hepatitis and cirrhosis. Multivariate methods used were logistic regression analysis and a classification and regression tree (CART). Both methods entered gamma-glutamyltransferase (GGT), aspartate-aminotransferase (AST), weight and age as significant and independent variables. Univariate analysis with GGT and AST at different cutoffs were also performed. To predict the presence of any kind of damage (Groups 2 and 3), CART and AST > 30 IU showed the higher sensitivity, specificity and correct prediction, both in the model and validation series. For prediction of marked liver damage, a score based on logistic regression and GGT > 110 IU had the higher efficiencies. It is concluded that GGT and AST are good markers of alcoholic liver damage and that, using sample cutoffs, histologic diagnosis can be correctly predicted in 80% of recently abstinent asymptomatic alcoholics.
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    Atypical alcohol dehydrogenase in Chilean alcohol addicts with and without hepatic damage.
    (1970-09-01)
    Vizcarra Ugarte, German Alex  
    ;
    Pino, María Eugenia
    ;
    Altschiller, H
    ;
    Pereda, T
    Among 80 alcoholics in Chile, 43% had normal ADH, 43% atypical ADH and 14% evidently both enzyme types. The pattern of alcoholismic drinking was not related to enzyme type, but the atypical ADH was...
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    [Effect of ethanol adminstration in the consumption of proteins and nitrogen balance in normal subjects with normoprotein diet].
    (1978-09-15)
    Vizcarra Ugarte, German Alex  
    ;
    Cheng, Anle
    ;
    Villa Gomez, Alejandro
    ;
    Ségure, T
    The effect of excessive alcohol intake on the protein requirements and metabolism in normal subjects has not been clearly determined. In this study we measured the nitrogen balance, the hematrocrit, the hemoglobin, the serum albumin, the cholesterol, and the plasmatic amino acids in 7 non-alcoholic subjects of 25 +/- 5 years of age. A comparison was made of a diet containing 0.8 g of protein per k of weight and 40 Kcal per k of weight administered during 11 days with a period of the same length in which the 1.400 Kcal provided during the control period by carbon hydrates was provided by ethanol (200 g). During the alcoholic period no importants changes were observed in the nitrogen balance, a tendency towards greater positivity being registered. There was a decrease in the serum albumin of 4, 69 +/- 0.31 vs 3, 90 +/- 0,32 g/100 ml and an increase in globulin 1,74 +/- 0,70 vs 2,69 +/- 0,22 g/100 ml. The results showed that in a short period of time the excessive alcohol intake in normal subjects does not increase the protein requirements in spite of a decrease in the serum albumin being observed.
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    Influence of Hyperthyroidism on the Rate of Ethanol Metabolism in Man
    (1978-01-01)
    G Ugarte  
    ;
    Tamara Peresa
    The rate of ethanol metabolism was studied in 3 hyperthyroidism patients without therapy and in 2 after 1 week of treatment with propylthiouracil and reserpine. The rate of ethanol metabolism (mg/kg/h +/- SEM) was 386 +/- 57 in the 3 hyperthyroid patients, 184.5 +/- 2.5 in the 2 treated patients and 159 +/- 15 in 12 euthyroid non-alcoholic subjects. The results suggest that hyperthyroidism markedly increases ethanol metabolism.
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    [Serum levels of thyroid hormones in alcoholic subjects without hepatic insufficiency].
    (1985-08-01)
    Bunout, Daniel
    ;
    Ñañez Del Pino, Daniel
    ;
    Iturriaga, H
    ;
    Barrera, R
    ;
    Perez, Carlos A.
    Etude faite chez des sujets qui viennent recemment de s'arreter de boire. On note une correlation negative entre le metabolisme de l'ethanol et les taux de triiodothyronine. Les mecanismes qui produisent ces resultats ne sont pas clairs mais plusieurs hypotheses sont avancees
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    Protein turnover in abstinent and non-abstinent patients with alcoholic cirrhosis.
    (1995-02-01)
    Sandra Hirsch
    ;
    María Pía de la Maza
    ;
    Marcus Petermann
    ;
    H Iturriaga
    ;
    G Ugarte  
    OBJECTIVE: This study was designed to measure the effect of chronic alcohol intake on leucine turnover in outpatients with stable alcoholic liver cirrhosis. METHODS: Protein turnover rate was measured using L [1-14C] leucine in ten outpatients with proven alcoholic cirrhosis and in five healthy controls. After the performance of the turnover, the patients were divided in two groups depending on the evidence of alcohol ingestion in the previous month. RESULTS: Non-abstinent patients had a significantly higher leucine flux and non-oxidative disposal (73.8 +/- 25.4 and 65.9 +/- 21.6) than abstinent cirrhotic patients (48.9 +/- 9.5 and 43.7 +/- 9.0) and normal controls 37.3 +/- 8.9 and 31.1 +/- 7.6 mumol/m2/min (p < 0.01). Leucine oxidation and serum leucine levels were similar in the three groups. CONCLUSION: Alcohol intake in alcoholic cirrhotic patients has a catabolic effect that could be associated with the nutritional imbalances observed in alcoholic liver disease.
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