Vizcarra Ugarte, German Alex

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Publicacion
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[Prediction of histological liver damage in asymptomatic alcoholic patients by means of clinical and laboratory data].
(1993-04-01)
H Iturriaga
;
Steffen Hirsch
;
Daniel Bunout
;
Miguel Ángel Díaz
;
Matt Kelly
Looking for a noninvasive method to predict liver histologic alterations in alcoholic patients without clinical signs of liver failure, we studied 187 chronic alcoholics recently abstinent, divided in 2 series. In the model series (n = 94) several clinical variables and results of common laboratory tests were confronted to the findings of liver biopsies. These were classified in 3 groups: 1. Normal liver; 2. Moderate alterations; 3. Marked alterations, including alcoholic hepatitis and cirrhosis. Multivariate methods used were logistic regression analysis and a classification and regression tree (CART). Both methods entered gamma-glutamyltransferase (GGT), aspartate-aminotransferase (AST), weight and age as significant and independent variables. Univariate analysis with GGT and AST at different cutoffs were also performed. To predict the presence of any kind of damage (Groups 2 and 3), CART and AST > 30 IU showed the higher sensitivity, specificity and correct prediction, both in the model and validation series. For prediction of marked liver damage, a score based on logistic regression and GGT > 110 IU had the higher efficiencies. It is concluded that GGT and AST are good markers of alcoholic liver damage and that, using sample cutoffs, histologic diagnosis can be correctly predicted in 80% of recently abstinent asymptomatic alcoholics.
Citas (OpenAlex): 3
Publicacion
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[PSYCHOSOMATIC APPROACH TO THE CIRRHOTIC PATIENT].
(1963-10-01)
J Numhauser
;
G Ugarte
Citas (OpenAlex): 0
Publicacion
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[EFFECTS OF TRIDIHEXETYLCLYMEPHENOXALONE ON INDUCED GASTRIC SECRETION WITH THE MAXIMUM HISTAMINE TEST].
(1964-10-01)
G Ugarte
;
H Iturriaga
;
Jorge E. Valenzuela
;
I Inzunza
;
T Cornejo
Citas (OpenAlex): 0metric-badges.view 2
Publicacion
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[Serum enzymes in the diagnosis of hepatic necrosis in alcoholics without hepatic insufficiency].
(1983-10-01)
H Iturriaga
;
D Bunot
;
Pino Me
;
Carla Perez
;
G Ugarte
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Publicacion
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[AUTOIMMUNITY IN THE DISEASE OF THE DIGESTIVE SYSTEM].
(1963-10-01)
G Ugarte
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Publicacion
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[Serum levels of thyroid hormones in alcoholic subjects without hepatic insufficiency].
(1985-08-01)
Daniel Bunout
;
Daniel Ñañez Del Pino
;
H Iturriaga
;
R Barrera
;
Carlos A. Perez
Etude faite chez des sujets qui viennent recemment de s'arreter de boire. On note une correlation negative entre le metabolisme de l'ethanol et les taux de triiodothyronine. Les mecanismes qui produisent ces resultats ne sont pas clairs mais plusieurs hypotheses sont avancees
Citas (OpenAlex): 1
Publicacion
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Experimental hepatic cirrhosis. 1. Morphology and biochemistry of the liver in rats given diets deficient in choline.
(1963-01-01)
H Iturriaga
;
T Pizzi
;
G Ugarte
;
F Lorca
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Publicacion
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[Experimental liver cirrhosis. Transaminase activity, collagen deposit and cell proliferation in the rat with dietetic cirrhosis].
(1967-02-01)
H Iturriaga
;
G Ugarte
;
M Peterman
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Publicacion
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[A clinico-pathological study of the liver damage in alcoholic patients].
(1969-12-01)
I Insunza
;
H Iturriaga
;
G Ugarte
;
H Altschiller
Citas (OpenAlex): 2metric-badges.view 1
Publicacion
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Glucose tolerance and the insulin response in recently drinking alcoholic patients: Possible effects of withdrawal
(1986-03-01)
H Iturriaga
;
Melani R. Kelly
;
Daniel Bunout
;
María Eugenia Pino
;
T Pereda
Citas (OpenAlex): 16

Vizcarra Ugarte, German Alex

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