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The Impact of Digital Technologies on HPV Vaccination Uptake and Intention Among Adolescents, Young Adults and their Parents: a Systematic Review
Author(s)
Bancovsky, Daniel
Edmond and Lily Safra Children's Hospital
Shastry, Manjushree
IQVIA (India)
Caccamo, Martina
Ospedale A. Perrino
Soares, Rebecca
Avellanet, Merce
Coyoy-Say, Magali
Universidad de San Carlos de Guatemala
Oiwoh, Sebastine
Irrua Specialist Teaching Hospital
Chapagain, Kumud
B.P. Koirala Institute of Health Sciences
Montealegre, Ignacio
Peace Corps
Vásquez-Pérez, Omar E.
Sharma, Rintu
Princess Margaret Cancer Centre
Qudayr, Asma
Taif University
Nguyen, Hoang
Dal Bianco, Beatrice
Borborema, Cynthia
Fleury S.A. (Brazil)
Grupo Fleury, São Paulo, São Paulo, Brazil
Kleber, Fabricio
Universidade de Caxias do Sul
Alsatou, Faiez
Klinikum Chemnitz
Duarte, Felipe
Hospital Alemão Oswaldo Cruz
Genc, Ilgin
Cabral, Isabel
Rodriguez, Jessica
Calit, Juliana
Real Hospital Português
Vidoto, Lucas
Real Hospital Português
Viola, Luiz
Real Hospital Português
Antonieta Lopes, Maria
Real Hospital Português
Magalhaes, Maria
Faculdade São Leopoldo Mandic
São Leopoldo Mandic, Campinas, Brazil
Rioja, Patricia
The University of Texas Southwestern Medical Center
Nunez-Rocha, Ricardo E.
The University of Texas Southwestern Medical Center
Huynh, Yoldyz
The University of Texas Southwestern Medical Center
Ramirez, Arantxa
Beth Israel Deaconess Medical Center
Grohmann, Barbara
Faculdade São Leopoldo Mandic
Ramos, Walter
Carvalho, Alessandra
Sarah Network of Rehabilitation Hospitals
Date Issued
20 de abril de 2025
Type
Review
Volume
10
Issue
4
Series/Report No.
Principles and Practice of Clinical Research Journal
ISSN
2378-1890
Abstract
Background: Human papillomavirus (HPV) is a preventable sexually transmitted infection and the major risk factor for cervical cancer. The global prevalence of HPV infection is high, especially in low- and mid- income countries (LMIC). HPV immunization has been shown to reduce high-grade cervical cancer lesions and cancer incidence. Despite global HPV vaccination programs initiated in 2006, uptake remains insufficient. Digital media offers a promising avenue to address vaccine hesitancy and improve vaccination rates among adolescents and their parents. Objective: To evaluate the effectiveness of digital media interventions on HPV vaccination rates and intentions. Methods: We undertook a comprehensive search for PubMed, Scopus, Web of Science, Cochrane databases, from inception until May 2024. The review included Randomized Controlled Trials (RCTs) and observational studies focusing on adolescents and young adults (9-26 years) and their parents, and it investigated the impact of digital interventions on vaccination rates and vaccination intention. The quality assessments were assessed using the Cochrane Risk of Bias 2 tool and an adapted Newcastle-Ottawa Scale for RCTs and observational studies respectively, while data extraction focused on study design, demographics, intervention types, and outcomes. Results: From 2350 records, 23 studies (19 RCTs and 4 observational studies) met the inclusion criteria. Digital interventions, including text messages, mobile apps, video content, and web-based platforms, improved HPV vaccination intentions. Narrative-based videos were particularly effective in promoting parents and adolescents’ immunization, especially when the vaccine was offered immediately after the intervention. Nevertheless, barriers such as challenges with access, misconceptions, and socioeconomic factors often hinder translating of intentions into actual uptake. Conclusion: Digital interventions showed great potential in increasing short-term HPV vaccination intentions. Future research should focus on long-term engagements to enhance the effectiveness of digital interventions in promoting HPV immunization uptake. KEYWORDS: Human papillomavirus viruses; Vaccination, Digital Technology, Young adults, Adolescents, Parents;