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Evaluación de la toxicidad de chalconas sintéticas con potencial anti-Leishmania en ratones BALB/c
Author(s)
Universidad Peruana Cayetano Heredia
Inés Castro
Universidad Peruana Cayetano Heredia
Carlos Yauri
Universidad Peruana Cayetano Heredia
Valérie Jullian
Pharmacochimie et Biologie pour le Développement
Jorge Arévalo
Universidad Peruana Cayetano Heredia
Michel Sauvain
Pharmacochimie et Biologie pour le Développement
Vanessa Adaui
Universidad Peruana Cayetano Heredia
Denis Castillo
Universidad Peruana Cayetano Heredia
Date Issued
4 de septiembre de 2021
Type
Article
Volume
38
Issue
3
Series/Report No.
Revista Peruana de Medicina Experimental y Salud Pública
Start Page
424
End Page
33
ISSN
1726-4634
1726-4642
Abstract
OBJECTIVE: To evaluate the toxicity of three synthetic chalcones administered intraperitoneally to BALB/c mice. MATERIALS AND METHODS: The median lethal dose (LD50) was estimated by Dixon's Up-and-Down method. Subchronic toxicity of chalcones was evaluated at 20 and 40 mg/kg for 21 days. Behavioral, physiological, biochemical, and histological toxic effects were evaluated. RESULTS: Chalcone 43 produced mucus in feces, visceral damage (liver) and alterations in organ coefficient (kidney, p = 0.037 and brain, p = 0.008) when compared to the control group. In addition, histological analysis showed that this chalcone produced edema, inflammation and necrosis in the evaluated organs, although there was no significant difference with the control. None of the biochemical parameters differed significantly between the treatment groups at 40 mg/kg dose and the control. CONCLUSIONS: The LD50 for all three chalcones was greater than 550 mg/kg of body weight. Chalcones 40 and 42 were found to be relatively non-toxic. Both can be considered safe for intraperitoneal application in BALB/c mice and, consequently, are potential candidates for use in the treatment of leishmaniasis.
Keywords