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Hepatic alcohol dehydrogenase in alcoholic addicts with and without hepatic damage
Author(s)
Date Issued
1 de junio de 1967
Type
Article
Volume
12
Issue
6
Series/Report No.
Digestive Diseases and Sciences
Start Page
589
End Page
592
ISSN
0163-2116
1573-2568
Abstract
Hepatic alcohol dehydrogenase was measured in liver homogenates from normal, moderate drinkers, and from alcoholics with normal livers, steatosis, and liver cirrhosis. Hepatic alcohol-dehydrogenase activity was 0.37±0.12 µM/hr./mg. of protein in the normals, 0.18±0.13 µM/hr/mg. in alcoholics with normal liver histology, 0.12±0.09 µM/hr./mg. in alcoholics with fatty liver, and 0.12±0.08 µM/hr./mg. in patients with alcoholic cirrhosis. Alcohol dehydrogenase was significantly lower among alcoholics. There was no difference in the activity of this enzyme between alcoholic patients with liver damage and those without liver damage.
Keywords