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Possible relationship between the rate of ethanol metabolism and the severity of hepatic damage in chronic alcoholics
Author(s)
Date Issued
1 de mayo de 1977
Type
Article
Volume
22
Issue
5
Series/Report No.
Digestive Diseases and Sciences
Start Page
406
End Page
410
ISSN
0163-2116
1573-2568
Abstract
The rate of ethanol metabolism (EMR) was determined in alcoholic patients with or without hepatic necrosis, steatosis, and/or cirrhosis. Fifty six cases were studied after 9–25 days of abstinence (mean 15 days). A significant increase in EMR (P<0.01) was found in alcoholics with hepatic necrosis (265±20.5 mg/kg/hr) compared with alcoholics with normal liver histology (154±17) and nonalcoholic controls (159±15). In alcoholics with liver steatosis but without necrosis a lesser increase in EMR (207±20,P<0.05) was also observed. Patients with slight fibrosis but without other abnormalities in their liver biopsies and cirrhotics with overt liver failure (jaundice, ascites) showed EMR similar to controls.
Keywords