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The Impact of Digital Technologies on HPV Vaccination Uptake and Intention Among Adolescents, Young Adults and their Parents: a Systematic Review
Author(s)
Daniel Bancovsky
Manjushree Shastry
Martina Caccamo
Rebecca Santos Soares
Merce Avellanet
Magali Coyoy-Say
Sebastine Oiwoh
Kumud Chapagain
Ignacio Montealegre
Omar E. Vásquez-Pérez
Rintu Sharma
Asma Qudayr
Hoàng Bách Nguyễn
Beatrice Dal Bianco
Cynthia L. P. de Borborema
Grupo Fleury, São Paulo, São Paulo, Brazil
Fabricio Kleber
Faiez Alsatou
Felipe Duarte
Ilgin Genc
Isabel Cabral
Jessica Rodriguez
Juliana Calit
Lucas Vidoto
Luiz Viola
Maria Antonieta Lopes
Maria Magalhaes
São Leopoldo Mandic, Campinas, Brazil
Patricia Rioja
Ricardo E. Nunez-Rocha
Y. Wendy Huynh
Arantxa Ramirez
Barbara Grohmann
Walter Enrique Mogrovejo Ramos
Alessandra Carvalho
Date Issued
20 de abril de 2025
Type
Other
Volume
10
Issue
4
Abstract
Background: Human papillomavirus (HPV) is a preventable sexually transmitted infection and the major risk factor for cervical cancer. The global prevalence of HPV infection is high, especially in low- and mid- income countries (LMIC). HPV immunization has been shown to reduce high-grade cervical cancer lesions and cancer incidence. Despite global HPV vaccination programs initiated in 2006, uptake remains insufficient. Digital media offers a promising avenue to address vaccine hesitancy and improve vaccination rates among adolescents and their parents. Objective: To evaluate the effectiveness of digital media interventions on HPV vaccination rates and intentions. Methods: We undertook a comprehensive search for PubMed, Scopus, Web of Science, Cochrane databases, from inception until May 2024. The review included Randomized Controlled Trials (RCTs) and observational studies focusing on adolescents and young adults (9-26 years) and their parents, and it investigated the impact of digital interventions on vaccination rates and vaccination intention. The quality assessments were assessed using the Cochrane Risk of Bias 2 tool and an adapted Newcastle-Ottawa Scale for RCTs and observational studies respectively, while data extraction focused on study design, demographics, intervention types, and outcomes. Results: From 2350 records, 23 studies (19 RCTs and 4 observational studies) met the inclusion criteria. Digital interventions, including text messages, mobile apps, video content, and web-based platforms, improved HPV vaccination intentions. Narrative-based videos were particularly effective in promoting parents and adolescents’ immunization, especially when the vaccine was offered immediately after the intervention. Nevertheless, barriers such as challenges with access, misconceptions, and socioeconomic factors often hinder translating of intentions into actual uptake. Conclusion: Digital interventions showed great potential in increasing short-term HPV vaccination intentions. Future research should focus on long-term engagements to enhance the effectiveness of digital interventions in promoting HPV immunization uptake. KEYWORDS: Human papillomavirus viruses; Vaccination, Digital Technology, Young adults, Adolescents, Parents;