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Long-Term Neuropsychiatric, Neurocognitive, and Functional Outcomes of Patients Receiving ECMO
Author(s)
Johns Hopkins University
Jin Kook Kang
Johns Hopkins University
Shivalika Khanduja
Johns Hopkins University
Arjun K. Menta
Johns Hopkins University
Syed A. Ahmad
Johns Hopkins University
Olivia Liu
Johns Hopkins University
Emily Rodriguez
Johns Hopkins University
Marcus Spann
Johns Hopkins University
Adrían V. Hernández
Johns Hopkins University
Daniel Brodie
Johns Hopkins University
Glenn Whitman
Johns Hopkins University
Sung‐Min Cho
Johns Hopkins University
Date Issued
5 de enero de 2024
Type
Other
Volume
102
Issue
3
Series/Report No.
Neurology
Start Page
e208081
End Page
e208081
ISSN
0028-3878
1526-632X
Abstract
BACKGROUND AND OBJECTIVES: Despite the common occurrence of neurologic complications during extracorporeal membrane oxygenation (ECMO) support, data on long-term neuropsychiatric, neurocognitive, and functional outcomes are sparse. We aimed to determine the prevalence of long-term neuropsychiatric symptoms, neurocognitive and functional impairment, and favorable neurologic outcomes in adult patients who receive ECMO. METHODS: PubMed, Embase, Cochrane, Web of Science, and Scopus were searched for text related to ECMO and neuropsychiatric, neurocognitive, and functional outcomes from inception to May 3, 2023. Our primary outcome was the prevalence of neuropsychiatric symptoms (pain/discomfort, anxiety, depression, posttraumatic stress disorder [PTSD], and sleep disturbance) at long-term (≥6 months) follow-up. Our secondary outcomes were the prevalence of neurocognitive impairment (memory, attention, and reasoning), functional impairment (daily activities, physical activity/mobility, and personal/self-care), and favorable neurologic outcomes (Cerebral Performance Category ≤2, modified Rankin scale ≤3, or Glasgow Outcome Scale ≥4). This study was registered in PROSPERO (CRD42023420565). RESULTS: = 0.68). DISCUSSION: A substantial proportion of ECMO patients seemed to experience neuropsychiatric symptoms and neurocognitive and functional impairments at long-term follow-up. Considerable heterogeneity in methodology for gauging these outcomes exists, warranting the need for standardization. Multicenter prospective observational studies are indicated to further investigate risk factors for these outcomes in ECMO-supported patients.
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