Alvarez Manrique, Victor Daniel

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Alvarez Manrique, Victor Daniel
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2011 - 201932020 - 202621

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  • Publicación
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    Factors associated, symptoms, and treatments of guillain-barré syndrome: a narrative review
    (2025-02-18)
    López-Peña, Emilia
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    Camizán-Julca, Diana
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    Dávila-Pezo, Jonathan
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    Morales-Ruiz, Sayra
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    Alvarez Manrique, Victor Daniel  
    Objective: To conduct a brief literature review on Guillain-Barré Syndrome (GBS), its associated factors, and available treatments. Design: Literature review based on a narrative synthesis.Databases: Scopus, ScienceDirect, SciELO, Google Scholar, and PubMed. Study Selection: Documents were selected through a critical literature review, considering inclusion and exclusion criteria. Results: The literature analysis included a corpus of 15 articles, comprising 2 statistical analyses, 6 narrative reviews, 3 systematic reviews, 2 observational studies, and 2 clinical cases. The studies primarily involved a population of adult men and women, children, and pregnant women, mostly from low-income and vulnerable backgrounds. Patients diagnosed with GBS were associated with COVID-19, Systemic Lupus Erythematosus (SLE), Posterior Reversible Encephalopathy Syndrome (PRES), Zika virus, and dengue. Conclusions: Research related to GBS highlights numerous causes and complications. GBS is significantly associated with muscle weakness, reduced mobility, and conditions such as SLE and PRES. During the COVID-19 pandemic, a slight increase in GBS cases was recorded. Although uncommon, GBS complications can lead to cardiovascular, respiratory, and gastrointestinal issues. Research does not explore in-depth preventive strategies or early management of these complications. There are currently limited treatments available to improve patient outcomes.
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    Post-covid in patients with obesity: a narrative review
    (2025-02-18)
    Vásquez-Granda, Janeth
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    Tarrillo-Olivos, Jessy C.
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    Pereyra-Urbina, Naomy R.
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    Santacruz, Jose F.
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    Cabanillas-Carrero, Yajahira M.
    Objective: This study aims to conduct a brief literature review on post-COVID-19 complications in obese patients.Design: A literature review based on a narrative synthesis.Data Sources: The databases consulted include Science Direct, Scopus, Scielo, Google Scholar, and PubMed.Study Selection: Multiple articles were selected, applying inclusion criteria focused on post-COVID-19 complications in obese patients, with publications ranging from 2020 to 2024. Irrelevant studies were excluded. The final selection included articles from 10 different countries.Data Extraction: From each study, key data were extracted, including research design, population characteristics, and main reported complications. The information was organized narratively to facilitate comparison of findings across studies.Results: Out of 261,357 articles, 15 relevant articles were selected for the review. These articles were published in 10 countries, as follows: Spain (3 middle-income and 1 lower-middle income), Italy (1 lower-middle income, 1 high-income, and 1 mixed-income), India (2 middle and lower income), Russia (1 middle income), Japan (1 high, middle, and low income), Germany (1 middle income), United States (1 middle income), Mexico (1 middle income), Brazil (1 middle income), and China (1 high and middle income). The findings indicate that socioeconomic inequalities tend to increase the risk of COVID-19-related mortality.Conclusion: COVID-19 is associated with type 2 diabetes, an increased risk of coronary problems, hypertension, and nerve damage such as polyneuropathy, affecting muscle strength and increasing the mortality rate in respiratory diseases such as COPD, leading to lung damage and fibrosis. Treatment should be comprehensive, including vaccines, respiratory exercises, and physiotherapy, where the drug Veklury (remdesivir) has shown efficacy in accelerating recovery and strengthening the immune system. Additionally, post-COVID conditions such as anxiety, depression, and persistent respiratory issues should be addressed.
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    Systemic lupus erythematosus: clinical considerations for diagnosis and management
    (2026-01-01)
    Raygada Altamirano, Ariana Nicole
    ;
    Tuanama Vera, Scoly Kinzoo
    ;
    Puelles Davila, Laura Alejandra
    ;
    Sisley Ramírez, Claudia Ximena
    ;
    Dávila Delgado, Gerson Abel
    en pacientes femeninas que consultan por mamoplastia de aumento en un consultorio privado
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    Validation of an Organizational Climate Scale in health workers
    (2024-03-11)
    Flor Damiano-Aulla, Flor Damiano-Aulla
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    Raqui-Rojas, Jeydi
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    Alvarez Manrique, Victor Daniel  
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    Sairitupa Sanchez, Liset Zenaida  
    ;
    Morales Garcia, Wilter Charming  
    Introduction: organizational climate is a key factor in employee performance and satisfaction. In this study, the validity and reliability of an organizational climate scale in agroindustrial companies in Peru was examined. Objective: to analyze the psychometric properties of an organizational climate scale adapted to Peruvian Spanish. Methods: A methodological study was carried out. Demographic data were collected, as well as responses to an organizational climate questionnaire. Results: the data were analyzed using confirmatory factorial analysis (CFA). The reliability of the instrument was high (α = 0,92). However, the factor loadings of several items were not adequate, so a unidimensional model was tested, then a model with adequate factor loadings, and finally an optimal model. In this last 9-item model, the fit was optimal, and the factor loading was adequate for all items. Conclusion: overall, the organizational climate scale demonstrated good reliability and validity in this context of agroindustrial companies in Peru. However, some items needed to be revised to improve the scale's accuracy. These findings provide a valuable tool for measuring the organizational climate in these types of companies and pave the way for future research in this field
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    Novel mutations associated with nephrogenic diabetes insipidus. A clinical-genetic study
    (2015-04-21)
    RenalTube Group  
    ;
    Alejandro García‐Castaño
    ;
    Gustavo Pérez de Nanclares
    ;
    Leire Madariaga
    ;
    Mireia Aguirre
    Molecular diagnosis is a useful diagnostic tool in primary nephrogenic diabetes insipidus (NDI), an inherited disease characterized by renal inability to concentrate urine. The AVPR2 and AQP2 genes were screened for mutations in a cohort of 25 patients with clinical diagnosis of NDI. Patients presented with dehydration, polyuria-polydipsia, failure to thrive (mean ± SD; Z-height −1.9 ± 2.1 and Z-weight −2.4 ± 1.7), severe hypernatremia (mean ± SD; Na 150 ± 10 mEq/L), increased plasma osmolality (mean ± SD; 311 ± 18 mOsm/Kg), but normal glomerular filtration rate. Genetic diagnosis revealed that 24 male patients were hemizygous for 17 different putative disease-causing mutations in the AVPR2 gene (each one in a different family). Of those, nine had not been previously reported, and eight were recurrent. Moreover, we found those same AVPR2 changes in 12 relatives who were heterozygous carriers. Further, in one female patient, AVPR2 gene study turned out to be negative and she was found to be homozygous for the novel AQP2 p.Ala86Val alteration. Conclusion: Genetic analysis presumably confirmed the diagnosis of nephrogenic diabetes insipidus in every patient of the studied cohort. We emphasize that we detected a high presence (50 %) of heterozygous females with clinical NDI symptoms.
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    Embracing Monogenic Parkinson's Disease: The MJFF Global Genetic PD Cohort
    (2023-01-24)
    Eva‐Juliane Vollstedt  
    ;
    Susen Schaake
    ;
    Katja Lohmann
    ;
    Shalini Padmanabhan
    ;
    Alexis Brice
    BACKGROUND: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and availability of clinical data and clinical trial-ready cohorts is limited. OBJECTIVE: The objectives are to (1) establish an international cohort of affected and unaffected individuals with PD-linked variants; (2) provide harmonized and quality-controlled clinical characterization data for each included individual; and (3) further promote collaboration of researchers in the field of monogenic PD. METHODS: We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data. All registered cases underwent thorough quality checks, and pathogenicity scoring of the variants and genotype-phenotype relationships were analyzed. RESULTS: We collected 3888 variant carriers for our analyses, reported by 92 centers (42 countries) worldwide. Of the included individuals, 3185 had a diagnosis of PD (ie, 1306 LRRK2, 115 SNCA, 23 VPS35, 429 PRKN, 75 PINK1, 13 DJ-1, and 1224 GBA) and 703 were unaffected (ie, 328 LRRK2, 32 SNCA, 3 VPS35, 1 PRKN, 1 PINK1, and 338 GBA). In total, we identified 269 different pathogenic variants; 1322 individuals in our cohort (34%) were indicated as not previously published. CONCLUSIONS: Within the MJFF Global Genetic PD Study Group, we (1) established the largest international cohort of affected and unaffected individuals carrying PD-linked variants; (2) provide harmonized and quality-controlled clinical and genetic data for each included individual; (3) promote collaboration in the field of genetic PD with a view toward clinical and genetic stratification of patients for gene-targeted clinical trials. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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    Diabetes and cardiac complications: A narrative review
    (2026-01-01)
    Gonzales Ishuiza, Fiorella
    ;
    Gálvez Torres, Juan Manuel
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    Aspajo Isuiza, Tahiz
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    Valqui Delgado, Peggui Zadith
    ;
    Torres Putpaña, Xiomara del Carmen
    Objective: to carry out a narrative review on diabetes and cardiac complications, through risk factors, treatment and etiology.Method: an information search was conducted in Scoopus, PubMed, and Google Scholar.Data selection: Documents were selected and analyzed through a critical literature review, taking into account inclusion and exclusion criteria.Results: a corpus of 23 articles was analyzed, of which 6 correspond to systematic studies, 6 to literary studies, 3 to narrative studies, 2 to cross-sectional studies, 2 to descriptive studies, 2 to quantitative studies, 2 to multicenter studies.The population studied includes older people, pregnant mothers, young people, the elderly.The studies were carried out in various countries, such as the United Kingdom, Japan, Singapore, the United States, Australia, Ghana-United Arab Emirates, Italy, China, Indonesia and Chile.The diagnoses were characterized by 7 articles that addressed diabetes risk factors, 9 to treatment, 8 to etiology.Regarding socioeconomic level, 2 articles mentioned that they were from low-income countries, 12 articles mentioned that they were from upper-middle countries, 6 articles mentioned that they were medium-high countries, and 3 from countries that do not specify their socioeconomic level.Conclusion: Type 2 diabetes is associated with heart failure in women that worsens with coronary artery disease, directly impacting the myocardium with risk of death.The use of SGLT2 inhibitors represents an important therapeutic advance, since it promotes renal glucose elimination, improves metabolic control and reduces heart failure events.Diabetes causes progressive damage to the cardiovascular system, where endothelial dysfunction plays a central role by promoting inflammation and vascular deterioration.The studies, carried out mostly in middle-and high-income countries, show barriers such as misinformation, failures in prevention and inequality in access to diagnosis.The need to improve education and access to health services is highlighted, especially in low-resource contexts, since this affects patients with DM2, T1D, cardiovascular risk, cardiac complications, heart failure and diabetic cardiomyopathy.
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    Establishing an online resource to facilitate global collaboration and inclusion of underrepresented populations: Experience from the MJFF Global Genetic Parkinson’s Disease Project
    (2023-10-03)
    Eva‐Juliane Vollstedt  
    ;
    Harutyun Madoev
    ;
    Anna Aasly
    ;
    Azlina Ahmad‐Annuar
    ;
    Bashayer Al‐Mubarak
    Parkinson's disease (PD) is the fastest-growing neurodegenerative disorder, currently affecting ~7 million people worldwide. PD is clinically and genetically heterogeneous, with at least 10% of all cases explained by a monogenic cause or strong genetic risk factor. However, the vast majority of our present data on monogenic PD is based on the investigation of patients of European White ancestry, leaving a large knowledge gap on monogenic PD in underrepresented populations. Gene-targeted therapies are being developed at a fast pace and have started entering clinical trials. In light of these developments, building a global network of centers working on monogenic PD, fostering collaborative research, and establishing a clinical trial-ready cohort is imperative. Based on a systematic review of the English literature on monogenic PD and a successful team science approach, we have built up a network of 59 sites worldwide and have collected information on the availability of data, biomaterials, and facilities. To enable access to this resource and to foster collaboration across centers, as well as between academia and industry, we have developed an interactive map and online tool allowing for a quick overview of available resources, along with an option to filter for specific items of interest. This initiative is currently being merged with the Global Parkinson's Genetics Program (GP2), which will attract additional centers with a focus on underrepresented sites. This growing resource and tool will facilitate collaborative research and impact the development and testing of new therapies for monogenic and potentially for idiopathic PD patients.
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    Multisystem inflammatory syndrome in children: a narrative review
    (2026-01-01)
    Flores Yumbato, Maisa
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    Pardave Ambicho, Rut
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    Alarcón Herrera, Eliana
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    Gomez Orosco, Alisson
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    Alvarez Manrique, Victor Daniel  
    Objective: to conduct a literature review on multisystem inflammatory syndrome in children, focusing on cardiac involvement, complications, and manifestations.Method: literature review based on narrative synthesis.
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    Hospital-acquired pneumonia: a narrative review
    (2026-01-01)
    Morales Garcia, Wilter Charming  
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    Alvarez Manrique, Victor Daniel  
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    Morales García, Wilter Eyvi Mardel  
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    Vásquez Lomas, Katherin Anais
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    Tangoa Pérez, Susy Caroly
    Objective: to conduct a literature review on hospital-acquired pneumonia through factors, treatment, and prevention.Method: as data sources, Scopus, SciELO, PubMed, Google Scholar were used.Data selection: Documents were selected and analyzed under a critical literature review, considering inclusion and exclusion criteria.Results: a corpus of 19 articles was analyzed, including 6 retrospective studies, 4 systematic reviews, 3 prospective studies, 2 narrative studies, 2 cross-sectional studies, 1 qualitative study, 1 observational study, 1 meta-analysis, one multiple logistic regression analysis, one longitudinal study, one analytical review, one phase III trial, one literature review, and one quantitative study.The population studied included pediatric patients, young people, adults, and the elderly.The studies were conducted in various countries, such as Spain, China, Mexico, Brazil, Canada, the Philippines, the United States, India, Egypt, Peru, France, Romania, Italy, Argentina, Oman, and the Czech Republic, each of which contributed a unique perspective to the research.Two articles addressed neurological factors, 11 focused on manifestations, and 6 dealt with predictive factors.The clinical condition of the patients in the studies, 8 articles analyzed the results of acute ischemic stroke (AIS), severe TBI, craniofacial trauma, moderate TBI, chest trauma, pulmonary contusion, acute diseases, hip fracture, chronic lung disease, periodontal disease, poor oral health, and comorbidities in terms of socioeconomic status.The studies were conducted in countries with diverse resources and incomes, reflecting improved access to effective diagnosis of hospital-acquired pneumonia.Conclusion: NIH and its mortality rate are associated with different factors, with timely diagnosis and appropriate treatment being essential to avoid complications.The collaboration of nursing staff and multidisciplinary collaboration is highlighted to achieve better control and reduce the incidence of nosocomial infections.
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