Alvarez Manrique, Victor Daniel

Preferred name
Alvarez Manrique, Victor Daniel
Main Affiliation
Email
victor.alvarez@upeu.edu.pe
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    Pneumonia and pulmonary fibrosis: a narrative review
    (2026-01-01)
    Cristhian Amir Ramírez Arcentales
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    Jhan Antony Vinces Paredes
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    Bety Consuelo Cordova Cruz
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    Diana Katherine Choquehuanca Guevara
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    Tatiana Vargas Ramírez
    Objective: to briefly review the literature on pneumonia and its incidence in pulmonary fibrosis, considering treatment, prognosis, risk factors, and diagnosis.Design: literature review based on a narrative synthesis.
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    Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results
    (2020-12-02)
    BACKGROUND: World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs - remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a - in patients hospitalized with coronavirus disease 2019 (Covid-19). METHODS: We randomly assigned inpatients with Covid-19 equally between one of the trial drug regimens that was locally available and open control (up to five options, four active and the local standard of care). The intention-to-treat primary analyses examined in-hospital mortality in the four pairwise comparisons of each trial drug and its control (drug available but patient assigned to the same care without that drug). Rate ratios for death were calculated with stratification according to age and status regarding mechanical ventilation at trial entry. RESULTS: At 405 hospitals in 30 countries, 11,330 adults underwent randomization; 2750 were assigned to receive remdesivir, 954 to hydroxychloroquine, 1411 to lopinavir (without interferon), 2063 to interferon (including 651 to interferon plus lopinavir), and 4088 to no trial drug. Adherence was 94 to 96% midway through treatment, with 2 to 6% crossover. In total, 1253 deaths were reported (median day of death, day 8; interquartile range, 4 to 14). The Kaplan-Meier 28-day mortality was 11.8% (39.0% if the patient was already receiving ventilation at randomization and 9.5% otherwise). Death occurred in 301 of 2743 patients receiving remdesivir and in 303 of 2708 receiving its control (rate ratio, 0.95; 95% confidence interval [CI], 0.81 to 1.11; P = 0.50), in 104 of 947 patients receiving hydroxychloroquine and in 84 of 906 receiving its control (rate ratio, 1.19; 95% CI, 0.89 to 1.59; P = 0.23), in 148 of 1399 patients receiving lopinavir and in 146 of 1372 receiving its control (rate ratio, 1.00; 95% CI, 0.79 to 1.25; P = 0.97), and in 243 of 2050 patients receiving interferon and in 216 of 2050 receiving its control (rate ratio, 1.16; 95% CI, 0.96 to 1.39; P = 0.11). No drug definitely reduced mortality, overall or in any subgroup, or reduced initiation of ventilation or hospitalization duration. CONCLUSIONS: These remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19, as indicated by overall mortality, initiation of ventilation, and duration of hospital stay. (Funded by the World Health Organization; ISRCTN Registry number, ISRCTN83971151; ClinicalTrials.gov number, NCT04315948.).
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    Ureterocele urothelial carcinoma: managing a rare presentation
    (2016-02-16)
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    Milagros Abad‐Licham
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    Eloy Silva
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    Victor E. Alvarez
    ;
    Francis Piccone
    It is very uncommon for urothelial carcinoma to develop in an ureterocele. It is generally discovered in an imaging study or in connection with haematuria. We found very few reports in the literature. Here, we report on the case of a 71-year-old male who initially presented with haematuria and low back pain and who then underwent transurethral resection for an intraureterocele tumour. Pathology confirmed urothelial carcinoma.
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    Crohn’s disease: a narrative review
    (2026-01-01)
    Wilter C. Morales García
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    Piero Alexander Vargas Ruiz
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    Bilha Raquel Pisco Salas
    Objective: to conduct a literature review of Crohn's disease based on its causes, risks, and treatments.Method: a literature review based on narrative and systematic synthesis.
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    Novel mutations associated with nephrogenic diabetes insipidus. A clinical-genetic study
    (2015-04-21)
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    Alejandro García‐Castaño
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    Gustavo Pérez de Nanclares
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    Leire Madariaga
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    Mireia Aguirre
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    Embracing Monogenic Parkinson's Disease: The <scp>MJFF</scp> Global Genetic <scp>PD</scp> Cohort
    (2023-01-24)
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    Susen Schaake
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    Katja Lohmann
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    Shalini Padmanabhan
    ;
    Alexis Brice
    BACKGROUND: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and availability of clinical data and clinical trial-ready cohorts is limited. OBJECTIVE: The objectives are to (1) establish an international cohort of affected and unaffected individuals with PD-linked variants; (2) provide harmonized and quality-controlled clinical characterization data for each included individual; and (3) further promote collaboration of researchers in the field of monogenic PD. METHODS: We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data. All registered cases underwent thorough quality checks, and pathogenicity scoring of the variants and genotype-phenotype relationships were analyzed. RESULTS: We collected 3888 variant carriers for our analyses, reported by 92 centers (42 countries) worldwide. Of the included individuals, 3185 had a diagnosis of PD (ie, 1306 LRRK2, 115 SNCA, 23 VPS35, 429 PRKN, 75 PINK1, 13 DJ-1, and 1224 GBA) and 703 were unaffected (ie, 328 LRRK2, 32 SNCA, 3 VPS35, 1 PRKN, 1 PINK1, and 338 GBA). In total, we identified 269 different pathogenic variants; 1322 individuals in our cohort (34%) were indicated as not previously published. CONCLUSIONS: Within the MJFF Global Genetic PD Study Group, we (1) established the largest international cohort of affected and unaffected individuals carrying PD-linked variants; (2) provide harmonized and quality-controlled clinical and genetic data for each included individual; (3) promote collaboration in the field of genetic PD with a view toward clinical and genetic stratification of patients for gene-targeted clinical trials. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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    Sociodemographic Factors, Work Motivation, Emotional Intelligence, Quality of Work Life, and Their Association with Work Performance in Peruvian Health Workers
    (2023-09-18)
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    Cesar Alvarez-Guzman
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    Angely Alvarez-Guzman
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    Liset Z. Sairitupa-Sanchez
    Introduction: This study addresses the influence of Emotional Intelligence (EI), work motivation, and quality of work life on the performance of health workers in Peru. Considering the relevance of these variables in clinical contexts, especially during stressful situations like the COVID-19 pandemic. Objective: The aim was to determine how these sociodemographic and psychosocial factors are associated with work performance in this sector. Methods: A descriptive cross-sectional design was adopted, using a random sample of health workers from a significant hospital, with a minimum calculated sample size of 110 professionals. The tools used included the Quality of Life Scale, the Emotional Intelligence Scale, the Work Motivation Scale, and the Individual Work Performance Questionnaire. Results: The results showed higher participation of health workers between the ages of 28 and 37. A significant correlation was found between Emotional Intelligence (EI) and work performance (r = 0,398, p &lt; 0,01), as well as between quality of work life and work performance (r = 0,484, p &lt; 0,01). However, work motivation did not show a significant correlation with performance (r = 0,099, p &gt; 0,05). Additionally, the variables of being female and working in the care area were significantly related to better work performance. Conclusion: The study concludes that work performance in the health sector is positively influenced by Emotional Intelligence and quality of work life. These findings highlight the importance of emotional support, cooperation, and communication in health environments, as well as recognition through non-monetary incentives. This comprehensive approach may be key to improving productivity and the quality of patient care in health facilities.
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    Validation of an Organizational Climate Scale in health workers
    (2024-03-11)
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    Jeydi Raqui-Rojas
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    Liset Z. Liset Z.
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    Wilter C. Morales-García
    Introduction: organizational climate is a key factor in employee performance and satisfaction. In this study, the validity and reliability of an organizational climate scale in agroindustrial companies in Peru was examined. Objective: to analyze the psychometric properties of an organizational climate scale adapted to Peruvian Spanish. Methods: A methodological study was carried out. Demographic data were collected, as well as responses to an organizational climate questionnaire. Results: the data were analyzed using confirmatory factorial analysis (CFA). The reliability of the instrument was high (α = 0,92). However, the factor loadings of several items were not adequate, so a unidimensional model was tested, then a model with adequate factor loadings, and finally an optimal model. In this last 9-item model, the fit was optimal, and the factor loading was adequate for all items. Conclusion: overall, the organizational climate scale demonstrated good reliability and validity in this context of agroindustrial companies in Peru. However, some items needed to be revised to improve the scale's accuracy. These findings provide a valuable tool for measuring the organizational climate in these types of companies and pave the way for future research in this field
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    Effects of HPV 16 in women with cervical cancer: A narrative review
    (2026-01-01)
    Iris Mundaca Ruiz
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    Beky Bardales Pérez
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    Helen Roldán Tananta
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    Ruth Tello Satalaya
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    Liz Tuanama Rodríguez
    Objective: to identify associated factors and clinical factors in patients with diabetes.Method: literature review based on a narrative synthesis.Data sources: Scopus, Science direct, Web of sciencie, Google scholar, PubMed and SciELO.Data selection: The documents were selected and analyzed under a critical review of the literature taking into account the inclusion and exclusion criteria.Results: a corpus of 17 articles was analyzed, of which 7 performed quantitative analyses, 2 retrospective cohort studies, 3 observational studies, 1 experimental methodology study, 1 cross-sectional study, 1 systematic review and 2 descriptive studies.The population studied in the articles includes various categories: women between 30 and 65 years old, adolescents and adults over 60 years old, women attending gynecological check-ups, indigenous women from rural and urban areas and women with prevalence of cervical cancer and other types of carcinomas, in addition to studies for the development of prophylactic vaccines.The studies were carried out in various countries: 2 Turkey, 1 Spain, 1 Chile, 3 Ecuador, 3 China, 1 Indonesia, 1 Mexico, 1 Argentina, 2 Colombia, 1 Italy, each providing a unique perspective to the research.Negative cytology was analyzed in three articles highlighting its presence in healthy women carrying the Human Papillomavirus.Seven articles were also identified that address the prevalence and types of HPV, two that point to factors associated with the development of cervical cancer, and six that address high-and low-grade lesions.Regarding socioeconomic status, 12 articles were conducted in populations in low-income countries, only three were from high-income countries, and one was from a middle-income country.Conclusion: the review showed that HPV type 16 is strongly associated with cervical cancer, with significant impacts in diverse populations and socioeconomic contexts.The studies highlight severe symptoms and high mortality, highlighting the need to strengthen prevention and treatment, especially in resource-limited countries.
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    Factors associated, symptoms, and treatments of guillain-barré syndrome: a narrative review
    (2025-02-18)
    Emilia López-Peña
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    Diana Camizán-Julca
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    Jonathan Dávila-Pezo
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    Sayra Morales-Ruiz
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    Objective: To conduct a brief literature review on Guillain-Barré Syndrome (GBS), its associated factors, and available treatments. Design: Literature review based on a narrative synthesis.Databases: Scopus, ScienceDirect, SciELO, Google Scholar, and PubMed. Study Selection: Documents were selected through a critical literature review, considering inclusion and exclusion criteria. Results: The literature analysis included a corpus of 15 articles, comprising 2 statistical analyses, 6 narrative reviews, 3 systematic reviews, 2 observational studies, and 2 clinical cases. The studies primarily involved a population of adult men and women, children, and pregnant women, mostly from low-income and vulnerable backgrounds. Patients diagnosed with GBS were associated with COVID-19, Systemic Lupus Erythematosus (SLE), Posterior Reversible Encephalopathy Syndrome (PRES), Zika virus, and dengue. Conclusions: Research related to GBS highlights numerous causes and complications. GBS is significantly associated with muscle weakness, reduced mobility, and conditions such as SLE and PRES. During the COVID-19 pandemic, a slight increase in GBS cases was recorded. Although uncommon, GBS complications can lead to cardiovascular, respiratory, and gastrointestinal issues. Research does not explore in-depth preventive strategies or early management of these complications. There are currently limited treatments available to improve patient outcomes.