Alvarez Manrique, Victor Daniel

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Alvarez Manrique, Victor Daniel
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2011 - 201932020 - 202621

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  • Publicacion
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    Effects of HPV 16 in women with cervical cancer: A narrative review
    (2026-01-01)
    Mundaca Ruiz, Iris
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    Bardales Pérez, Beky
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    Roldán Tananta, Helen
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    Tello Satalaya, Ruth
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    Tuanama Rodríguez, Liz
    Objective: to identify associated factors and clinical factors in patients with diabetes.Method: literature review based on a narrative synthesis.Data sources: Scopus, Science direct, Web of sciencie, Google scholar, PubMed and SciELO.Data selection: The documents were selected and analyzed under a critical review of the literature taking into account the inclusion and exclusion criteria.Results: a corpus of 17 articles was analyzed, of which 7 performed quantitative analyses, 2 retrospective cohort studies, 3 observational studies, 1 experimental methodology study, 1 cross-sectional study, 1 systematic review and 2 descriptive studies.The population studied in the articles includes various categories: women between 30 and 65 years old, adolescents and adults over 60 years old, women attending gynecological check-ups, indigenous women from rural and urban areas and women with prevalence of cervical cancer and other types of carcinomas, in addition to studies for the development of prophylactic vaccines.The studies were carried out in various countries: 2 Turkey, 1 Spain, 1 Chile, 3 Ecuador, 3 China, 1 Indonesia, 1 Mexico, 1 Argentina, 2 Colombia, 1 Italy, each providing a unique perspective to the research.Negative cytology was analyzed in three articles highlighting its presence in healthy women carrying the Human Papillomavirus.Seven articles were also identified that address the prevalence and types of HPV, two that point to factors associated with the development of cervical cancer, and six that address high-and low-grade lesions.Regarding socioeconomic status, 12 articles were conducted in populations in low-income countries, only three were from high-income countries, and one was from a middle-income country.Conclusion: the review showed that HPV type 16 is strongly associated with cervical cancer, with significant impacts in diverse populations and socioeconomic contexts.The studies highlight severe symptoms and high mortality, highlighting the need to strengthen prevention and treatment, especially in resource-limited countries.
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    Hospital-acquired pneumonia: a narrative review
    (2026-01-01)
    Morales Garcia, Wilter Charming  
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    Alvarez Manrique, Victor Daniel  
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    Morales García, Wilter Eyvi Mardel  
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    Vásquez Lomas, Katherin Anais
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    Tangoa Pérez, Susy Caroly
    Objective: to conduct a literature review on hospital-acquired pneumonia through factors, treatment, and prevention.Method: as data sources, Scopus, SciELO, PubMed, Google Scholar were used.Data selection: Documents were selected and analyzed under a critical literature review, considering inclusion and exclusion criteria.Results: a corpus of 19 articles was analyzed, including 6 retrospective studies, 4 systematic reviews, 3 prospective studies, 2 narrative studies, 2 cross-sectional studies, 1 qualitative study, 1 observational study, 1 meta-analysis, one multiple logistic regression analysis, one longitudinal study, one analytical review, one phase III trial, one literature review, and one quantitative study.The population studied included pediatric patients, young people, adults, and the elderly.The studies were conducted in various countries, such as Spain, China, Mexico, Brazil, Canada, the Philippines, the United States, India, Egypt, Peru, France, Romania, Italy, Argentina, Oman, and the Czech Republic, each of which contributed a unique perspective to the research.Two articles addressed neurological factors, 11 focused on manifestations, and 6 dealt with predictive factors.The clinical condition of the patients in the studies, 8 articles analyzed the results of acute ischemic stroke (AIS), severe TBI, craniofacial trauma, moderate TBI, chest trauma, pulmonary contusion, acute diseases, hip fracture, chronic lung disease, periodontal disease, poor oral health, and comorbidities in terms of socioeconomic status.The studies were conducted in countries with diverse resources and incomes, reflecting improved access to effective diagnosis of hospital-acquired pneumonia.Conclusion: NIH and its mortality rate are associated with different factors, with timely diagnosis and appropriate treatment being essential to avoid complications.The collaboration of nursing staff and multidisciplinary collaboration is highlighted to achieve better control and reduce the incidence of nosocomial infections.
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    Crohn’s disease: a narrative review
    (2026-01-01)
    Morales Garcia, Wilter Charming  
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    Alvarez Manrique, Victor Daniel  
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    Morales García, Wilter Eyvi Mardel  
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    Vargas Ruiz, Piero Alexander
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    Pisco Salas, Bilha Raquel
    Objective: to conduct a literature review of Crohn's disease based on its causes, risks, and treatments.Method: a literature review based on narrative and systematic synthesis.
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    Mpox: Transmission, clinical manifestations, prevention, and treatment – a narrative review
    (2025-02-18)
    Sandoval-Urbano, Erica
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    Pimentel-Betancourt, Jhonny E.
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    Lozano-Gutierres, Kelita M.
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    Julca-Cano, Mirian
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    Alvarez Manrique, Victor Daniel  
    Objective:To identify the transmission methods, symptoms, complications, prevention, and treatment associated with Mpox. Design:Literature review based on a narrative synthesis. Data Sources:Web of Science, Google Scholar, Scielo, ScienceDirect, Redalyc, and Scopus. Study Selection:Documents were selected and analyzed through a critical literature review, considering inclusion and exclusion criteria. Results:A literature review was conducted with a corpus of 17 articles, including 11 narrative reviews, 2 systematic reviews, and 4 statistical analyses. Mpox is more prevalent among children, adults, pregnant women, and homosexual and bisexual individuals. The regions with the highest outbreak incidence are Asia, South America, Europe, the United States, and especially West and Central Africa, where it is endemic. Clinical conditions associated with Mpox include fever, skin rashes, abdominal pain, and meningitis, and it is strongly linked to HIV. Most reported cases have been among lower-class individuals, with some from the middle class. Conclusions: The Mpox virus is transmitted through various means, primarily contact, bodily fluids, and sexual relations between men. It significantly affects children and pregnant women and presents a range of symptoms, with skin lesions being the most frequent, followed by fever, headaches, oral lesions, and others. If left untreated or inadequately managed, it can lead to severe complications, with HIV-positive individuals and immunocompromised patients at the highest risk. Pneumonia can be fatal in severe cases. Good personal hygiene is recommended, and although there are no approved vaccines for Mpox, Tecovirimat and Brincidofovir show potential for approval in case of future outbreaks.
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    Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results
    (2020-12-02)
    Alvarez Manrique, Victor Daniel  
    BACKGROUND: World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs - remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a - in patients hospitalized with coronavirus disease 2019 (Covid-19). METHODS: We randomly assigned inpatients with Covid-19 equally between one of the trial drug regimens that was locally available and open control (up to five options, four active and the local standard of care). The intention-to-treat primary analyses examined in-hospital mortality in the four pairwise comparisons of each trial drug and its control (drug available but patient assigned to the same care without that drug). Rate ratios for death were calculated with stratification according to age and status regarding mechanical ventilation at trial entry. RESULTS: At 405 hospitals in 30 countries, 11,330 adults underwent randomization; 2750 were assigned to receive remdesivir, 954 to hydroxychloroquine, 1411 to lopinavir (without interferon), 2063 to interferon (including 651 to interferon plus lopinavir), and 4088 to no trial drug. Adherence was 94 to 96% midway through treatment, with 2 to 6% crossover. In total, 1253 deaths were reported (median day of death, day 8; interquartile range, 4 to 14). The Kaplan-Meier 28-day mortality was 11.8% (39.0% if the patient was already receiving ventilation at randomization and 9.5% otherwise). Death occurred in 301 of 2743 patients receiving remdesivir and in 303 of 2708 receiving its control (rate ratio, 0.95; 95% confidence interval [CI], 0.81 to 1.11; P = 0.50), in 104 of 947 patients receiving hydroxychloroquine and in 84 of 906 receiving its control (rate ratio, 1.19; 95% CI, 0.89 to 1.59; P = 0.23), in 148 of 1399 patients receiving lopinavir and in 146 of 1372 receiving its control (rate ratio, 1.00; 95% CI, 0.79 to 1.25; P = 0.97), and in 243 of 2050 patients receiving interferon and in 216 of 2050 receiving its control (rate ratio, 1.16; 95% CI, 0.96 to 1.39; P = 0.11). No drug definitely reduced mortality, overall or in any subgroup, or reduced initiation of ventilation or hospitalization duration. CONCLUSIONS: These remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19, as indicated by overall mortality, initiation of ventilation, and duration of hospital stay. (Funded by the World Health Organization; ISRCTN Registry number, ISRCTN83971151; ClinicalTrials.gov number, NCT04315948.).
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    Establishing an online resource to facilitate global collaboration and inclusion of underrepresented populations: Experience from the MJFF Global Genetic Parkinson’s Disease Project
    (2023-10-03)
    Eva‐Juliane Vollstedt  
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    Harutyun Madoev
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    Anna Aasly
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    Azlina Ahmad‐Annuar
    ;
    Bashayer Al‐Mubarak
    Parkinson's disease (PD) is the fastest-growing neurodegenerative disorder, currently affecting ~7 million people worldwide. PD is clinically and genetically heterogeneous, with at least 10% of all cases explained by a monogenic cause or strong genetic risk factor. However, the vast majority of our present data on monogenic PD is based on the investigation of patients of European White ancestry, leaving a large knowledge gap on monogenic PD in underrepresented populations. Gene-targeted therapies are being developed at a fast pace and have started entering clinical trials. In light of these developments, building a global network of centers working on monogenic PD, fostering collaborative research, and establishing a clinical trial-ready cohort is imperative. Based on a systematic review of the English literature on monogenic PD and a successful team science approach, we have built up a network of 59 sites worldwide and have collected information on the availability of data, biomaterials, and facilities. To enable access to this resource and to foster collaboration across centers, as well as between academia and industry, we have developed an interactive map and online tool allowing for a quick overview of available resources, along with an option to filter for specific items of interest. This initiative is currently being merged with the Global Parkinson's Genetics Program (GP2), which will attract additional centers with a focus on underrepresented sites. This growing resource and tool will facilitate collaborative research and impact the development and testing of new therapies for monogenic and potentially for idiopathic PD patients.
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    Validation of an Organizational Climate Scale in health workers
    (2024-03-11)
    Flor Damiano-Aulla, Flor Damiano-Aulla
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    Raqui-Rojas, Jeydi
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    Alvarez Manrique, Victor Daniel  
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    Sairitupa Sanchez, Liset Zenaida  
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    Morales Garcia, Wilter Charming  
    Introduction: organizational climate is a key factor in employee performance and satisfaction. In this study, the validity and reliability of an organizational climate scale in agroindustrial companies in Peru was examined. Objective: to analyze the psychometric properties of an organizational climate scale adapted to Peruvian Spanish. Methods: A methodological study was carried out. Demographic data were collected, as well as responses to an organizational climate questionnaire. Results: the data were analyzed using confirmatory factorial analysis (CFA). The reliability of the instrument was high (α = 0,92). However, the factor loadings of several items were not adequate, so a unidimensional model was tested, then a model with adequate factor loadings, and finally an optimal model. In this last 9-item model, the fit was optimal, and the factor loading was adequate for all items. Conclusion: overall, the organizational climate scale demonstrated good reliability and validity in this context of agroindustrial companies in Peru. However, some items needed to be revised to improve the scale's accuracy. These findings provide a valuable tool for measuring the organizational climate in these types of companies and pave the way for future research in this field
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    Covid-19 with gastrointestinal symptoms: a narrative review
    (2025-02-18)
    Vásquez-Granda, Janeth
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    Tarrillo-Olivos, Jessy C.
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    Pereyra-Urbina, Naomy R.
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    Paola, Jhanina Paola Jhanina
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    Cabanillas-Carrero, Yajahira M.
    Objective: This study aims to conduct a brief literature review on gastrointestinal problems caused by COVID-19, characterized by symptoms and sequelae.Design: Literature review based on a narrative synthesis.Data sources: Databases: Scopus, Web of Science, Science Direct, Scielo, Google Scholar.Study selection: The documents were selected and analyzed under a critical literature review, considering inclusion and exclusion criteria.Results: Out of a total of 461,161 potentially relevant articles, the analysis was based on 19 studies, of which 10 were statistical analyses, 5 were narrative reviews, and 3 were systematic reviews. Patients involved in these studies not only exhibited gastrointestinal conditions due to COVID-19 but also experienced neurological, cardiovascular issues, and pneumonia. The study populations included children, young adults, adults, and pregnant women, with studies conducted in the United States, China, Morocco, Iran, Mexico, Colombia, and Brazil.Conclusions: COVID-19 has caused gastrointestinal problems such as diarrhea, abdominal pain, vomiting, and persistent sequelae like irritable bowel syndrome (IBS), erectile dysfunction, and functional dyspepsia. Adults also face psychosocial disorders, such as anxiety and depression. Long-term sequelae include cognitive disorders, fatigue, hypertension, and chronic respiratory problems. Severe patients are at higher risk for coagulopathies and require intensive care. These sequelae significantly impact quality of life, increase psychological stress, and contribute to economic burdens.
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    Embracing Monogenic Parkinson's Disease: The MJFF Global Genetic PD Cohort
    (2023-01-24)
    Eva‐Juliane Vollstedt  
    ;
    Susen Schaake
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    Katja Lohmann
    ;
    Shalini Padmanabhan
    ;
    Alexis Brice
    BACKGROUND: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and availability of clinical data and clinical trial-ready cohorts is limited. OBJECTIVE: The objectives are to (1) establish an international cohort of affected and unaffected individuals with PD-linked variants; (2) provide harmonized and quality-controlled clinical characterization data for each included individual; and (3) further promote collaboration of researchers in the field of monogenic PD. METHODS: We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data. All registered cases underwent thorough quality checks, and pathogenicity scoring of the variants and genotype-phenotype relationships were analyzed. RESULTS: We collected 3888 variant carriers for our analyses, reported by 92 centers (42 countries) worldwide. Of the included individuals, 3185 had a diagnosis of PD (ie, 1306 LRRK2, 115 SNCA, 23 VPS35, 429 PRKN, 75 PINK1, 13 DJ-1, and 1224 GBA) and 703 were unaffected (ie, 328 LRRK2, 32 SNCA, 3 VPS35, 1 PRKN, 1 PINK1, and 338 GBA). In total, we identified 269 different pathogenic variants; 1322 individuals in our cohort (34%) were indicated as not previously published. CONCLUSIONS: Within the MJFF Global Genetic PD Study Group, we (1) established the largest international cohort of affected and unaffected individuals carrying PD-linked variants; (2) provide harmonized and quality-controlled clinical and genetic data for each included individual; (3) promote collaboration in the field of genetic PD with a view toward clinical and genetic stratification of patients for gene-targeted clinical trials. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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    Diabetes and kidney failure: a narrative review
    (2026-01-01)
    Rojas Saavedra, Mildre
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    Ramírez López, Karen
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    Cubas Flores, Evelin
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    Oliva Pisco, Maythe
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    Tapullima Cahuaza, Esther
    Objective: to conduct a literature review on diabetes and kidney failure, focusing on risk factors, treatments, and complications.Method: literature review with narrative synthesis.Data sources: Scopus, ScienceDirect, and PubMed.Data selection: Documents were selected and analyzed using critical review, considering inclusion and exclusion criteria.Results: a corpus of 25 articles was analyzed, of which 6 were retrospective, longitudinal, systematic, narrative, correlational, and observational studies.The population included children, adolescents, adults, and older adults (18 to 86 years), as well as general population registries in various settings.The studies were conducted in several countries: Hong Kong, Taiwan, Japan, Denmark, Thailand, Mexico, Finland, Korea, India, China, Glasgow, Babylon,
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