Mostrando 1 - 10 de 21
  • Algunas métricas están bloqueadas por su 
    Item type:Publicación,
    Characteristics and quality of systematic reviews led by Peruvian authors: A scoping review
    (Elsevier Ltd, 2024-08-24)
    Brañez-Condorena, Ana
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    Mejia, Jhonatan R.
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    Chavez-Rimache, Lesly Karem
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    Fernandez-Guzman, Daniel
    Background Systematic reviews (SRs) worldwide suffer from methodological deficiencies, potentially biasing intervention decisions, and Peruvian SRs are no exception. Evaluating SRs led by Peruvian researchers is a crucial step to enhance quality and transparency in decision-making and to identify topics where SRs are either scarce or prioritized for research. Objective To describe the characteristics and assess the methodological quality of SRs with Peruvian first authors. Methods We conducted a scoping review within the Scopus database on January 5, 2023. We aimed to identify published SRs of interventions in which the first author had a Peruvian affiliation, published between 2013 and 2022. We evaluated the methodological quality of these SRs using the AMSTAR 2 tool. We assessed the factors associated with the AMSTAR 2 score using adjusted mean differences (aMD), including their 95 % confidence intervals (95 % CI). Results We identified 95 eligible SRs, with a clear upward trend. SRs were primarily published in Q1 (43.2 %) and Q2 (23.2 %) journals, predominantly affiliated with institutions in Lima (90.5 %). Areas like infectious diseases (20.0 %) and dentistry (18.9 %) were most frequent. AMSTAR 2 assessments highlighted deficiencies, with few SRs reporting prior protocols (37.9 %), comprehensive search strategies (23.2 %), explanations for excluded studies (20.0 %), adequate descriptions of included studies (38.3 %), or funding sources (19.1 %). Notably, SRs in Q4 journals (aMD: -19.7, 95 % CI: -33.8 to -5.5) and those on surgical interventions (aMD: -22.6, 95 % CI: -34.7 to -10.4) had lower AMSTAR 2 scores. Conclusions Although Peruvian-led SRs are increasingly being published, critical deficiencies are common, especially in reporting protocols, search strategies, study descriptions, and funding sources. Addressing these gaps is pivotal for enhancing the credibility and utility of these SRs in informing decision-making.
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    Item type:Publicación,
    Association between smoking and anemia in adult women in Peru: analysis of a national survey (ENDES) 2023
    Background Anemia is a major public health issue that disproportionately affects women of reproductive age. While tobacco use may influence hemoglobin levels through physiological mechanisms, its association with anemia remains unclear. This study aimed to evaluate the relationship between smoking and anemia in adult women in Peru using nationally representative data. Methods Cross-sectional study based on secondary data from a national survey (ENDES 2023). Women aged 18 to 49 years with complete information on the variables of interest were included. The independent variable was smoking, and the dependent variable was the anemia status. To evaluate the association between variables, Poisson regression with robust variance was used to calculate prevalence ratios (PR). Results A total of 13 036 women with a mean age of 33.0 years were analyzed. No significant association was found between cigarette smoking in the last 12 months (aPR: 1.01; 95% CI: 0.82 to 1.24), smoking in the last 30 days (aPR: 0.89; 95% CI: 0.66 to 1.22), or daily smoking (aPR: 1.08; 95% CI: 0.55 to 2.14) and the prevalence of anemia. On the other hand, a higher prevalence of anemia was observed in women aged 30 to 49 years. While the factors associated with a lower prevalence of anemia were black ethnicity, overweight, obesity, and living in small cities. Conclusion No significant association was found between smoking and the presence of anemia in Peruvian adult women. However, factors such as age, nutritional status and ethnicity were associated with the prevalence of anemia.
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    Item type:Publicación,
    Methodological characteristics of Peruvian clinical practice guidelines, 2018 – 2023: A scoping review
    (Public Library of Science, 2025-12-31)
    Brañez-Condorena, Ana
    ;
    Solis-Chimoy, Blanca
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    Mejia, Jhonatan R.
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    Chavez-Rimache, Lesly Karem
    ;
    Background Clinical practice guidelines (CPGs) must be developed through a rigorous and transparent methodology to ensure the appropriateness and reliability of their recommendations. In Peru, little is known regarding how CPGs adhere to established methodological standards. Objective To describe the methodological characteristics of CPGs developed and published in Peru between 2018 and 2023. Methods We conducted a scoping review and searched CPGs on Google, Google Scholar, and relevant local organizational websites. To be included, CPGs had to self-identify as such, have full-text versions available online, provide explicit methodological descriptions, and base their recommendations on systematic reviews, with publication dates between January 2018 and December 2023. We presented the results descriptively and analyzed the methodological differences among CPGs from different organizations using Fisher’s exact tests. Results Out of 312 records assessed, 88 CPGs met the inclusion criteria. We found a declining publication trend over the study period: 39 CPGs were published in 2018–2019, 30 in 2020–2021, and 19 in 2022–2023. Most CPGs (60.2%) were developed by the Peruvian Social Security Health Insurance (EsSalud). Oncology was the most prevalent specialty of the CPGs (20.5%) and most CPGs (96.6%) included disease management. 23.7% of CPGs used ≥ 3 search engines, and 76.3% showed the risk of bias assessment. Although most CPGs indicated using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) methodology (94.3%), 30.7% missed Summary of Findings tables, 38.6% did not include Evidence-to-Decision frameworks, and only 5.7% used minimal important difference for at least one question. Additionally, economic analyses were infrequently sought or included. Conclusions This study highlights significant methodological deficiencies in Peruvian CPGs, including inadequate reporting of search strategies, bias assessments, and key GRADE components. Addressing these shortcomings is crucial for enhancing the quality and reliability of CPGs and promoting equitable healthcare delivery in Peru.
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    Item type:Publicación,
    Association between self-reported evidence-based medicine competencies and prescribing of drugs without scientific evidence against mild COVID-19 among recently graduated physicians in Peru
    (Elsevier Ltd, 2023-04-01)
    Fernandez-Guzman, Daniel
    ;
    Caira-Chuquineyra, Brenda
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    Baca-Rondan, Fiorella
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    Yucra-Sosa, Maria Cristina
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    Ccami-Bernal, Fabricio
    Objective To evaluate the association between self-rated evidence-based medicine (EBM) competencies and the prescription of drugs without scientific evidence against mild COVID-19 (present with any of the signs and symptoms of COVID-19 but who do not have shortness of breath, dyspnea, or abnormal chest imaging) among recently graduated physicians in Peru. Methods We conducted an analytical cross-sectional study where we evaluated a non-probability sample of recently graduated physicians during June and July 2021 (end of second wave of COVID-19 in Peru). Self-rated EBM competencies were assessed by four domains (formulation of a clinical question, search, analysis, and application) using a Likert scale with scores from zero to four ("Very inadequate" = 0, to "Very Adequate" = 4), it was considered as "Adequate" if the score was three or four. In addition, the variable "General competence on EBM" was rated as "Adequate" if in all domains evaluated it presented an adequate self-rating. For the outcome, drug prescription, we considered the use of ivermectin, azithromycin, other antibiotics, hydroxychloroquine, dexamethasone, and anticoagulants (drugs with no efficacy demonstrated for patients with mild COVID-19). To assess the association, we used Poisson regression models with robust variances and obtaining crude (cPR) and adjusted (aPR) prevalence ratios with their 95% confidence intervals (95%CI). Results Of a total of 239 physicians included 70.7% prescribed at least one drug without scientific evidence. A total of 51.1% reported adequate ratings in all evaluated domains of EBM. Self-rating the "Clinical Question Formulation" competency as adequate was associated with a lower frequency of prescribing medications for mild COVID-19 (aPR: 0.93; 95% CI: 0.91-0.95). While self-rating as adequate the competency of "Identify possible implications of investigations" was associated with an increase in the prescription of such drugs (aPR: 1.14; 95% CI: 1.09-1.20). Additionally, self-rating all domains as adequate were associated with less prescription (aPR: 0.93; 95% CI: 0.90-0.96). Conclusion Seven out of ten recently graduated physicians prescribed some type of medication without scientific evidence to treat patients with mild COVID-19. Having adequate self-perceived EBM competencies was associated with a lower frequency of prescribing medications without scientific evidence to manage patients with mild COVID-19.
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    Item type:Publicación,
    Prevalence and incidence of diabetic retinopathy in patients with diabetes of Latin America and the Caribbean: A systematic review and meta-analysis
    Objectives This systematic review aimed to assess the prevalence and incidence of diabetic retinopathy in patients with diabetes of Latin America and the Caribbean. Methods We searched Web of Science (WoS)/Core Collection, WoS/MEDLINE, WoS/Scielo, Scopus, PubMed/Medline and Embase databases until January 16, 2023. We meta-analyzed prevalences according to type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Results Forty-three prevalence studies (47 585 participants) and one incidence study (436 participants) were included. The overall prevalence of retinopathy in patients with T1DM was 40.6% (95% CI: 34.7 to 46.6; I2: 92.1%) and in T2DM was 37.3% (95% CI: 31.0 to 43.8; I2: 97.7), but the evidence is very uncertain (very low certainty of evidence). In meta-regression, we found that age (T1DM) and time in diabetes (T2DM) were factors associated with the prevalence. On the other hand, one study found a cumulative incidence of diabetic retinopathy of 39.6% at 9 years of follow-up. Conclusions Two out of five patients with T1DM or T2DM may present diabetic retinopathy in Latin America and the Caribbean, but the evidence is very uncertain. This is a major public health problem, and policies and strategies for early detection and opportunely treatment should be proposed.
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    Item type:Publicación,
    Methodological characteristics of health technology assessments developed in Peru, 2019-2021
    (Medical Body of the Almanzor Aguinaga Asenjo National Hospital, 2022-10-04)
    Taype-Rondán, Álvaro Renzo
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    Quincho-Lopez, Alvaro
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    Martinez-Rivera, Raisa N.
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    Mejia, Jhonatan R.
    Introducción: Se han reportado limitaciones para cumplir con buenas prácticas metodológicas en el desarrollo de evaluaciones de tecnologías sanitarias (ETS). Por ello, el objetivo del presente estudio fue describir las características metodológicas de las ETS elaboradas en Perú, entre 2019-2021. Métodos: Estudio descriptivo. Buscamos las instituciones peruanas que elaboren ETS cuyos informes sean accesibles al público. Recolectamos el número total de ETS que elaboraron estas instituciones por año, y recolectamos las características de las ETS elaboradas durante el periodo 2019-2021. Resultados: Tres instituciones peruanas elaboraron al menos tres ETS públicas entre 2019-2021: El Instituto de Evaluación de Tecnologías en Salud e Investigación (IETSI) (n=142), la Unidad de Análisis y Generación de Evidencias en Salud Pública (UNAGESP) (n=60), y el Instituto Nacional de Enfermedades Neoplásicas (INEN) (n=40). Las ETS de UNAGESP no brindaron una decisión, mientras que 35,9% de las de IETSI y 70,0% de las de INEN concluyeron a favor de la tecnología evaluada. Todas las ETS explicaron la metodología usada y realizaron búsquedas sistemáticas. Sin embargo, pocas presentaron la evaluación de riesgo de sesgo de los estudios incluidos (17,4%), la certeza de la evidencia (4,6%), o los beneficios y daños por desenlace (14,4%). Ninguna ETS realizó estudios de costos ni explicitó la metodología usada para llegar a la decisión. Conclusiones: Las ETS evaluadas presentaron aspectos metodológicos favorables y ciertas falencias (en temas como el reporte en la evaluación de riesgo de sesgo y certeza de la evidencia, presentación de beneficios y daños por desenlace, y explicitación de la metodología usada para tomar decisiones).
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    Item type:Publicación,
    Prevalence of computer vision syndrome: A systematic review and meta-analysis
    (Spanish Council of Optometry, 2024)
    Ccami-Bernal, Fabricio
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    Romero-Robles, Milton A.
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    Barriga-Chambi, Fernanda
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    Purpose This review aimed to estimate the prevalence of computer vision syndrome (CVS) in the general population and subgroups. Methods A search was conducted in the following the databases: PubMed, SCOPUS, EMBASE, and Web of Science until February 13, 2023. We included studies that assessed the prevalence of CVS in any population. The Joanna Briggs Institute's critical appraisal tool was used to evaluate the methodological quality. A meta-analysis of the prevalence of CVS was done using a random-effects model, assessing the sources of heterogeneity using subgroup and meta-regression analyses. Results A total of 103 cross-sectional studies with 66 577 participants were included. The prevalence of CVS was 69.0% (95% CI: 62.3 to 75.3; I2: 99.7%), ranging from 12.1 to 97.3% across studies. Point prevalence was higher in women than in men (71.4 vs. 61.8%), university students (76.1%), Africa (71.2%), Asia (69.9%), contact lens wearers (73.1% vs. 63.8%) in studies conducted before the COVID-19 pandemic (72.8%), and in those that did not use the CVS-Q questionnaire (75.4%). In meta-regression, using the CVS-Q scale was associated with a lower prevalence of CVS. Conclusion Seven out of ten people suffer from CVS. Preventive strategies and interventions are needed to decrease the prevalence of this condition which can affect productivity and quality of life. Future studies should standardize a definition of CVS.
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    Item type:Publicación,
    Factors associated with the consumption of medicinal plants for the prevention of COVID-19 in peruvian population: a cross-sectional study
    (2024-05-08)
    Ccami-Bernal, Fabricio
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    Rojas-Miliano, Cristhian
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    Fernandez-Guzman, Daniel
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    Quispe-Vicuña, Carlos
    Objetivos. Determinar los factores asociados al consumo de plantas medicinales como prevención de la COVID-19 en la población peruana. Materiales y métodos. Se evaluó población mayor de 18 años, residentes en Perú y sin antecedentes de enfermedad por COVID-19. Los factores asociados al consumo de plantas medicinales se evaluaron mediante un modelo de regresión de Poisson con varianzas robustas. Resultados. De 3231 participantes incluidos, el 84,6% eran jóvenes (18-29 años), el 62,7% eran mujeres y el 59,7% consumía alguna planta medicinal para prevenir la COVID-19. Los factores asociados al consumo de plantas medicinales para prevenir el contagio de COVID-19 fueron residir en la sierra peruana, haber tenido un familiar diagnosticado con COVID-19, haber tenido un familiar fallecido por COVID-19, considerar que su familia se encuentra en mayor riesgo de infección, haber usado medicamentos o dióxido de cloro paraprevenir la COVID-19, tener información médica como principal fuente de información sobre la COVID-19, pensar que las plantas medicinales son efectivas para prevenir la enfermedad COVID-19 o no estar informado sobre su eficacia. Conclusión. El 60% de los participantes reportó haber consumido alguna planta medicinal para prevenir la COVID-19. Es importante que las autoridades apliquen estrategias de comunicación sobre lo que implica el consumo de plantas medicinales, priorizando los grupos poblacionales que tienen mayores patrones de consumo.
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    Item type:Publicación,
    The impact of the COVID-19 pandemic on HIV testing in Peru: an interrupted time series analysis from 2014 to 2022
    (BioMed Central Ltd, 2025-01-07)
    Yrene-Cubas, Robinson A.
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    Pérez-Castilla, Jesus
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    Reynaga-Cottle, Daniel E.
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    Bringas, Maria José
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    Objectives Our objective was to evaluate the impact of COVID-19 on the proportion of past-year HIV testing in Peru. Methods Utilizing data from the National Demographic and Health Survey of Peru from 2014 to 2022, we conducted an interrupted time series analysis. The proportion of past-year HIV testing per quarter of each year was considered our unit of analysis. Statistical analysis involved segmented regression with Newey-West standard errors, dividing each year of evaluation into four quarters. Additionally, we applied an Autoregressive Integrated Moving Average (ARIMA) model. Results We included 211,359 participants aged 15 to 49 years. The proportion of past-year HIV testing in Peru showed a mean decrease of 8.33% (95%CI: -10.73% to -5.93%) after the COVID-19 lockdown (from August-2020) compared to the previous period (before March-2020). Prior to lockdown, there was a mean quarterly increase of 0.30% (95%CI: 0.21-0.40%) in testing proportion, while after the lockdown, there was a mean quarterly decrease of -0.24% (95%CI: -0.56-0.09%). HIV testing declined in 23 of the 25 regions, ranging from - 23.7% to -3.0%, except in Amazonas and Cajamarca, where increases of 5.3% and 6.8% were observed. Predictions of counterfactual values without the pandemic using the ARIMA model revealed a percentage drop of -9.20% (95%CI: -13.70 to -4.80) in observed compared to predicted values. Conclusions This study highlights the decrease in proportion of past-year HIV testing in Peru following the COVID-19 lockdown, emphasizing the urgent need for targeted interventions to address disparities and ensure equitable access to testing services.
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    Item type:Publicación,
    Bibliometric Analysis and Health Evidence Map of Scientific Production on COVID-19 in Peru; Análisis bibliométrico y mapa de evidencia sanitaria de la producción científica sobre COVID-19 en Perú
    (Centro Nacional de Informacion de Ciencias Medicas, 2023)
    De-Los-Rios-Pinto, Abraham
    ;
    Fernandez-Guzman, Daniel
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    ;
    Benito-Vargas, Raysa M.
    ;
    Caira-Chuquineyra, Brenda
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