Soriano Moreno, David

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Soriano Moreno, David
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Soriano Moreno, David
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Soriano-Moreno, David R.
Soriano Moreno R. David
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Universidad Peruana Unión
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  • Publicacion
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    Bibliometric Analysis and Health Evidence Map of Scientific Production on COVID-19 in Peru; Análisis bibliométrico y mapa de evidencia sanitaria de la producción científica sobre COVID-19 en Perú
    (Centro Nacional de Informacion de Ciencias Medicas, 2023)
    De-Los-Rios-Pinto, Abraham
    ;
    Fernandez-Guzman, Daniel
    ;
    Soriano Moreno, David  
    ;
    Benito-Vargas, Raysa M.
    ;
    Caira-Chuquineyra, Brenda
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  • Publicacion
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    Discrimination and mental health in the minority sexual population: Cross-sectional analysis of the first peruvian virtual survey
    (2022-06-03)
    Soriano Moreno, David  
    ;
    Saldaña-Cabanillas, David
    ;
    Vasquez-Yeng, Luigy
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    Valencia-Huamani, Javier Antonio
    ;
    Alave Rosas, Jorge Luis  
    OBJECTIVE: This study sought to evaluate the association between discrimination and having mental health problems in the past 12 months in the sexual minority population in Peru. METHODS: We conducted a cross-sectional analysis of a secondary database corresponding to the first LGBTI survey in Peru in 2017. We included adults who self-identified their sexual orientation as gay, lesbian, bisexual, pansexual, or asexual/others. Both the exposure and dependent variables were self-reported by the participants. Multivariable Poisson regression was used to determine the association by calculating adjusted prevalence ratios (APR) with 95% confidence intervals (95% CI). RESULTS: Out of 9760 respondents, more than two-thirds of the participants reported having been discriminated against or having experienced violence at some time in their lives (70.3%) and one-fourth reported having mental health problems (23.8%). In the multivariable regression model, the prevalence of mental health problems in the last 12 months was 72% higher for the group of individuals who experienced discrimination when compared with the group that did not experience discrimination (APR = 1.72, 95% CI 1.57-1.88). The association was stronger among who self-identified lesbians (APR = 2.08, 95% CI 1.65-2.64). CONCLUSION: The prevalence of mental health problems and discrimination was high in this population. In addition, we found a statistically significant association between discrimination and the occurrence of mental health problems in the last 12 months.
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    Ticagrelor Versus Clopidogrel in Patients With Chronic Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis
    (John Wiley and Sons Inc, 2025-09-09)
    Pinedo-Avila, Johann Bill
    ;
    Valera-Cabrera, Jessica Lucia
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    Avalos-Rodríguez, Ana
    ;
    Fernández-Poma, Sarita Milagros
    ;
    Castro, Carlos Enrique Martínez
    Background Current guidelines recommend clopidogrel in patients with chronic coronary syndrome (CCS) undergoing percutaneous coronary intervention (PCI), yet the comparative benefits are unclear. Aims The aim of this study was to evaluate the efficacy and safety of ticagrelor versus clopidogrel in patients with CCS undergoing PCI. Methods We searched PubMed/MEDLINE, EMBASE, CENTRAL databases from inception to February 15, 2025. We included parallel randomized controlled trials (RCTs) involving adults with CCS undergoing PCI, where the intervention group received ticagrelor as maintenance therapy and the control group received clopidogrel. Primary outcomes included all‐cause or cardiovascular mortality, myocardial infarction, quality of life, heart failure, stroke/transient ischemic attack (TIA), revascularization, and adverse events. Study selection and data extraction were conducted independently. We determined the certainty of evidence using the GRADE approach. Results We included nine RCTs, with 3370 patients. Compared to clopidogrel, ticagrelor probably results in no important difference in cardiovascular mortality and hospital stay; may not have an important effect on stroke and/or TIA; and may not have an important effect on all‐cause mortality, heart failure, and revascularization, but the evidence is very uncertain. Additionally, the evidence is very uncertain about the effect on myocardial infarction. Regarding safety outcomes, ticagrelor probably results in no important difference in major bleeding, minor bleeding, any bleeding, or dyspnea. However, it probably increases the risk of chest pain/tightness ( + 7.5 per 100; 95% CI: +1.4 to +21.7). Conclusion In patients with CCS undergoing PCI, ticagrelor probably has a similar efficacy and safety to clopidogrel in most cardiovascular outcomes. However, it probably increases the risk of chest pain/tightness.
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    Percepciones e intención de los padres de vacunar a sus hijos menores de 12 años contra la COVID-19: Estudio transversal en Perú
    (2022-01-11)
    Gonzales Zamora, Jose
    ;
    Soriano Moreno, David  
    ;
    Soriano Moreno, Anderson Nelver Elías  
    ;
    Ponce-Rosas, Linda
    ;
    De-Los-Ríos-Pinto, Abraham
    Objetivos: Evaluar las percepciones e intención de los padres de vacunar a sus hijos menores de 12 años en Perú. Metodología: Estudio transversal analítico a partir de una encuesta en línea (25 de noviembre al 6 de diciembre del 2021) para padres de niños menores de 12 años que recopiló la percepción sobre el riesgo de contagio por COVID-19 en sus hijos, sobre la necesidad de vacunación y sobre los eventos adversos relacionados con la vacuna. Evaluamos los factores asociados a la intención de vacunación mediante razones de prevalencia crudas (RPc) y ajustadas (RPa) con intervalos de confianza al 95% (IC 95%). Resultados: El 83.5% de los padres tenían la intención de vacunar a sus hijos menores de 12 años. En el análisis multivariado, los factores asociados a una disminución de la intención de vacunación fueron pensar que la vacuna no es necesaria (RPa: 0.65; IC 95% 0.44 – 0,94), que no protegería (RPa: 0.14; IC 95% 0.03 – 0.63), que no sería segura (RPa: 0.80; IC 95% 0.70 – 0.92) y que ocasionaría efectos negativos a largo plazo (RPa: 0.92; IC 95% 0.85 – 1.00). Por otro lado, residir en la Selva (RPa: 1.09; IC 95%: 1.03 – 1.15) o en la Sierra (RPa: 1.06; IC 95%: 1.00 – 1.11) se asoció a una mayor prevalencia de intención. Conclusiones: En Perú, un 16.5% de padres no vacunaría a sus hijos menores de 12 años, ya que perciben que la vacuna no es necesaria y no protegería contra la COVID-19, además de tener la preocupación de posibles eventos adversos.
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    Association between smoking and anemia in adult women in Peru: analysis of a national survey (ENDES) 2023
    (BioMed Central Ltd, 2025-08-19)
    Torrejon Echaccaya, Karina Isabel  
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    Mathews Haro, Nelson Jair  
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    Rodriguez Simbron, David  
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    Soriano Moreno, David  
    Background Anemia is a major public health issue that disproportionately affects women of reproductive age. While tobacco use may influence hemoglobin levels through physiological mechanisms, its association with anemia remains unclear. This study aimed to evaluate the relationship between smoking and anemia in adult women in Peru using nationally representative data. Methods Cross-sectional study based on secondary data from a national survey (ENDES 2023). Women aged 18 to 49 years with complete information on the variables of interest were included. The independent variable was smoking, and the dependent variable was the anemia status. To evaluate the association between variables, Poisson regression with robust variance was used to calculate prevalence ratios (PR). Results A total of 13 036 women with a mean age of 33.0 years were analyzed. No significant association was found between cigarette smoking in the last 12 months (aPR: 1.01; 95% CI: 0.82 to 1.24), smoking in the last 30 days (aPR: 0.89; 95% CI: 0.66 to 1.22), or daily smoking (aPR: 1.08; 95% CI: 0.55 to 2.14) and the prevalence of anemia. On the other hand, a higher prevalence of anemia was observed in women aged 30 to 49 years. While the factors associated with a lower prevalence of anemia were black ethnicity, overweight, obesity, and living in small cities. Conclusion No significant association was found between smoking and the presence of anemia in Peruvian adult women. However, factors such as age, nutritional status and ethnicity were associated with the prevalence of anemia.
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    Green space exposure and type 2 diabetes mellitus incidence: A systematic review
    (Elsevier Ltd, 2023-05-07)
    Ccami-Bernal, Fabricio
    ;
    Soriano Moreno, David  
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    Fernandez-Guzman, Daniel
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    Tuco, Kimberly G.  
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    Castro Diaz, Sharong Dayan  
    Introduction Epidemiological studies have suggested that exposure to green spaces is associated with a lower prevalence of diabetes. The aim of this systematic review was to summarize the evidence on green spaces and diabetes mellitus II (T2DM) in longitudinal studies. Methods We searched PubMed, SCOPUS, Web of Science (WoS)/Core Collection, WoS/MEDLINE, and EMBASE until February 2023. We included cohort studies that assessed the incidence of T2DM according to the level of exposure to green spaces. Two authors independently performed study selection, data extraction, and analysis of risk of bias. No meta-analysis was performed due to clinical heterogeneity between studies. Results We included 13 cohort studies with a sample size ranging from 1700 to 1 922 545 participants. Studies presented different ways of defining (quartiles, percentages) and measuring (tools, buffers) green spaces. Similarly, the definition of T2DM was heterogeneous (self-reports, medical records, clinical criteria). Twelve studies showed that individuals with higher exposure to green spaces had a decreased incidence of T2DM. Out of these 12 studies, 10 revealed statistically significant differences. All studies were of high methodological quality, except for one. Conclusion Our findings suggest that exposure to green space could be a protective factor for the development of T2DM. Promoting policies to preserve and increase green space could help to reduce T2DM at the community level. More standardization of green space exposure definition is needed in studies on green space and T2DM.
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    Association between weight status and migraine in the paediatric population: a systematic review and meta-analysis
    (Frontiers Media SA, 2023-11-14)
    Quispe-Vicuña, Carlos
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    Soriano Moreno, David  
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    De-Los-Rios-Pinto, Abraham
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    Díaz-Ledesma, Luz A.
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    Fernandez-Guzman, Daniel
    Introduction An association between weight status and migraine has been previously reported; however, this relationship has only been studied in adults, not in the paediatric population. Objective To evaluate the association between weight status and migraine in the paediatric population. Methods We searched PubMed/Medline, Scopus, Web of Science, Ovid Medline, and Embase using a cut-off date of May 2023. We included observational studies that evaluated the association between weight status (underweight, overweight, obese, and excess weight) and migraine in the paediatric population (children and adolescents). Normal weight was the comparator. The outcome was migraine (all types, episodic and chronic). We performed meta-analyses using a random-effects model to estimate the pooled effects for each outcome. Sensitivity analysis was performed based on study design and risk of bias (using the Newcastle–Ottawa Scale). Certainty of evidence was assessed using the GRADE approach. Results Eight studies (6 cross-sectional, 1 case-control and 1 cohort) covering 16,556 patients were included. The overall certainty of evidence was very low for the association between overweight, obesity, and excess weight with migraine. In the sensitivity analysis, meta-analyses of studies with a low risk of bias found that the overweight population probably had an increased odds of migraine (OR: 1.70; 95% CI: 1.14 to 2.53; I2 = 32.3%, p = 0.224) and that excess weight may increase the odds of migraine (OR: 1.58; 95% CI: 1.06 to 2.35; I2 = 83.7%, p = 0.002). Additionally, cohort and case-control studies found that obesity probably increases the odds of migraine. No studies analysed the association between underweight and migraine. Conclusion The associations between overweight, obesity, excess weight and migraine were uncertain, but studies with better methodological quality reported increased odds. Future longitudinal studies with proper confounding control are needed to disentangle their causal relationship. Systematic review registration PROSPERO, identifier CRD42021271533.
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    The impact of the COVID-19 pandemic on HIV testing in Peru: an interrupted time series analysis from 2014 to 2022
    (BioMed Central Ltd, 2025-01-07)
    Yrene-Cubas, Robinson A.
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    Pérez-Castilla, Jesus
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    Reynaga-Cottle, Daniel E.
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    Bringas, Maria José
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    Soriano Moreno, David  
    Objectives Our objective was to evaluate the impact of COVID-19 on the proportion of past-year HIV testing in Peru. Methods Utilizing data from the National Demographic and Health Survey of Peru from 2014 to 2022, we conducted an interrupted time series analysis. The proportion of past-year HIV testing per quarter of each year was considered our unit of analysis. Statistical analysis involved segmented regression with Newey-West standard errors, dividing each year of evaluation into four quarters. Additionally, we applied an Autoregressive Integrated Moving Average (ARIMA) model. Results We included 211,359 participants aged 15 to 49 years. The proportion of past-year HIV testing in Peru showed a mean decrease of 8.33% (95%CI: -10.73% to -5.93%) after the COVID-19 lockdown (from August-2020) compared to the previous period (before March-2020). Prior to lockdown, there was a mean quarterly increase of 0.30% (95%CI: 0.21-0.40%) in testing proportion, while after the lockdown, there was a mean quarterly decrease of -0.24% (95%CI: -0.56-0.09%). HIV testing declined in 23 of the 25 regions, ranging from - 23.7% to -3.0%, except in Amazonas and Cajamarca, where increases of 5.3% and 6.8% were observed. Predictions of counterfactual values without the pandemic using the ARIMA model revealed a percentage drop of -9.20% (95%CI: -13.70 to -4.80) in observed compared to predicted values. Conclusions This study highlights the decrease in proportion of past-year HIV testing in Peru following the COVID-19 lockdown, emphasizing the urgent need for targeted interventions to address disparities and ensure equitable access to testing services.
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    Undergraduate courses of evidence-based medicine in Peruvian medical schools: Characteristics and addressed topics
    (Elsevier Ltd, 2023-01-30)
    Alarcon-Ruiz, Christoper A.
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    Soriano Moreno, David  
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    Taype-Rondán, Álvaro Renzo
    Background Medical schools are increasingly including evidence-based medicine (EBM) courses in their curricula. However, little is known about the characteristics of these courses in Peru. Therefore, the present study aimed to describe the characteristics and topics addressed by undergraduate courses on EBM in Peruvian medical schools, and to compare the content of these courses with predefined EBM competencies. Methods We conducted a cross-sectional study. We obtained the syllabi of undergraduate EBM courses from all medical schools for the latest year available. We extracted their characteristics and categorized the topics they included according to the five steps necessary to apply EBM, divided into 22 competencies. Results In 2021, Peru had 47 universities with active undergraduate medical schools, of which 9 (19.1%) had EBM courses. These courses were not mandatory in three of the universities, and were typically offered between the 2nd and 5th year of the degree program. When analysing the topics covered in the syllabi, we found that they addressed 7 to 13 of the 22 core competencies evaluated. The least addressed topics belonged to steps 4 (apply) and 5 (evaluate) of the EBM process. Conclusion We found that few Peruvian universities offer EBM courses, and that these courses have heterogeneous characteristics, with syllabi that do not include all essential topics for applying the five steps of EBM.
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    Association between self-reported evidence-based medicine competencies and prescribing of drugs without scientific evidence against mild COVID-19 among recently graduated physicians in Peru
    (Elsevier Ltd, 2023-04-01)
    Fernandez-Guzman, Daniel
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    Caira-Chuquineyra, Brenda
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    Baca-Rondan, Fiorella
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    Yucra-Sosa, Maria Cristina
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    Ccami-Bernal, Fabricio
    Objective To evaluate the association between self-rated evidence-based medicine (EBM) competencies and the prescription of drugs without scientific evidence against mild COVID-19 (present with any of the signs and symptoms of COVID-19 but who do not have shortness of breath, dyspnea, or abnormal chest imaging) among recently graduated physicians in Peru. Methods We conducted an analytical cross-sectional study where we evaluated a non-probability sample of recently graduated physicians during June and July 2021 (end of second wave of COVID-19 in Peru). Self-rated EBM competencies were assessed by four domains (formulation of a clinical question, search, analysis, and application) using a Likert scale with scores from zero to four ("Very inadequate" = 0, to "Very Adequate" = 4), it was considered as "Adequate" if the score was three or four. In addition, the variable "General competence on EBM" was rated as "Adequate" if in all domains evaluated it presented an adequate self-rating. For the outcome, drug prescription, we considered the use of ivermectin, azithromycin, other antibiotics, hydroxychloroquine, dexamethasone, and anticoagulants (drugs with no efficacy demonstrated for patients with mild COVID-19). To assess the association, we used Poisson regression models with robust variances and obtaining crude (cPR) and adjusted (aPR) prevalence ratios with their 95% confidence intervals (95%CI). Results Of a total of 239 physicians included 70.7% prescribed at least one drug without scientific evidence. A total of 51.1% reported adequate ratings in all evaluated domains of EBM. Self-rating the "Clinical Question Formulation" competency as adequate was associated with a lower frequency of prescribing medications for mild COVID-19 (aPR: 0.93; 95% CI: 0.91-0.95). While self-rating as adequate the competency of "Identify possible implications of investigations" was associated with an increase in the prescription of such drugs (aPR: 1.14; 95% CI: 1.09-1.20). Additionally, self-rating all domains as adequate were associated with less prescription (aPR: 0.93; 95% CI: 0.90-0.96). Conclusion Seven out of ten recently graduated physicians prescribed some type of medication without scientific evidence to treat patients with mild COVID-19. Having adequate self-perceived EBM competencies was associated with a lower frequency of prescribing medications without scientific evidence to manage patients with mild COVID-19.
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