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Caracterización microbiológica y molecular de la resistencia antimicrobiana de Escherichia coli uropatógenas de hospitales públicos peruanos
Author(s)
Salvatierra, Guillermo
Universidad Peruana Cayetano Heredia
Pino, Jimena
Vásquez, Nancy
Diaz, Pilar
Ministry of Health
Martínez, Isabel
Asmat, Percy
Peralta, Carlos
Huamani, Caridad
Briones, Alexander
Ruiz, Manuel
Laura, Nicomedes
Luque, Álvaro
Arapa, Leonel
Tsukayama, Pablo
Universidad Peruana Cayetano Heredia
Date Issued
16 de marzo de 2021
Type
Article
Volume
38
Issue
1
Series/Report No.
Revista Peruana de Medicina Experimental y Salud Pública
Start Page
119
End Page
23
ISSN
1726-4634
1726-4642
Abstract
We characterized the antimicrobial resistance of 70 Escherichia coli isolates obtained from patients with a urinary tract infection (UTI) from 8 public hospitals in Peru. Resistance profiles were identified using the automated MicroScan® system. A standard polymerase chain reaction was used for the detection of the bla TEM, bla CTX-M, bla SHV and bla PER genes. The 65.7% (46/70) of the isolates presented a multidrug-resistant phenotype and 55.7% (39/70) were extended-spectrum beta-lactamases producers. High levels of resistance were detected for ampicillin (77,1%), ciprofloxacin (74,3%), trimethoprim/sulfamethoxazole (62,9%), cefepime (57,1%), and cefuroxime (57,1%). The bla TEM gene was the most frequent (31,4%), followed by bla CTX-M (18,6%) and bla SHV (2,9%) genes. These results show high resistance levels to antimicrobials of clinical use in E. coli isolates from hospital UTI patients in Peru.