Newball Noriega, Edda Evnet
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Newball Noriega, Edda Evnet
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eddanewball@upeu.edu.pe
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Item type:Publicación, - Algunas métricas están bloqueadas por suconfiguración de consentimiento
Item type:Publicación, ACP-TX-I and ACP-TX-II, Two Novel Phospholipases A2 Isolated from Trans-Pecos Copperhead Agkistrodon contortrix pictigaster Venom: Biochemical and Functional Characterization(2019-11-14); ; Sérgio MarangoniThis work reports the purification and biochemical and functional characterization of ACP-TX-I and ACP-TX-II, two phospholipases A2 (PLA2) from Agkistrodon contortrix pictigaster venom. Both PLA2s were highly purified by a single chromatographic step on a C18 reverse phase HPLC column. Various peptide sequences from these two toxins showed similarity to those of other PLA2 toxins from viperid snake venoms. ACP-TX-I belongs to the catalytically inactive K49 PLA2 class, while ACP-TX-II is a D49 PLA2, and is enzymatically active. ACP-TX-I PLA2 is monomeric, which results in markedly diminished myotoxic and inflammatory activities when compared with dimeric K49 PLA2s, confirming the hypothesis that dimeric structure contributes heavily to the profound myotoxicity of the most active viperid K49 PLA2s. ACP-TX-II exhibits the main pharmacological actions reported for this protein family, including in vivo local myotoxicity, edema-forming activity, and in vitro cytotoxicity. ACP-TX-I PLA2 is cytotoxic to A549 lung carcinoma cells, indicating that cytotoxicity to these tumor cells does not require enzymatic activity.Citas (OpenAlex): 4 - Algunas métricas están bloqueadas por suconfiguración de consentimiento
Item type:Publicación, Changes in Eating Habits and Lifestyles in a Peruvian Population during Social Isolation for the COVID-19 Pandemic(2021-12-01); ; Citas (OpenAlex): 27 - Algunas métricas están bloqueadas por suconfiguración de consentimiento
Item type:Publicación, Anticarcinogenic potential of BbTX-II on large lung cell carcinoma (NCI-H460)(2020-04-01); ; Sérgio MarangoniCitas (OpenAlex): 0metric-badges.view 1 - Algunas métricas están bloqueadas por suconfiguración de consentimiento
Item type:Publicación, Factors associated with the use of oral health services in Peruvian children under the age of 12 years(2022-10-27); OBJECTIVES: To determine the prevalence and factors associated with the use of oral health services in Peruvian children under 12 years of age. MATERIAL AND METHODS: A secondary analysis of 2019 Demographic and Family Health Survey was conducted. The sample consisted of 40,751 children. The main variable was the use of dental services (attended/not attended) in the last 6 months, and the independent variables were gender, age, area of residence, wealth quintile, health insurance coverage, information received on oral health care, age, and educational level of the caregivers. Analyses of absolute and relative frequencies, differences in proportions, and multivariate analysis using generalized linear models were performed. RESULTS: The dental service utilization prevalence during the last 6 months was 31%. Correlation was found with urban area residents (PRa = 0.945; 95% CI: 0.904-0.988), the Jungle geographical domain (PRa = 0.926; 95% CI: 0.877-0.977), the highest wealth quintile (PRa = 1.323; 95% CI: 1.232-1.421), the higher education level of the caregiver (PRa = 1.375; 95% CI: 1.231-1.536), affiliation with the Public Health Insurance (PRa = 1.112; 95% CI: 1.069-1.158), and the condition of having received information on oral health care (PRa = 2.355; 95% CI: 2.263-2.245) with respect to their baseline variables. CONCLUSIONS: Several socio-demographic factors were correlated with the use of oral health services in Peruvian children under 12 years of age and the percentage of their use was low. Information on oral health care had a more significant impact on both, the population from the highest wealth quintile and the highest educational attainment.Citas (OpenAlex): 7 - Algunas métricas están bloqueadas por suconfiguración de consentimiento
Item type:Publicación, Factors Associated with the Health-Related Self-Care Capacity of Overweight and Obese People(2024-06-20); This study aimed to investigate the relationship between beliefs about obese people and health-related self-care among overweight and obese people, considering sociodemographic aspects. This study adopted a cross-sectional design. The sample consisted of 207 participants selected through a simple random sampling method. The "Beliefs About Obese Persons Scale" (BAOP) and the "Self-Care Agency Rating Scale-Revised" (ASA-R) questionnaires were applied to data collection. The results showed that 82.6% believed that obesity is a condition the individual cannot control, and 74.4% expressed inadequate self-care regarding their health. A multivariate analysis found that belonging to the adult age group increases the probability of presenting adequate health-related self-care by 4.7 times (95% CI = 1.892-11.790) compared to older adults. The belief that obesity is an uncontrollable condition increases the probability of inadequate self-care by 6.3 times (95% CI = 2.360-16.924), in contrast to the perception that it is a controllable condition. Moreover, overweight people are 0.139 times (95% CI = 0.044-0.443) less likely to have adequate self-care compared to people with obesity. In conclusion, being an adult and having the belief that obesity is a condition that can be controlled is associated with adequate health-related self-care, while being overweight is associated with inadequate health care.Citas (OpenAlex): 1 - Algunas métricas están bloqueadas por suconfiguración de consentimiento
Item type:Publicación, Factors associated with quality of life for people in a rural area of Peru: importance of family health and socioeconomic aspects(2025-10-20); INTRODUCTION: Considering socioeconomic aspects, this study aimed to analyze the relationship between quality of life and family health in residents of a rural area of Peru. METHODS: In a cross-sectional design study, the sample comprised 288 residents chosen through simple random probabilistic sampling. It included male and female Peruvian residents aged 18 years or more who lived with their families and agreed to participate in the study. The SALUFAM (family health) scale and the Quality of Life Index are used for data collection. RESULTS: The results revealed that residents with basic education (adjusted odds ratio (aOR): 2.44, 95%CI: 1.33-4.49, p=0.004) who did not have a job (aOR: 1.66, 95%CI: 1.23-2.23, p=0.001) and who received an income less than the minimum wage (aOR: 1.45, 95%CI: 1.03-2.03, p=0.03) presented a greater probability of perceiving inadequate quality of life. Furthermore, residents with more vulnerable family health (aOR: 1.79, 95%CI: 1.34-2.38, p=0.000) were more likely to perceive an inadequate of their quality of life than those in families with less vulnerability. CONCLUSION: Socioeconomic factors and vulnerability in family health are significantly associated with a worse quality of life in these rural communities.Citas (OpenAlex): 0 - Algunas métricas están bloqueadas por suconfiguración de consentimiento
Item type:Publicación, Problematic use of the internet as a predictor of oral health-related quality of life: the mediating role of lifestyles in Peruvian schoolchildren(2024-08-10); ; BACKGROUND: The pervasiveness of the Internet in everyday life, especially among young people, has raised concerns about its effects on mental health, education, and, recently, oral health. Previous research has suggested a complex relationship between Problematic Internet Use (PIU), lifestyles, and oral health-related quality of life, highlighting the need to examine these interactions further. This study seeks to explore the PIU as a predictor of oral health-related quality of life and examine the mediating role of lifestyles between both in a sample of Peruvian schoolchildren. METHODS: A cross-sectional study was carried out with 293 Peruvian students aged 12 to 17 years (M = 14.42, SD = 1.5), using structural equations to analyze the relationship between PIU, lifestyles, and quality of life related to oral health. The data collection procedure was through a face-to-face survey. Validated instruments measured PIU, lifestyles, and oral health-related quality of life. The study's theoretical model was analyzed through structural equation modeling with the MLR estimator. The fit assessment was performed using the comparative fit index (CFI), root mean square error of approximation (RMSEA), and standardized root mean square residual (SRMR). RESULTS: They indicated significant correlations between PIU, lifestyles, and oral health-related quality of life. A negative influence of PIU on lifestyles (β = -0.30, p < .001) and on oral health-related quality of life (β = -0.35, p < .001) was observed, as well as a positive relationship between PIU and oral health-related quality of life (β = 0.29, p < .001). The mediation of lifestyles was statistically significant, suggesting that they mediate the relationship between PIU and oral health-related quality of life. CONCLUSIONS: The study confirms that PIU can negatively affect adolescents' oral health-related quality of life, mediated by unhealthy lifestyles. It underlines the importance of promoting balanced Internet use and healthy lifestyles among young people to improve their oral well-being.Citas (OpenAlex): 1metric-badges.view 1 - Algunas métricas están bloqueadas por suconfiguración de consentimiento
Item type:Publicación, Food insecurity associated with self-reported mental health outcomes in Peruvian households during the COVID-19 pandemic(2022-11-04); ; ; César Augusto GálvezBackground The global pandemic of COVID-19 and the social distancing efforts implemented worldwide to limit its spread have disrupted the economy, increased food insecurity, and mental health problems. Objectives The aim of this study was to determine the association between food insecurity and mental health outcomes (stress, depression, and anxiety) in Peruvian households during the COVID-19 pandemic. Materials and methods A cross-sectional investigation was conducted with 525 participants of both sexes (68% women), over 18 years of age and from the three geographic regions of Peru: Coast (54.9%), Highlands (28.4%), and Jungle (16.8%). The data were collected during the year 2021, between July 6 and September 22 through a self-administered online survey designed to assess socio-demographic, socioeconomic, food insecurity, and mental health outcomes (depression, anxiety, and stress). Results The majority of households (71.4%) experienced some degree of food insecurity. Mild food insecurity was the most frequent, affecting 49.1%, followed by moderate 15.4%, and severe 6.9%. Regarding mental health outcomes, 24.8% manifested depression, 26.7% anxiety, and 15.3% stress. With respect to the association between the level of food insecurity and anxiety, this was highly significant ( p &lt; 0.01). Households with mild, moderate and severe food insecurity are 2.04, 4.5, and 10.44 times, respectively, more likely to have moderate-severe anxiety. On the other hand, the mild food insecurity was not associated with moderate-severe depression. In contrast, households with moderate and severe food insecurity are 2.8 and 5.7 times, respectively, more likely to have moderate-severe depression. Finally, households with moderate food insecurity are 5.9 times more likely to have moderate-severe stress, and households with severe food insecurity are 8.5 times more likely to have moderate-severe stress, both having a highly significant association ( p &lt; 0.01). Conclusion In conclusion, during the second wave of the COVID-19 pandemic in Peru, household food insecurity was independently associated with worse mental health outcomes. Monitoring of both food insecurity and mental health will be important as the COVID-19 pandemic continues.Citas (OpenAlex): 8metric-badges.view 1 - Algunas métricas están bloqueadas por suconfiguración de consentimiento
Item type:Publicación, Dietary practices and nutritional status of children served in a social program for surrogate mothers in Colombia(2023-02-06); ; ; Jacksaint SaintilaBACKGROUND: Dietary practices are acquired in the family context and in turn can affect the health of family members, especially the nutritional status of children. The objective of this study was to determine the relationship between nutritional status and feeding practices in children from foster families served by the SOS Children's Villages program in Cartagena, Colombia. METHODS: The study had a cross-sectional design. Through a non-probabilistic purposive sampling, 139 children from 0 to 5 years of age from the SOS Children's Villages Cartagena program were involved. The sociodemographic background of the participants was recorded and the nutritional status of the children was evaluated through anthropometric and biochemical measurements. Dietary practices were measured by means of a standardized questionnaire. Analyses were performed with Poisson regression models with robust variance. These regression models provided prevalence ratios (PR) with their respective 95% confidence intervals (95%CI). RESULTS: Among dietary practices, it was observed that most families eat together at home (63.3%), watch television when they eat (55.4%), and have dietary norms (80.6%). Consumption of plant foods was predominantly high, especially vegetables (86.3%), fruits (92.1%), cereals (84.9%), root vegetables, and bananas (93.5%). Consumption < 4 times/week of soft drinks and industrialized juices increases 14.3 times the probability of low weight-for-height in the study population compared to the group that does not consume them. On the other hand, watching television while eating (PR: 2.82, 95%CI 1.32-4.69) and consumption of sweet snacks (PR: 2.24, 95%CI 1.03-4.87) increased the probability of low height-for-age; while having eaten norms at home decreased the probability of low height-for-age in the study population by 50%. CONCLUSION: It is necessary to develop and implement interventions such as preventive measures and early diagnosis of inappropriate feeding behaviors to ensure adequate nutritional status among children under 5 years of age.Citas (OpenAlex): 6