Newball Noriega, Edda Evnet
Preferred name
Newball Noriega, Edda Evnet
Main Affiliation
Email
eddanewball@upeu.edu.pe
ORCID
Scopus Author ID
15 resultados
Mostrando 1 - 10 de 15
- Some of the metrics are blocked by yourconsent settings
Item type:Publicación, A Novel Fast and Efficient Approach to Purify the Thrombin-like Enzyme from Two &lt;i&gt;Bothrops&lt;/i&gt;-genus Snake Venoms(2021-01-01) ;Maurício Aurelio Gomes Heleno; ; ;Rui Seabra FerreiraBenedito BarravieraSnake venoms are important sources of complex substances with a variety of pharmacological activities. Among them serine proteinases (SVSPs) have important effects on the hemostatic system influencing the hemodynamic of human or animal blood. <i>Bothrops</i> genus-snake venoms are rich in the thrombin-like enzyme, a type of SVSPs, with great interest to produce medicine. Therefore, the aim of this work was to describe a rapid, only two-step chromatographic-procedure developed to perform a faster purification of SVSPs from <i>Bothrops alternatus</i> and <i>Bothrops moojeni</i> venoms. As a result, two groups of serine proteinases respectively BaIII-4 - 8 and BmIII-2 - 5, were isolated and their molecular masses estimated by mass spectrometry and SDS-PAGE under denaturing conditions. The SVTLEs isolated from <i>B. alternatus</i> (BaIII-3 - 8) and <i>B. moojeni</i> (BmIII-2 - 5) fractions displayed apparent molecular mass around 30-40 kDa which closely relates to SVTLEs from other <i>Bothrops</i> species, as well their amino acid partial sequence triptych ions. Analysis of the alignment of the amino acid residue sequences of the N-terminal of the isolated proteins revealed a high level of identity with other SVTLEs. These enzymes coagulated plasma and showed fibrinogenolytic activity in blood. These SVTLEs isolated can be considered α-fibrinogenase mainly due to the fact that they hydrolyze the Aα chain fibrinogen. <i>B. moojeni</i> SVTLE showed greater activity than those from <i>B. alternatus</i> isolated. This new purification alternative approach developed was faster and more economical than the traditional process currently used. Faster purification and improved extraction yield can provide new insights into these enzymes including the use as a candidate molecule in the production of new drugs. - Some of the metrics are blocked by yourconsent settings
Item type:Publicación, Percepción del ambiente educacional en internos de medicina de Hospitales públicos y Clínicas privadas del Perú: un análisis comparativo(2022-12-09) ;Daniel Quispe Morales; ; Melina Zumacc Centeno HuacreObjetivos: 
 Determinar y comparar la percepción del ambiente educacional de los internos de medicina de hospitales públicos y clínicas privadas del Perú
 Métodos: 
 Se llevó a cabo un estudio Observacional de corte transversal, mediante el cuestionario PHEEM el cual fue respondido por 101 estudiantes que realizaban su internado en clínicas y hospitales del Perú; el muestreo fue no probabilístico y por conveniencia debido a la facilidad de acceso a dichas sedes. Los datos fueron analizados en el programa SPSS versión 23, se realizó un análisis descriptivo y otro comparativo a través de la prueba de T student tanto en los puntajes globales cómo en cada una de las dimensiones del cuestionario
 Resultados: 
 La media global de las puntuaciones del ambiente educacional medico fue de 83.16 (DS 25.4) indicando un ambiente más positivo que negativo. Al comparar las medias entre los internos de los hospitales y los de las clínicas, el ambiente fue mejor percibido por los estudiantes que realizaban su internado en las clínicas privadas tanto en puntaje global, como en todas las dimensiones p valor <0.05 indicando diferencia estadísticamente significativa. La dimensión más preocupante fue la enseñanza donde se observó la mayor diferencia entre estos dos sectores.
 Conclusiones:
 Existe una percepción negativa en los internos de hospitales comparados a los internos de clínicas. Se deberían realizar estrategias de intervención de mejoría en los internos de hospitales para cada una de las dimensiones del ambiente educacional, en especial en la enseñanza. - Some of the metrics are blocked by yourconsent settings
Item type:Publicación, ACP-TX-I and ACP-TX-II, Two Novel Phospholipases A2 Isolated from Trans-Pecos Copperhead Agkistrodon contortrix pictigaster Venom: Biochemical and Functional Characterization(2019-11-14); ;Luciana Maria de Hollanda ;Mauricio Gomes-Heleno; Sérgio MarangoniThis work reports the purification and biochemical and functional characterization of ACP-TX-I and ACP-TX-II, two phospholipases A2 (PLA2) from Agkistrodon contortrix pictigaster venom. Both PLA2s were highly purified by a single chromatographic step on a C18 reverse phase HPLC column. Various peptide sequences from these two toxins showed similarity to those of other PLA2 toxins from viperid snake venoms. ACP-TX-I belongs to the catalytically inactive K49 PLA2 class, while ACP-TX-II is a D49 PLA2, and is enzymatically active. ACP-TX-I PLA2 is monomeric, which results in markedly diminished myotoxic and inflammatory activities when compared with dimeric K49 PLA2s, confirming the hypothesis that dimeric structure contributes heavily to the profound myotoxicity of the most active viperid K49 PLA2s. ACP-TX-II exhibits the main pharmacological actions reported for this protein family, including in vivo local myotoxicity, edema-forming activity, and in vitro cytotoxicity. ACP-TX-I PLA2 is cytotoxic to A549 lung carcinoma cells, indicating that cytotoxicity to these tumor cells does not require enzymatic activity. - Some of the metrics are blocked by yourconsent settings
Item type:Publicación, Factors Associated with the Health-Related Self-Care Capacity of Overweight and Obese People(2024-06-20) ;Liz K. Tenorio-Guerrero ;Romara Puente-Alejos ;Janett V. Chávez Sosa; This study aimed to investigate the relationship between beliefs about obese people and health-related self-care among overweight and obese people, considering sociodemographic aspects. This study adopted a cross-sectional design. The sample consisted of 207 participants selected through a simple random sampling method. The "Beliefs About Obese Persons Scale" (BAOP) and the "Self-Care Agency Rating Scale-Revised" (ASA-R) questionnaires were applied to data collection. The results showed that 82.6% believed that obesity is a condition the individual cannot control, and 74.4% expressed inadequate self-care regarding their health. A multivariate analysis found that belonging to the adult age group increases the probability of presenting adequate health-related self-care by 4.7 times (95% CI = 1.892-11.790) compared to older adults. The belief that obesity is an uncontrollable condition increases the probability of inadequate self-care by 6.3 times (95% CI = 2.360-16.924), in contrast to the perception that it is a controllable condition. Moreover, overweight people are 0.139 times (95% CI = 0.044-0.443) less likely to have adequate self-care compared to people with obesity. In conclusion, being an adult and having the belief that obesity is a condition that can be controlled is associated with adequate health-related self-care, while being overweight is associated with inadequate health care. - Some of the metrics are blocked by yourconsent settings
Item type:Publicación, An unusual phospholipase A2 from Porthidium hyoprora venom snake: Purification, structural and pharmacological properties(2020-04-01); ; Sérgio Marangoni - Some of the metrics are blocked by yourconsent settings
Item type:Publicación, Factors associated with quality of life for people in a rural area of Peru: importance of family health and socioeconomic aspects(2025-10-20) ;Larico Ayma ;Juan Pedro Tacoronte Sosa; INTRODUCTION: Considering socioeconomic aspects, this study aimed to analyze the relationship between quality of life and family health in residents of a rural area of Peru. METHODS: In a cross-sectional design study, the sample comprised 288 residents chosen through simple random probabilistic sampling. It included male and female Peruvian residents aged 18 years or more who lived with their families and agreed to participate in the study. The SALUFAM (family health) scale and the Quality of Life Index are used for data collection. RESULTS: The results revealed that residents with basic education (adjusted odds ratio (aOR): 2.44, 95%CI: 1.33-4.49, p=0.004) who did not have a job (aOR: 1.66, 95%CI: 1.23-2.23, p=0.001) and who received an income less than the minimum wage (aOR: 1.45, 95%CI: 1.03-2.03, p=0.03) presented a greater probability of perceiving inadequate quality of life. Furthermore, residents with more vulnerable family health (aOR: 1.79, 95%CI: 1.34-2.38, p=0.000) were more likely to perceive an inadequate of their quality of life than those in families with less vulnerability. CONCLUSION: Socioeconomic factors and vulnerability in family health are significantly associated with a worse quality of life in these rural communities. - Some of the metrics are blocked by yourconsent settings
Item type:Publicación, Dietary practices and nutritional status of children served in a social program for surrogate mothers in Colombia(2023-02-06) ;Patricia Acosta; ; ;Wilter C. Morales-GarcíaJacksaint SaintilaBACKGROUND: Dietary practices are acquired in the family context and in turn can affect the health of family members, especially the nutritional status of children. The objective of this study was to determine the relationship between nutritional status and feeding practices in children from foster families served by the SOS Children's Villages program in Cartagena, Colombia. METHODS: The study had a cross-sectional design. Through a non-probabilistic purposive sampling, 139 children from 0 to 5 years of age from the SOS Children's Villages Cartagena program were involved. The sociodemographic background of the participants was recorded and the nutritional status of the children was evaluated through anthropometric and biochemical measurements. Dietary practices were measured by means of a standardized questionnaire. Analyses were performed with Poisson regression models with robust variance. These regression models provided prevalence ratios (PR) with their respective 95% confidence intervals (95%CI). RESULTS: Among dietary practices, it was observed that most families eat together at home (63.3%), watch television when they eat (55.4%), and have dietary norms (80.6%). Consumption of plant foods was predominantly high, especially vegetables (86.3%), fruits (92.1%), cereals (84.9%), root vegetables, and bananas (93.5%). Consumption < 4 times/week of soft drinks and industrialized juices increases 14.3 times the probability of low weight-for-height in the study population compared to the group that does not consume them. On the other hand, watching television while eating (PR: 2.82, 95%CI 1.32-4.69) and consumption of sweet snacks (PR: 2.24, 95%CI 1.03-4.87) increased the probability of low height-for-age; while having eaten norms at home decreased the probability of low height-for-age in the study population by 50%. CONCLUSION: It is necessary to develop and implement interventions such as preventive measures and early diagnosis of inappropriate feeding behaviors to ensure adequate nutritional status among children under 5 years of age. - Some of the metrics are blocked by yourconsent settings
Item type:Publicación, Analysis of adherence to a healthy lifestyle among vegetarian and non-vegetarian Peruvian university students: A cross-sectional survey(2024-02-23); ; ; ; Felipe L Ignacio-CconchoyBACKGROUND: Evidence shows that a healthy lifestyle can promote physical and mental well-being in the general population. However, there are few studies that assess the adherence to a healthy lifestyle in vegetarian and non-vegetarian university students. The purpose of this study was to evaluate the differences in adherence to a healthy lifestyle between vegetarian and non-vegetarian university students in Peru. METHODS: A cross-sectional study was carried out considering data from 6,846 students selected by non-probabilistic convenience sampling. The Diet and Healthy Lifestyle Scale (DEVS), the Peruvian validation of the Vegetarian Lifestyle Index (VLI), was used. In addition, sociodemographic and anthropometric data such as weight and height were collected. Body mass index (BMI) was also calculated. RESULTS: Semi-vegetarian and vegetarian students had a high healthy lifestyle score compared to non-vegetarians. In addition, vegetarian diets showed a significantly higher proportion among students with a lower BMI (normal and underweight). Students with excess body weight (overweight and obesity) were less likely to report healthy lifestyle. In the overall population analyzed, it was observed that the levels of health and lifestyle behaviors, such as daily exercise and sunlight exposure, were mostly moderate and low. Additionally, sweets intake was high, while healthy food consumption such as fruits, vegetables, legumes, and whole grains was low. CONCLUSION: The current findings show that although vegetarians had better adherence to a healthy lifestyle, interventions in the university setting are needed to improve healthy lifestyle in university students. - Some of the metrics are blocked by yourconsent settings
Item type:Publicación, Association of low knowledge about cardiovascular disease and lack of lifestyle changes after the COVID-19 pandemic with higher cardiovascular risk in Peruvian residents(2025-07-01) ;Arfaxad M. Barreto-Vega ;Brandon M. Gaytan Caycho; Background: Cardiovascular diseases (CVD) are the leading cause of mortality and disability-adjusted life years (DALYs) worldwide. This study aimed to evaluate the association between low knowledge about cardiovascular disease, the absence of lifestyle changes after the COVID-19 pandemic, and cardiovascular risk among Peruvian resident. Design and methods: Analytical and cross-sectional study. The sample consisted of 371 participants. The Knowledge about Cardiovascular Diseases questionnaire, the Pocket Guide for estimating and managing cardiovascular risk, and the Changes in lifestyle during the quarantine period scale were used. Moreover, to establish independent associations of the variables of interest, the PRc and PRa of each factor were determined through Poisson regression models with robust variance. Results: About 60.4% of participants had changes in lifestyle after the pandemic, 69.8% had a low level of knowledge about the risk of cardiovascular disease, and 18.6% had a moderate-high cardiovascular risk. The bivariate analysis found that the population that did not change their lifestyles after the pandemic had a significantly higher cardiovascular risk than those who did make changes. Likewise, low knowledge about cardiovascular risk and disease was associated with a higher level of cardiovascular risk. The multivariate model showed that participants who did not have changes in lifestyle after the pandemic were 3.34 times more likely to have a higher level of cardiovascular risk (95% CI 2.09-5.34). Conclusions: Residents who did not have changes in lifestyle after the COVID-19 pandemic and expressed low knowledge about cardiovascular disease have a higher cardiovascular risk. - Some of the metrics are blocked by yourconsent settings
Item type:Publicación, Food insecurity associated with self-reported mental health outcomes in Peruvian households during the COVID-19 pandemic(2022-11-04) ;Maria M. Anampa-Canales; ; ;Wilter C. Morales-GarcíaCésar Augusto GálvezBackground The global pandemic of COVID-19 and the social distancing efforts implemented worldwide to limit its spread have disrupted the economy, increased food insecurity, and mental health problems. Objectives The aim of this study was to determine the association between food insecurity and mental health outcomes (stress, depression, and anxiety) in Peruvian households during the COVID-19 pandemic. Materials and methods A cross-sectional investigation was conducted with 525 participants of both sexes (68% women), over 18 years of age and from the three geographic regions of Peru: Coast (54.9%), Highlands (28.4%), and Jungle (16.8%). The data were collected during the year 2021, between July 6 and September 22 through a self-administered online survey designed to assess socio-demographic, socioeconomic, food insecurity, and mental health outcomes (depression, anxiety, and stress). Results The majority of households (71.4%) experienced some degree of food insecurity. Mild food insecurity was the most frequent, affecting 49.1%, followed by moderate 15.4%, and severe 6.9%. Regarding mental health outcomes, 24.8% manifested depression, 26.7% anxiety, and 15.3% stress. With respect to the association between the level of food insecurity and anxiety, this was highly significant ( p &lt; 0.01). Households with mild, moderate and severe food insecurity are 2.04, 4.5, and 10.44 times, respectively, more likely to have moderate-severe anxiety. On the other hand, the mild food insecurity was not associated with moderate-severe depression. In contrast, households with moderate and severe food insecurity are 2.8 and 5.7 times, respectively, more likely to have moderate-severe depression. Finally, households with moderate food insecurity are 5.9 times more likely to have moderate-severe stress, and households with severe food insecurity are 8.5 times more likely to have moderate-severe stress, both having a highly significant association ( p &lt; 0.01). Conclusion In conclusion, during the second wave of the COVID-19 pandemic in Peru, household food insecurity was independently associated with worse mental health outcomes. Monitoring of both food insecurity and mental health will be important as the COVID-19 pandemic continues.
